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发表时间：2014-01-01

发表刊物：高校化学工程学报

所属单位：化工学院

期号：3

页面范围：592-599

ISSN号：1003-9015

摘要：Conductive HA (Hyaluronic Acid)-doped PEDOT (Poly 3,4-ethylenedioxythiophene) particles were synthesized through chemical polymerization and an orthogonal experiment was designed to improve the conductivity of these PEDOT particles. The results show that when the experiment is conducted under conditions of HA 0.05 g, ammonium persulfate (APS ) 0.015 mol and reaction time of 24 hours, the optimized conductivity measured by four-point probe can reach to 0.36 S·cm-1. A conductive biodegradable PEDOT/PLLA composite membrane was prepared by incorporating HA-doped PEDOT particles to biodegradable PLLA (Poly L, lactic acid). FT-IR and EDX results confirm the presence of HA on the PEDOT particles, and the surface morphology of PEDOT particles and the PEDOT/PLLA composite membrane were observed with SEM. PC12 cells were cultured on the 30%PEDOT/PLLA membrane modified by LN (laminin protein) and the cells demonstrate normal morphology, high adhesion and longer cell synaptic attachment on the membrane. Compared with the control group, PEDOT/PLLA membrane can effectively increase cell viability by (116.6±3.2)%after 72 hour. The results show that the conductive biodegradable PEDOT/PLLA membrane is useful in nervous tissue engineering for preparing conductive biodegradable scaffolds.

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