关水，大连理工大学化工学院化学工程系副教授，硕士生导师。大连理工大学精准转化医学控制工程研究中心副主任。辽宁省神经科学学会理事，中国神经科学学会、中国细胞生物学会、中国药理学会会员。Acta Biomater、Carbohyd Polym、ACS Appl Mater Inter、Rev Chem Eng、Int J Biol Macromol、Oxid Med Cell Longev等知名SCI期刊审稿人。2011-2012英国牛津大学（University of Oxford）工程科学系生物医学工程研究所访问学者。研究方向包括神经系统疾病药物筛选及毒性评价、干细胞与组织工程、精准转化医学智能材料、微生态大脑保护与修复等，主持及参与科技部国家重点研发计划、国家自然科学基金、教育部博士点新教师基金、国家重点实验室开放研究基金、教育部长江学者讲座教授基金以及大连市科技计划等多项科研工作。在Carbohyd Polym、J Mater Chem B、Mat Sci Eng C-Mater、Int J Biol Macromol、Biomater Sci、Food Chem Toxicol、Eur J Pharmacol、Toxicol In Vitro等国际高水平SCI/EI期刊发表论文80余篇，参与撰写Elsevier公司出版的一套关于生物工程和生物技术领域英文工具书《Comprehensive Biotechnology（第二版）》（2011）。申请/授权国家发明专利25项。

代表性论文及专利（# 共同第一作者；* 通讯作者）:

1. Shuping Wang, Shui Guan*, Changkai Sun, Hailong Liu, Tianqing Liu, Xuehu Ma. Electrical stimulation enhances the neuronal differentiation of neural stem cells in three-dimensional conductive scaffolds through the voltage-gated calcium ion channel. Brain Res. 2023 Jan 1;1798: 148163. (SCI, IF=3.61, JCR Q3)

2. Yujiao Yan#, Shui Guan#*, Shuping Wang, Jianqiang Xu, Changkai Sun*. Synthesis and characterization of protocatechuic acid grafted carboxymethyl chitosan with oxidized sodium alginate hydrogel through the Schiff's base reaction. Int J Biol Macromol. 2022 Oct 10; S0141-8130(22)02280-2. (SCI, IF=8.025, Top, JCR Q1)

3. Shui Guan*, Yangbin Wang, Feng Xie, Shuping Wang, Weping Xu, Jianqiang Xu*, Changkai Sun*. Carboxymethyl chitosan and gelatin hydrogel scaffolds incorporated with conductive PEDOT nanoparticles for improved neural stem cell proliferation and neuronal differentiation. Molecules, 2022, 27, 8326. (SCI, IF=4.927, JCR Q2)

4. Rui Yang#, Shibo Sun#, Yining Guo, Yao Meng, Haowen Liu, Meiyun Shi, Shui Guan*, Jianqiang Xu*. Anti-Inflammatory Effect of Dimethyl Fumarate Associates with the Inhibition of Thioredoxin Reductase 1 in RAW 264.7 Cells. Molecules, 2022, 28, 107. (SCI, IF=4.927, JCR Q2)

5. Xie F., Wang S.P., Sun C.K.*, Guan S*. Preparation of conductive hydrogel and its effect on the proliferation of neural stem cells. 10th Annual International Conference on Material Science and Engineering (ICMSE 2022), Sep 2022. (EI)

6. Li J., Xu C., Sun C.K.*, Guan S*. Edaravone-Loaded Sodium Alginate/Carboxymethyl Chitosan Composite Flim for the Healing of Chronic Wound. 10th Annual International Conference on Material Science and Engineering (ICMSE 2022), Sep 2022. (EI)

7. Chao Xu, Shui Guan*, Jianqiang Xu, Weitao Gong, Tianqing Liu, Xuehu Ma, Changkai Sun. Preparation, Characterization and Antioxidant Activity of Protocatechuic Acid Grafted Carboxymethyl Chitosan and Its Hydrogel. Carbohydrate Polymers, 2021, 252: 117210. (SCI/EI, IF=10.723, Top, JCR Q1) 被引频次：46

8. Shuping Wang, Shui Guan*, Wenfang Li, Dan Ge, Jianqiang Xu, Changkai Sun, Tianqing Liu, Xuehu Ma. 3D culture of neural stem cells within conductive PEDOT layer-assembled chitosan/gelatin scaffolds for neural tissue engineering. Materials Science & Engineering C-Materials for Biological Applications, 2018, 93: 890-901. (SCI/EI, IF=8.457, JCR Q1) 被引频次：65

9. Chao Xu, Shui Guan*, Bo Wang, Shuping Wang, Yuxin Wang, Changkai Sun, Tianqing Liu, Xuehu Ma. Synthesis of protocatechuic acid grafted chitosan copolymer: structure characterization and in vitro neuroprotective potential. International Journal of Biological Macromolecules, 2018, 109: 1-11. (SCI, IF=8.025, Top, JCR Q1) 被引频次：23

10. Chao Xu, Shui Guan*, Shuping Wang, Weitao Gong, Tianqing Liu, Xuehu Ma, Changkai Sun. Biodegradable and electroconductive poly(3,4-ethylenedioxythiophene)/ carboxymethyl chitosan hydrogels for neural tissue engineering. Materials Science & Engineering C-Materials for Biological Applications, 2017, 84: 32-43. (SCI/EI, IF=8.457, JCR Q1) 被引频次：60

11. Shuping Wang, Shui Guan*, Jianqiang Xu, Wenfang Li, Dan Ge, Changkai Sun, Tianqing Liu, Xuehu Ma. Neural stem cells proliferation and differentiation in the conductive PEDOT-HA/Cs/Gel scaffold for neural tissue engineering. Biomaterials Science, 2017, 5: 2024-2034. (SCI/EI, IF=7.59, JCR Q1, Cover) 被引频次：61

12. Shuping Wang^#, Changkai Sun^#, Shui Guan*, Wenfang Li, Jianqiang Xu, Dan Ge, Meiling Zhuang, Tianqing Liu, Xuehu Ma. Chitosan/gelatin porous scaffolds assembled with conductive poly (3,4-ethylenedioxythiophene) nanoparticles for neural tissue engineering. Journal of Materials Chemistry B, 2017, 5: 4774-4788. (SCI/EI, IF=7.571, Top, JCR Q1) 被引频次：88

13. Shuping Wang, Shui Guan*, Jing Wang, Hailong Liu, Tianqing Liu, Xuehu Ma, Zhanfeng Cui. Fabrication and characterization of conductive poly(3,4-ethylenedioxythiophene) doped with hyaluronic acid/poly(L-lactic acid) composite film for biomedical application, Journal of Bioscience and Bioengineering, 2017, 123: 116-125. (SCI/EI, IF=3.185, JCR Q3) 被引频次：41

14. Shuping Wang, Shui Guan*, Zhibo Zhu, Wenfang Li, Tianqing Liu, Xuehu Ma. Hyaluronic acid doped-poly(3,4-ethylenedioxythiophene)/chitosan/gelatin (PEDOT-HA/Cs/Gel) porous conductive scaffold for nerve regeneration, Materials Science & Engineering C-Materials for Biological Applications, 2017, 71: 308-316. (SCI/EI, IF=8.457, JCR Q1) 被引频次：69

15. Shui Guan*, Jianqiang Xu, Yifu Guo, Dan Ge, Tianqing Liu, Xuehu Ma, Zhanfeng Cui. Pyrroloquinoline quinone against glutamate-induced neurotoxicity in cultured neural stem and progenitor cells. International Journal of Developmental Neuroscience, 2015, 42, 37-45. (SCI, IF=2.54, JCR Q3) 被引频次：11

16. Shui Guan*, Xiuli Zhang, Xiaomin Lin, et al. Chitosan/gelatin porous scaffolds containing hyaluronic acid and heparan sulfate for neural tissue engineering. Journal of Biomaterials Science, Polymer Edition, 2013, 24(8): 999-1014. (SCI/EI, IF=3.682, JCR Q2) 被引频次：51

17. Shui Guan*. Development of in Vitro Neural Models for Drug Discovery and Toxicity Screening. In: Murray Moo-Young (Ed.), Comprehensive Biotechnology, 2e, 2011. Publisher: Elsevier, Amsterdam, Netherlands, pp. 565-572. (SCI) 

18. Shui Guan*, Xiuli Zhang, Dan Ge, Tian-Qing Liu, Xue-Hu Ma, Zhan-Feng Cui. Protocatechuic acid promotes the neuronal differentiation and facilitates survival of phenotypes differentiated from cultured neural stem and progenitor cells. European Journal of Pharmacology, 2011, 670 (2-3): 471-478. (SCI, IF=5.195, JCR Q2) 被引频次：14

19. Xiu-li Zhang, Gui-Fang Shi, Xiu-zhen Liu, Li-jia An, Shui Guan*. Anti-aging effects of protocatechuic acid from Alpinia on spleen and liver antioxidative system of senescent mice. Cell Biochemistry and Function, 2011, 29 (4): 342-347. (SCI, IF=3.963, JCR Q3) 被引频次：44

20.  Shui Guan*, Dan Ge, Tianqing Liu, Xue-hu Ma, Zhan-fang Cui. Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells. Toxicology in Vitro, 2009, 23(2), 201-208. (SCI, IF=3.685, JCR Q2) 被引频次：72

21. Shui Guan, Jiang B, Bao YM, An LJ. Protocatechuic acid suppresses MPP+-induced mitochondrial dysfunction and apoptotic cell death in PC12 cells. Food and Chemical Toxicology, 2006, 44 (10): 1659-1666. (SCI, IF=4.679, JCR Q1) 被引频次：57

22. Shui Guan, Bao YM, Jiang B, An LJ. Protective effect of protocatechuic acid from Alpinia oxyphylla on hydrogen peroxide-induced oxidative PC12 cell death. European Journal of Pharmacology, 2006, 538 (1-3): 73-79. (SCI, IF=5.195, JCR Q2) 被引频次：112

23. An LJ, Guan S, Shi GF, Bao YM, Duan YL, Jiang B. Protocatechuic acid from Alpinia oxyphylla against MPP+-induced neurotoxicity in PC12 cells. Food and Chemical Toxicology, 2006, 44 (3): 436-443. (SCI, IF=5.572, JCR Q1) 被引频次：119

24. 周鑫，关水*，孙长凯*．基于壳聚糖/黄原胶互穿网络的导电水凝胶支架制备及性能研究．材料导报，2022.09.23．(EI)

25. 朱智博，关水*，王树萍，王先犇, 刘天庆, 马学虎．Cs/Gel/HA/MWCNTs支架的制备及其生物相容性评价，高校化学工程学报，2017，31(5)：1143-1149. (EI)

26. 张晓庆，关水*，葛丹，王树萍，刘天庆，马学虎．C-G-Ha-HS支架改性协同原儿茶酸对NS/PCs粘附及定向分化的影响．高校化学工程学报，2014，28(5)：1051-1058．(EI)

27. 王树萍，关水*，徐超，张晓庆, 刘天庆, 马学虎．可降解导电PEDOT/PLLA复合材料的制备及其性能的研究，高校化学工程学报，2014，28(3)：592-599．(EI)

28. 林小敏，关水*，葛丹，刘天庆，马学虎，崔占峰．壳聚糖-明胶-透明质酸-硫酸肝素复合三维支架的生物相容性研究．高校化学工程学报，2012，26(2)：265-271．(EI)

29. 关水*，刘天庆，葛丹，陆瑞欣，马学虎，崔占峰．胶原-壳聚糖复合支架体外三维培养神经干细胞．大连理工大学学报，2011，51(5): 637-643．(EI)

30. 关水*，葛丹，陆瑞欣，刘天庆，马学虎，崔占峰．神经干细胞体外三维药物筛选模型的构建．《中国科技论文在线》学报，2011，6(3)：181-186．

31. 关水*，李海华，葛丹，刘天庆，马学虎．原儿茶酸调节神经干/祖细胞分化的作用研究．中国药理学通报，2012，28（9）：1218-1223．

32. 关水*，刘天庆，葛丹，马学虎，崔占峰．原儿茶酸对体外培养的神经干/祖细胞增殖及凋亡的影响．中国药理学通报，2009，25（4）：448-452．

33. 关水，安利佳．喜树碱生物合成途径及其代谢调控的研究进展．高技术通讯，2004，14（5）：106-110．（EI）

34. 关水，周鑫，孙长凯，闫玉娇，徐卫平，许建强，王仰斌．一种基于壳聚糖/黄原胶互穿网络导电水凝胶及其制备方法．ZL202210595570.4，国家发明专利，中国．

35. 关水，石文龙，孙长凯，许建强，骆航，徐卫平．一种用于增强神经元功能的细胞共培养微流控芯片．ZL202010452731.5，国家发明专利，中国．

36. 关水，骆航，孙长凯，许建强，石文龙，徐卫平．一种模拟脑缺血再灌注病理模型的芯片．ZL202010452500.4，国家发明专利，中国．

37. 关水，徐超，许建强，孙长凯．一种新型PCLT-g-PEDOT导电复合物及其制备方法．ZL201811607999.0，国家发明专利，中国．

38. 关水，孙长凯，徐超，许建强，徐卫平．一种pH敏感型PCA-g-CMCS聚合物及其水凝胶的制备方法．ZL202010679720.0，国家发明专利，中国．

39. 关水，林小敏，刘天庆，马学虎，崔占峰. 一种明胶-壳聚糖-透明质酸-硫酸肝素复合三维支架及其制备方法. ZL201010245091.7，国家发明专利，中国．

40. 关水，刘天庆，李香琴，马学虎，崔占峰. 原儿茶酸在促进神经干细胞体外增殖及诱导分化方面的用途．ZL200710011030.2，国家发明专利，中国．