教育经历：

1998年09月-2002年07月 大连理工大学化工学院生物工程系 生物工程(本科)，导师：杨 青 教授

2002年09月-2008年10月 大连理工大学生物科学与技术学院 生物化工(直博)，导师：杨 青 教授、安利佳 教授

2005年04月-2005年12月 瑞典Uppsala Universitet生物医学中心表面生物技术系 访问学者 导师：Jan-Christer Janson 教授(PhD)

2009年02月-2014年09月 瑞典Karolinska Institutet医学生物化学与生物物理系 博士后
  导师：Elias S.J. Arner 教授(PhD,MD) 

、

学术兼职：

中国生物物理学会 生物微量元素分会    委员  (2021-12---2026-12)

欧洲自由基生物学与医学学会(SfRBM)投票会员  (2022-02---2026-02）voting member

铁生物学与医学学会(BioIron)  投票会员  (2023-03------至今）voting member

中国生物物理学会 氧化还原生物学与医学分会  青年委员  (2024-07---至今)

中国生理学会 基质生物学专业委员会          青年委员  (2016-12---至今)

工作经历：

2014年09月-2020年03月，  大连理工大学 生命与医药学院           科研秘书


2015年06月-2017年06月，  大连理工大学 盘锦校区科研与学科工作部 部长助理 (挂职)

2015年12月-2019年09月，  大连理工大学 生命与医药学院           副教授

2016年09月-至今          大连理工大学 盘锦校区侨联             秘书长

2016年03月-2017年12月，  大连理工大学 盘锦产业技术研究院       院长助理

2018年01月-至今          大连理工大学 盘锦产业技术研究院       副院长

2019年09月-2023年12月，  大连理工大学 生命科学与药学学院       副教授

2023年12月-至今          大连理工大学 化工海洋与生命学院       副教授

学术服务：

2021年08月-至今  EI期刊《精细化工》(生物化工、医药化工)                编委

2022年01月-至今  Frontiers旗下期刊Frontiers in Pharmacology    副编辑、编委（Associate Editor,EMB）

2024年01月-至今  Elsevier旗下期刊Biomedicine & Pharmacotherapy 副编辑、编委（Associate Editor,EMB）

担任STTT、RB、BcP、Food Bioscience, Antioxidants、Nutrients、Biomedicines及Frontiers in Microbiology、Frontiers in Oncology、Frontiers in Immunology、Frontiers in Cell & Developmental Biology、Frontiers in Molecular Biosciences等期刊的审稿编辑（Review Editor）或同行评审（Peer Reviewer）。

学术记录：

个人ORCID: 0000-0002-1289-5943

个人PubMed ID: 58002586

个人Scopus ID: 48061598700

个人Pulons ID: T-7507-2019

Researcher ID: 3024651

https://www.researchgate.net/profile/Jianqiang_Xu3

https://loop.frontiersin.org/people/299382/overview

https://publons.com/researcher/4382717/jianqiang-xu/

http://faculty.dlut.edu.cn/jianqiang_xu/en/index.htm

https://www.semanticscholar.org/author/Jianqiang-Xu/2754072

https//www.webofscience.com/wos/author/record/30404783

https://www.mendeley.com/profiles/jianqiang-xu5/

https://sciprofiles.com/profile/1832946

关于科研：

我们聚焦“肿瘤细胞耐药干预、细胞命运调控机制”，细胞氧化还原系统中的关键硒蛋白TXNRD1/2和GPX1/4为胞内靶标，开展植源性有效成分、FDA-approved小分子药物、含Au/Pt化合物(complex)、免疫佐剂及纳米载体递送系统的药效药理研究，在in vitro 细胞水平实验研究（本实验室）、分子酶学检测验证（本实验室）、in vivo 小动物模型实验验证（校际合作），取得新观察、新进展、新成果。

关于我们：

1. 遴选拔尖本科生开展3-3.5年期科研助手行动：实验室固定成员、参加组会、实验讨论、仪器使用、发表文章；

2. 欢迎学生报考本课题组、接收保送生、攻读硕士学位：生物学_学硕；生物技术与工程_专硕；制药工程_专硕.

关于感悟：

古语有云:  至大无外，至小无内。生物医学药学正是这样一门历久弥新、贴近人体、承接地气的学科。

微小至踪迹漂渺的病毒粒子和细菌真菌，介观放大至蔓布旷野山川的动物植物亦或高维文明生命体系。

人类祖先可能很早就意识到碳基生命的一生短暂和序维单向、认识到宇宙洪荒的亘古恢宏与无限壮丽。

正是人类健康疾病的众多挑战和冗余要求，使得人类不断推进新里程，增进对自身和自然的深入理解。

人生短暂、自然永续。今世一生，研而无憾。生而为人、学而有为。期待你的大成、智慧、灵光闪现！

务必慎重考虑、郑重决定、加入实验室，我们一起进步、攻伐有趣、探索新知、洞悉未知、触碰未来！

代表文章：（# 共同第一作者； * 通讯作者）

2025

(1) R. Yang#, S. Sun#, Q. Zhang#, H. Liu, L. Wang, Y. Meng, N. Chen, Z. Wang, H. Liu, F. Ji, G. He, W. Xu, Z. Ye, J. Zhang, Q. Ma*, J. Xu*. Pharmacological inhibition of TXNRD1 by a small molecule flavonoid butein overcomes cisplatin resistance in lung cancer cells, Biological Trace Element Research. 2025, 203：1949-1960.   [JCR Q2, SCI_IF=3.4]

(2)     S. Guan ^#, *, C. Sun ^#, C. Wen, B. Yao, J. Xu, C. Sun. A multifunctional biomimetic double-layer composite hydrogel with wet adhesion and antioxidant activity for dural repair. Journal of Biomaterials Science, Polymer Edition. 2025, in press (doi.org/10.1080/09205063.2025.2460373)

(3) H. Liu#, S. Sun#, Y. Yang, H. Zhou, W. Shi, Y. Meng, X. Yan, M. Xu, H. Liu, Y. Dai, K. Ma, W. Xu,  S. Guan, C. Hung*, J. Xu*.  FRBM, 2025,  submitted. 

(4) H. Zhou, S. Sun, H. Liu, Y. Xu, R. Yang, T. Li, H. Liu, Y. Dai, S. Guan, W. Xu, J. Xu*.  Manuscript. submitted to FRBM. 2025.

(5) Y. Meng#, S. Sun#, H. Liu, ..... J. Xu*, Current Biology, 2025, in preparation,

(6) Q. Zhang, S. Sun, H. Liu, Z. Wang, et al., 2025, Frontiers in Oncology, 2025, manuscript in preparation. 

(7) G. Wang, S. Sun, H. Liu, Z. Wang, et al., 2025, Antioxidants, 2025, manuscript in preparation. 

2024

(1) W. Shi#, S. Sun#, H. Liu#, Y. Meng, K. Ren, G. Wang, M. Liu, J. Wu, Y. Zhang, H. Huang, M. Shi, W. Xu, Q. Ma, B. Sun, J. Xu*.  Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif. Redox Biology. 2024, 70:103050.  [JCR Q1;  中科院 一 区 TOP, SCI_IF=11.4]

(2) L. Wang#, S. Sun#, H. Liu, Q. Zhang, Y. Meng, F. Sun, J. Zhang, H. Liu, W. Xu, Z. Ye, J. Zhang, B. Sun, J. Xu*. Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells, FEBS Journal. 2024, 291:5276-5289.   [JCR Q1, 中科院 二区, SCI_IF=5.5]

(3)  D. Wang#, F. Zhou#, L. He, X. Wang, L. Song, H. Wang, S. Sun, Z, Guo, K. Ma, J. Xu*, C. Cui*.  AML cell‐derived exosomes suppress the activation and cytotoxicity of NK cells in AML via PD‐1/PD‐L1 pathway. Cell Biology International, 2024, 48(10):1588-1598.   [JCR Q3, SCI_IF=3.3]

(4) S. Sun#, H. Liu#, W. Shi, H. Zhou, H. Wu, W. Xu*, J. Xu*. Protocol for assaying irriversible inhibitors of thioredoxin reductase 1. Star Protocols. 2024, 5(3):103235.    [Cell旗下实验方法新刊，SCI_IF=1.3]

(5)  K. Ma ^#, *, H. Diao ^#, X. Xu, Y. Jin, M. Qiu, Z. Liu, C. Yang, J. Zhao, S. Chai, Q. Fang, Z. Guo, C. Cui, J. Xu, L. Yin*, H. Ma*. Dual-targeting of tumor cells and subcellular endoplasmic reticulum via AgPPIX-based Janus nanoparticles for photodynamic/immunotherapy against TNBC. Nanoscale. 2024, 16(25):12095-12106.

(6) M. Yan, N. Zhang, X. Li, J. Xu, H. Lei, Q. Ma*. Integrating Post-Ionization Separation via Differential Mobility Spectrometry into Direct Analysis in Real Time Mass Spectrometry for Toy Safety Screening. Analytical Chemistry. 2024, 96(1):265-271. [JCR Q1;  中科院 一 区 TOP ]

2023

 (1) M. .Liu#, S. Sun#, Y.   Y. Meng, L. Wang, H. Liu, W. Shi, Q. Zhang, W. Xu, B. Sun, J. Xu*. Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec498 Residue of Cytosolic Selenoprotein Thioredoxin Reductase. Molecules, 2023, 28(19): 6842.  [JCR Q2; SCI_IF=4.9]

(2)  R. Yang#, S. Sun#, Y. Guo, Y. Meng, H. Liu, M. Shi, S. Guan*, J. Xu*. Anti-inflammatory effect of dimethyl fumarate associates with the inhibition of thioredoxin reductase 1 in RAW 264.7 cells. Molecules, 2023, 28:107. [JCR Q2; SCI_IF=4.9]

(3)   H. Wang#, S. Sun#, Y. Ren#, R. Yang, Y. Zong, Q. Zhang, J. Zhao, W. Zhang, W. Xu, S. Guan, J. Xu*, Selenite ameliorates cadmium-induced cytotoxicity through down- regulation of ROS levels and up-regulation of selenoprotein thioredoxin reductase 1 in SH-SY5Y cells, Biological Trace Element Research, 2023, 201:139-148.   [ JCR Q2;  SCI_IF=3.9]

(4)  X. Chen#, S. Sun#, S. Huang#, Y. Liang, H. Yang, L. Lv, J. Shan, J. Xu*, W. Liu*, T. Ma*. Gold(I) selenium N-heterocyclic carbene complexes as potent antibacterial agents against multidrug-resistant gram-negative bacteria via inhibiting thioredoxin reductase, Redox Biology, 2023, 60:102621.    [JCR Q1;   中科院 I 区 TOP, ]

(5) J. Zhang*# , Z. Ye# , L. Bräutigam, P. Chakraborty, Z. Luo, J. Culpepper, M. Aslam, L. Zhang, K. Johansson, J.Z. Haeggström, J. Xu, M. Olsson, D.M. Townsend, S. Mehrotra, R. Morgenstern, K.D. Tew*. A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression. Journal of Biological Chemistry, 2023, 299(8):104920.    [ JCR Q2; 中科院 II 区 TOP ]

(6) J. Zhang*# , Z. Ye# , P. Chakraborty, Z. Luo, J. Culpepper, M. Aslam, L. Zhang, K. Johansson, J.Z. Haeggström, J. Xu, M. Olsson, D.M. Townsend, S. Mehrotra, R. Morgenstern, K.D. Tew*. Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma. Pharmacological Research, 2023, 196:106899.   [JCR Q1; 中科院 I 区 TOP ]

2022

(1)  S. Guan*, Y. Wang, F. Xie, S. Wang, W. Xu, J. Xu*, C. Sun*. Carboxymethyl chitosan and gelatin hydrogel scaffolds incorporated with conductive PEDOT nanoparticles for improved neural stem cell proliferation and neuronal differentiation. Molecules, 2022, 27:8326.  [ JCR Q2;   中科院 III 区 ]

(2) Y. Yan, S. Guan*, S. Wang, J. Xu, C. Sun*. Synthesis and characterization of protocatechuic acid grafted carboxymethyl chitosan with oxidized sodium alginate hydrogel through the Schiff's base reaction.   International Journal of Biological Macromolecules, 2022, 222:2581-2593.   [ JCR Q1;   中科院 II 区 ]

(3) Z. Xu, J. Xu, S. Sun, W. Lin, Y. Li, Q. Lu, F. Li, Z. Yang, Y. Lu, W. Liu*, Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma, Redox Biology, 2022, 54:102351.      [JCR Q1;   中科院 I 区 TOP ]

(4)  Y. Yang#, S. Sun#, W. Xu, Y. Zhang, R. Yang, K. Ma, J. Zhang, J. Xu*, Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin, Antioxidants, 2022, 11:710.    [JCR Q1;   中科院 II 区 ]

(5)   Y. Zhang#, S. Sun#, W. Xu, R. Yang, Y. Yang, J. Guo, S. Guan, K. Ma, J. Xu*, Thioredoxin reductase inhibitor shikonin promotes cell necroptosis via SecTRAPs generation and oxygen-coupled redox cycling, Free Radical Biology & Medicine, 2022, 180:52-62.      [ JCR Q1 TOP;   中科院 II 区 ]

(6)   S. Sun, Y. Zhang, W. Xu, R. Yang, Y. Yang, J. Guo, S. Guan, Q. Ma, K. Ma, J. Zhang, J. Xu*, Plumbagin reduction by thioredoxin reductase 1 possesses synergy effects with GLUT1 Inhibitor on KEAP1-mutant NSCLC cells, Biomedicine & Pharmacotherapy, 2022, 146(33):112546.    [ JCR Q1;   中科院 II 区 ]

2021

(1)   S. Sun, Y. Zhang, W. Xu, Y. Zhang, R. Yang, J. Guo, S. Guan, Q. Ma, K. Ma, J. Xu*, Chlorophyllin inhibits mammalian thioredoxin reductase 1 and triggers cancer cell death, Antioxidants, 2021, 10:1733.     [ JCR Q1;   中科院 II 区 ]

(2)   S. Sun#, W. Xu#, Y. Zhang, Y. Yang, Q. Ma*, J. Xu*, Menadione inhibits thioredoxin reductase 1 via arylation at the Sec498 residue and enhances both NADPH oxidation and superoxide production in Sec498 to Cys498 substitution. Free Radical Biology & Medicine, 2021, 172:482-489.   [ JCR Q1;   中科院 II 区 ]

(3)   K. Ma#, W. Li#, G. Zhu, S. Sun, H. Chi, Y. Yin, H. Diao, X. Xing, Z. Guo, L. Wang, W. Xu, C. Cui, J. Xu*. Functionalized PDA/DEX-PEI@HA nanoparticles combined with sleeping- beauty transposons for multistage targeted delivery of CRISPR/Cas9 gene, Biomedicine & Pharmacotherapy, 2021, 142:112061.  [ JCR Q1;   中科院 II 区 ]

(4)   S. Sun#, W. Xu#, H. Zhou, Y. Zhang, J. Zhang, X. Li, B. Li, K. Ma, J. Xu*, Efficient purification of selenoprotein thioredoxin reductase 1 by using chelating reagents to protect the affinity resins and rescue the enzyme activities, Process Biochemistry, 2021, 101:256-265.  [ JCR Q2;   中科院 III 区 ]

(5)   K. Ma#, W. Li#, G. Zhu, H. Chi, Y. Yin, Y. Li, Y. Zong, Z. Guo, L. Wang, W. Xu, C. Cui, H. Zhou, J. Xu*, PEGylated DOX-coated nano graphene oxide as pH-responsive multifunctional nanocarrier for targeted drug delivery, Journal of Drug Targeting, 2021, 29(8):884-891.    [ JCR Q2;   中科院 III 区 ]

(6)  J. Xu, J. Fang*, How can we improve the design of small molecules to target thioredoxin reductase for treating cancer? Expert Opinion on Drug Discovery, 2021,16(4):331-333.    [ JCR Q1;   中科院 II 区 ]

2011-2020 代表性研究文章

[1] T. Liu, J. Zhang*, X. Han, J. Xu, Y. Wu, J. Fang*, Promotion of HeLa cells apoptosis by cynaropicrin involving inhibition of thioredoxin reductase and induction of oxidative stress, Free Radical Biology & Medicine, 2019, 135:216–226.

[2] Y. Hou, S. Peng, X. Li, J. Yao, J. Xu, J. Fang*, Honokiol alleviates oxidative stress-induced neurotoxicity via activation of Nrf2, ACS Chem. Neurosci., 2018, 9(12):3108-3116.

[3] J. Zhang, D. Duan, J. Xu, J. Fang*, Redox-dependent copper carrier promotes cellular copper uptake and oxidative stress-mediated apoptosis of cancer cells, ACS Appl. Mater. Interfaces, 2018, 10(39):33010-33021.

[4] S. Wang, S. Guan*, J. Xu, W. Li, D. Ge, C. Sun, T. Liu, X. Ma, Neural stem cell proliferation and differentiation in the conductive PEDOT-HA/Cs/Gel scaffold for neural tissue engineering, Biomater. Sci., 2017, 5(10):2024-2034.

[5] J. Xu, Q. Cheng, E.S.J. Arnér*, Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities, Free Radical Biology & Medicine, 2016, 94:110-120. Faculty1000Prime Recommendation 

[6] J. Xu, S. Eriksson, M. Cebula, T. Sandalova, E. Hedström, I. Pader, Q. Cheng, C. Myers, W. Antholine, P. Nagy, U. Hellman, G. Selivanova, Y. Lindqvist, E.S.J. Arnér*, The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death, Cell Death and Disease, 2015, 6:e1616.  Faculty1000Prime Recommendation 

[7] I. Pader#, R. Sengupta#, M. Cebula, J. Xu, J.O. Lundberg, A. Holmgren, K. Johansson, E.S.J. Arnér*, Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase, PNAS, 2014, 111(19):6964-6969.

[8] Y. Shi, F. Nikulenkov, J.Z. Pankau, H. Li, R. Gabdoulline, J. Xu, S. Eriksson, E. Hedström, N. Issaeva, A. Kel, E.S.J. Arnér, G. Selivanova*, ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis, Cell Death & Differentiation, 2014, 21(4):612-623.

[9] S. Iverson, S. Eriksson, J. Xu, P. Justin, T. Emily, T. Mead, E. Mead, M. Capecchi, E.S.J. Arnér, E. Schmidt*, A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage and detoxification, Free Radical Biology & Medicine, 2013, 63:369-380.

[10] R. Engelman, P.W. Shomer, T. Ziv, J. Xu, E.S.J. Arnér, M. Benhar*, Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation, J. Biol. Chem., 2013, 288(16):11312-11324.

[11] M. Dagnell, J. Frijhoff, I. Pader, M. Augsten, B. Boivin, J. Xu, P.K. Mandal, N.K. Tonks, C. Hellberg, M. Conrad, E.S.J. Arnér, A. Ostman*, Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGFβ-receptor tyrosine kinase signaling, PNAS, 2013, 110(33): 13398-13403.

[12] J. Xu, V. Croitoru, D. Rutishauser, Q. Cheng, E.S.J. Arnér*, Wobble decoding by the Escherichia coli selenocysteine insertion machinery, Nucleic Acids Research, 2013, 41(21):9800-9811. 

[13] J. Xu, E.S.J. Arnér*, Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase, Biochemical Pharmacology, 2012, 83:815-820.

[14] X. Peng, J. Xu, E.S.J. Arnér*, Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: Effects related to activity and Sec contents of thioredoxin reductase, Biochem. J., 2012, 447(1):167-174.

[15]  S. P.-Nielsen, T.S. Dexheimer, L. Schultz, W.C. Stafford, Q. Cheng, J. Xu, A. Jadhav, E.S.J. Arnér*, A. Simeonov*, Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay, Free Radical Biology & Medicine, 2011, 50(9):1114-1123.