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个人信息Personal Information
副教授
硕士生导师
性别：女
毕业院校：新加坡国立大学
学位：博士
所在单位：生物工程学院
学科：生物工程. 生物化学与分子生物学. 生物化工
办公地点：生物工程学院511
电子邮箱：dushubo@dlut.edu.cn
个人简介Personal Profile
都书博，副教授、硕士生导师。2019年在新加坡国立大学获得理学博士，之后在新加坡国立大学化学系从事博士后研究工作，2022年受聘于大连理工大学。主要研究生物分子靶向控释，紧紧围绕新型疫苗和抗体药物开发、癌细胞检测及治疗的关键科学问题，对抗体药物的细胞内递送及对肿瘤的抑制和探索肿瘤细胞蛋白质组学等开展了研究工作，取得一系列创新性研究成果。相关成果共发表SCI收录论文20篇，分别发表在ACS Central Science, Journal of the American Chemical Society, Angewandte Chemie International Edition等国际著名学术期刊上。
欢迎具有生物工程、生物化工、化学、生物等背景的同学报考。
代表性论文
Zhang, B., Brahma, K. R., Zhu, L., Feng, J., Hu, S., Qian, L., Du, S.*; Yao, S. Q.*, Ge, J.*, Insulin-like Growth Factor 2 (IGF2)-Fused Lysosomal Targeting Chimeras for Degradation of Extracellular and Membrane Proteins. J. Am. Chem. Soc. 2023, 145, 24272-24283.
Qian, L.*; Lin, X.; Gao, X.; Khan, R. U.; Liao, J.-Y.; Du, S.*; Ge, J.; Zeng, S.; Yao, S. Q.*, The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics. Chemical Reviews 2023, 123, 7782-7853.
Du, W.#; Du, S.#; Dong, X.#; Bai, H.; Jiang, J.; Hao, S.; Yang, F.; Xiao, Q.; Zhang, B.; Ge, J.; Gao, L.; Li, L.*; Yao, S. Q.*; Huang, W.*, Biodegradable silica nanocapsules enable efficient nuclear-targeted delivery of native proteins for cancer therapy. Biomaterials 2023, 294, 122000. (#共同一作)
Ge, J.; Du, S.*; Yao, S. Q.*, Bifunctional Lipid-Derived Affinity-Based Probes (AfBPs) for Analysis of Lipid–Protein Interactome. Accounts of Chemical Research 2022, 55 (24), 3663-3674.
Xie, Y.#; Du, S.#; Liu, Z.; Liu, M.; Xu, Z.; Wang, X.; Kee, J. X.; Yi, F.*; Sun, H.*; Yao, S. Q.*, Chemical Biology Tools for Protein Lysine Acylation. Angew. Chem. Int. Ed. 2022.04, 61 (21), e202200303. (#共同一作)
Du, S.; Liew, S. S.; Zhang, C-w.; Du, W.; Lang, W.; Yao, C. Y.; Li, L.; Ge, J.*; Yao, S. Q.*, Cell-Permeant Bioadaptors for Cytosolic Delivery of Native Antibodies: A “Mix-and-Go” Approach. ACS Cent. Sci. 2020.12, 6 (12), 2362–2376.
Qu, Y.; Zhan, Q.; Du, S.*; Ding, Y.; Fang, B.; Du, W.; Wu, Q.*; Yu, H.; Li, L.*; Huang, W., Catalysis-based specific detection and inhibition of tyrosinase and their application. J. Pharm. Anal. 2020.10, 10 (5), 414-425.
Du, S.; Liew, S. S.; Li, L.; Yao, S. Q.*, Bypassing endocytosis: direct cytosolic delivery of proteins. J. Am. Chem. Soc. 2018.11, 140 (47), 15986-15996.
Du, S.; Wang, D.; Lee, J.-S.; Peng, B.; Ge, J.*; Yao, S. Q.*, Cell type-selective imaging and profiling of newly synthesized proteomes by using puromycin analogues. Chem. Commun. 2017.08, 53 (60), 8443-8446.