教育经历：

1986年09月-1992年08月 长庆油田（长庆石油勘探局）子弟学校长庆一小（省重点）班主任：贾惠琴（语文）

1992年09月-1995年08月 长庆油田（长庆石油勘探局）子弟学校长庆一中（省重点）初中部 班主任：蔡 丽 （英语）

1995年09月-1998年08月 长庆油田（长庆石油勘探局）子弟学校长庆一中（省重点）高中部 班主任：张廷海（英语）

1998年09月-2002年08月 大连理工大学化工学院生物工程系 生物工程(本科) 导师：杨 青 教授

2002年09月-2008年10月 大连理工大学  生物科学与工程系 生物化工(直博) 导师：杨 青 教授、安利佳 教授

2005年04月-2005年12月 瑞典Uppsala Universitet生物医学中心 访问学者  导师：Jan-Christer Janson教授(PhD)

(2009年02月-2014年09月 瑞典Karolinska Institutet医学生物化学 博士后
 导师：Elias S. J.  Arner 教授(PhD,MD) 

工作经历：

2014年09月-2015年12月 大连理工大学 生命与医药学院        讲师

2014年09月-2020年03月 大连理工大学 生命与医药学院        科研秘书

2015年06月-2017年06月 大连理工大学(盘锦)科研与学科工作部 部长助理 (挂职)

2015年12月-2019年08月 大连理工大学 生命与医药学院        副教授、硕导

2019年09月-2023年08月 大连理工大学 生命科学与药学学院    副教授、硕导

2023年09月-至今       大连理工大学 化工海洋与生命学院    副教授、硕导

2016年09月-至今       大连理工大学(盘锦)归国华侨联合会   秘书长

学术兼职：

中国生物物理学会 生物微量元素分会            委员 (2021-12---2029-07)

中国生物物理学会 氧化还原生物学与医学分会    委员 (2025-07---2029-07)

中国生理学会 基质生物学专业委员会        青年委员 (2016-12---至今)

国际自由基生物学与医学学会(SfRBM)        投票会员 (2022-02---2029-02）

国际铁生物学与医学学会(BioIron)          投票会员 (2023-03------至今）

辽宁省营养学会专家委员会(科技服务团)     专家委员 (2025-12------至今）

学术服务：

2021年08月-至今 北大核心、EI收录学术期刊《精细化工》(生物化工、医药化工)编委（EMB）

2022年01月-至今 Frontiers旗下期刊Frontiers in Pharmacology(抗癌药物专题)编委（EMB）

2026年01月-至今 TMR旗下期刊BioMedical Engineering Communications（BMEC）编委（EMB）

2026年03月-至今 Elsevier旗下期刊 Free Radical Biology & Medicine（FRBM）编委（EMB）

2026年03月-至今 MDPI旗下期刊 International Journal of Molecular Science 编委（EMB）

担任STTT、CEJ、JHM、RB、IJBM、JAR、BT、BcP、Food Chemistry、Phytomedicine、BBA等期刊审稿人。

担任Wiley、Elsevier、MDPI、ACS、Frontiers多期刊预审(Pre-Checking)及审稿编辑(Review Editor)。

学术记录：

个人ORCID: 0000-0002-1289-5943

个人PubMed ID: 58002586

个人Scopus ID: 48061598700

个人Pulons ID: T-7507-2019

Researcher ID: 3024651

https://www.researchgate.net/profile/Jianqiang_Xu3

https://loop.frontiersin.org/people/299382/overview

https://www.webofscience.com/wos/author/record/T-7507-2019

https://www.semanticscholar.org/author/Jianqiang-Xu/2754072

https://sciprofiles.com/profile/1832946

科研方位：

我们课题组聚焦肺癌、胰腺癌与结直肠癌体系的“肿瘤细胞耐药、细胞命运调控”，关注氧化还原酶和氧化还原系统，以硒蛋白TXNRD1/2和GPX1/4为胞内靶标，研究植源分子结构和FDA-approved分子药物的靶向作用机制、含Au/Pt化合物(complex)杀癌杀菌作用，纳米药物/载药递送，开展in vitro分子酶学研究、in vitro 细胞实验研究、in vitro 肿瘤球模型研究、in vivo 小动物实验模型验证、参与clinical trial（校院临床合作），取得新观察、新认知、新见解。

一点感悟：

古语有云:  至大无外，至小无内。向内观和向外观，生物学 都是一门历久弥新、承接地气的学科。

微观看病毒细菌真菌古生菌踪迹漂渺，宏观看动物植物蔓布山野河川，介观互联生命多样而瑰丽。

人类初生，其道大光。先祖甚早意识到碳基生命单薄纤弱短暂，宇宙洪荒的亘古恢宏、无限壮丽。

执念人类健康共同体，解读健康秘籍、解锁疾病密码、打开寿命枷锁、为地球文明，开启新旅程。

我们招募：生物学相关专业本科生做长期科研人员！经申请、筛选、可以成为实验室固定成员！继续在本课题组读研究生者：优先！

我们要求：严格遵守生物安全协议、遵照实验室秩序 开展实验、参与组会、讨论结果、总结数据、发表论文、启迪智慧、修养灵性！

我们希望：务必慎重考虑、郑重决定、非诚勿扰。笃定加入实验室 者，我们一起进步、攻伐有趣、探索新知、洞察前路、触碰未来！

研究座席(含本科)：18+ 固定人员坐固定座席。流动人员临时工位，动态调整。

合成生物学实验室(F03-322): 底盘微生物操作、微生物细胞培养、生物样品制备、低温超声破损、低温高速离心、生物色谱(层析)

清洁动物房实验室(F03-326): 跟随大连凌水主校区同步规划建设，规划清洁实验小动物品系，通风恒温恒湿、昼夜光照、去霉除菌。

代表文章：（# 共同第一； * 通讯作者）

[1] Y. Meng#, S. Sun#, G. Wang, H. Liu, W. Shi, Y. Zhang, Z. Wang, J. Zhao, H. Liu, Z. Yang, K. Ma, W. Xu, J. Gu, J. Xu*, Mutational analysis of TXNRD1 reveals the essential role of Trp114 in TRP14 reduction and identifies key determinants of enzymatic activity and thermostability.   Free Radical Biology & Medicine, 2025, 238:621-629.  

[2] H. Zhou#, S. Sun#, H. Liu#, Y. Xu, R. Yang, T. Li, H. Liu, Y. Dai, S. Guan, W. Xu, J. Xu*.  PK11007 Covalently Inhibits Thioredoxin Reductase 1 to In-duce Oxidative Stress and Autophagy Impairment in NSCLC Cells. Antioxidants. 2025, 14:1222. 

[3] W. Shi#, S. Sun#, H. Liu#, Y. Meng, K. Ren, G. Wang, M. Liu, J. Wu, Y. Zhang, H. Huang, M. Shi, W. Xu, Q. Ma, B. Sun, J. Xu*.  Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif. Redox Biology. 2024, 70:103050.

[4] L. Wang#, S. Sun#, H. Liu, Q. Zhang, Y. Meng, F. Sun, J. Zhang, H. Liu, W. Xu, Z. Ye, J. Zhang, B. Sun, J. Xu*. Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells, FEBS Journal. 2024, 291:5276-5289.

[5]  Y. Yang#, S. Sun#, W. Xu, Y. Zhang, R. Yang, K. Ma, J. Zhang, J. Xu*. Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin, Antioxidants, 2022, 11:710. 

[6]  Y. Zhang#, S. Sun#, W. Xu, R. Yang, Y. Yang, J. Guo, S. Guan, K. Ma, J. Xu*. Thioredoxin reductase inhibitor shikonin promotes cell necroptosis via SecTRAPs generation and oxygen-coupled redox cycling, Free Radical Biology & Medicine, 2022, 180:52-62. 

[7]  X. Yu#, Y. Zhou#, S. Sun, L. Tang, W. Zhang, J Xu*, W. Liu*.  Isoalantolactone induces AML pyroptosis and potentiates α-PD-1 efficacy by targeting selenoprotein TXNRD1. Acta Pharmaceutica Sinica B. 2026, 16(4):2317-2331.

授权发明专利：6+  

年度代表文章：                  #共同第一； *通讯作者

2026

(1)  H. Shi, P. Xie, X. Li, L. Lai, Q. Dang, Z. Gou, Z. Liao, Q. He, W. Guo, Z. Ding, S. Wu, Y. Chen, Z. Lin, Y. Wen, Y. Huang, Y. Chen, J Xu, Y. Wang*, C. Huang*, Carbon Nanoparticle-Fe (II) Complex for Ferroptosis Therapy in Refractory Solid Tumors: A Phase I Trial. STTT, 2026, in press 

(2) X. Yu#, Y. Zhou#, S. Sun, L. Tang, W. Zhang, J Xu*, W. Liu*.  Isoalantolactone induces AML pyroptosis and potentiates α-PD-1 efficacy by targeting selenoprotein TXNRD1. Acta Pharmaceutica Sinica B. 2026, 16(4):2317-2331.  [JCR Q1;  中科院 一 区 TOP,  SCI_2024_IF=14.6] 

(3) Na Chen, Hao Wu, Shibo Sun, Zihan Wang, .....Weiping Xu, J. Xu*.  JBC, 2026,  under review

(4) Hao Wu, Na Chen, Shibo Sun, Zihan Wang, ......Weiping Xu, J. Xu*.  FRBM, 2026, submitted

(5) Siyi Wang, Shuangyan Wang,  Shibo Sun, ......Weiping Xu,  J. Gu*, J. Xu* 2026.  EJP, 2026, submitted

(6) Jinduo Feng, Xiangyou Chu, L Min, S. Wang, Shibo Sun, ............Weiping Xu,  J. Gu*, J. Xu* 2026, ABB, revision

(7) ..., ....J. Xu*. C. Huang*.  Cellular Signalling, 2026, revision

(8)  Zihan Wang, Shibo Sun, Na Chen, Hao Wu,.......Weiping Xu, J. Xu*.  FRBM, 2026, submitted

(9) Haowen Liu#, S. Sun#, Y. Yang, H. Zhou, W. Shi, X. Yan, M. Xu, H. Liu, K. Ma, W. Xu,  S. Guan, C. Hung*, J. Xu*.  IJBM, 2026, submitted.

(10) Y. Meng, Shibo Sun, Weiping Xu, J. Xu*.  JBC, 2026, manuscript

2025

(1) H. Zhou#, S. Sun#, H. Liu#, Y. Xu, R. Yang, T. Li, H. Liu, Y. Dai, S. Guan, W. Xu, J. Xu*.  PK11007 Covalently Inhibits Thioredoxin Reductase 1 to In-duce Oxidative Stress and Autophagy Impairment in NSCLC Cells. Antioxidants. 2025, 14:1222.    [JCR Q1;  中科院 二 区, SCI_2024_IF=6.6]        五年平均影响因子7.3

(2) J. Gu#, Z. Dai#, T. Shen, X. Chen, Z. Yang*, S. Sun, D. Chen, H. Luo, X. Wang*, J. Xu*. CDK4/6 and BET inhibitors synergistically suppress pancreatic tumor growth and epithelial-to-mesenchymal transition by regulating the GSK3β-mediated Wnt/β-catenin pathway. Cancer Drug Resistance, 2025,  8:52.   [JCR Q1;  中科院 二 区, SCI_2024_IF=5.2]        五年平均影响因子5.3

(3) X. Chen#, L. Lv#, J Xu#, J. Shi, X. Chen, G. Zi, Y. Wu, Shibo Sun, Y. Pang, Q. Song, L. Ma, S. Wei*, T. Ma*, W. Liu*.  Au(III) Schiff base complexes as oxidoreductase inhibitors against car bapenem- and colistin-resistant Gram-negative bacteria via targeting redox active motifs. Redox Biology. 2025, 86:103800.   [JCR Q1;  中科院 一 区 TOP, SCI_2024_IF=11.9]   五年平均影响因子13.1

(4) Y. Meng#, S. Sun#, G. Wang, H. Liu, W. Shi, Y. Zhang, Z. Wang, J. Zhao, H. Liu, Z. Yang, K. Ma, W. Xu, J. Gu, J. Xu*, Mutational analysis of TXNRD1 reveals the essential role of Trp114 in TRP14 reduction and identifies key determinants of enzymatic activity and thermostability.   Free Radical Biology & Medicine, 2025, 238:621-629. [JCR Q1, 中科院 二区 TOP, SCI_IF=8.2]   五年平均影响因子 8.6  

(5) Z. Zhang, B. Fan, C. Zhou, P. Zhang, C. Liu, Y. Xiang, W. Xia, G. Sun, Y. You, D. Li, J. Xu*, J. Huang*, C. Huang*. Biomimetic Selenium‐Nanocomposites Alleviate MASH by Modulating Lipid and Iron Homeostasis. Advanced Healthcare Materials 2025, 14(19):e2500467.     [JCR Q1, 中科院 二区 TOP, SCI_2024_IF=9.6]   五年平均影响因子10.8  

(6) R. Yang#, S. Sun#, Q. Zhang#, H. Liu, L. Wang, Y. Meng, N. Chen, Z. Wang, H. Liu, F. Ji, G. He, W. Xu, Z. Ye, J. Zhang, Q. Ma*, J. Xu*.  Pharmacological inhibition of TXNRD1 by a small molecule flavonoid butein overcomes cisplatin resistance in lung cancer cells, Biological Trace Element Research. 2025, 203:1949-1960.   [JCR Q2, SCI_2024_IF=3.6]    五年平均影响因子3.8

2024

(1) W. Shi#, S. Sun#, H. Liu#, Y. Meng, K. Ren, G. Wang, M. Liu, J. Wu, Y. Zhang, H. Huang, M. Shi, W. Xu, Q. Ma, B. Sun, J. Xu*.  Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif. Redox Biology. 2024, 70:103050.

(2) L. Wang#, S. Sun#, H. Liu, Q. Zhang, Y. Meng, F. Sun, J. Zhang, H. Liu, W. Xu, Z. Ye, J. Zhang, B. Sun, J. Xu*. Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells, FEBS Journal. 2024, 291:5276-5289.

(3)  D. Wang#, F. Zhou#, L. He, X. Wang, L. Song, H. Wang, S. Sun, Z, Guo, K. Ma, J. Xu*, C. Cui*.  AML cell‐derived exosomes suppress the activation and cytotoxicity of NK cells in AML via PD‐1/PD‐L1 pathway. Cell Biology International, 2024, 48(10):1588-1598. 

(4) S. Sun#, H. Liu#, W. Shi, H. Zhou, H. Wu, W. Xu*, J. Xu*. Protocol for assaying irriversible inhibitors of thioredoxin reductase 1. STAR Protocols. 2024, 5(3):103235. 

(5) M. Yan, N. Zhang, X. Li, J. Xu, H. Lei, Q. Ma*. Integrating Post-Ionization Separation via Differential Mobility Spectrometry into Direct Analysis in Real Time Mass Spectrometry for Toy Safety Screening. Analytical Chemistry. 2024, 96(1):265-271.

2023

 (1) M. .Liu#, S. Sun#, Y.   Y. Meng, L. Wang, H. Liu, W. Shi, Q. Zhang, W. Xu, B. Sun, J. Xu*. Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec498 Residue of Cytosolic Selenoprotein Thioredoxin Reductase. Molecules, 2023, 28(19): 6842.

(2)  R. Yang#, S. Sun#, Y. Guo, Y. Meng, H. Liu, M. Shi, S. Guan*, J. Xu*. Anti-inflammatory effect of dimethyl fumarate associates with the inhibition of thioredoxin reductase 1 in RAW 264.7 cells. Molecules, 2023, 28:107.

(3)   H. Wang#, S. Sun#, Y. Ren#, R. Yang, Y. Zong, Q. Zhang, J. Zhao, W. Zhang, W. Xu, S. Guan, J. Xu*, Selenite ameliorates cadmium-induced cytotoxicity through down- regulation of ROS levels and up-regulation of selenoprotein thioredoxin reductase 1 in SH-SY5Y cells, Biological Trace Element Research, 2023, 201:139-148.

(4)  X. Chen#, S. Sun#, S. Huang#, Y. Liang, H. Yang, L. Lv, J. Shan, J. Xu*, W. Liu*, T. Ma*. Gold(I) selenium N-heterocyclic carbene complexes as potent antibacterial agents against multidrug-resistant gram-negative bacteria via inhibiting thioredoxin reductase, Redox Biology, 2023, 60:102621.

(5) J. Zhang*# , Z. Ye# , L. Bräutigam, P. Chakraborty, Z. Luo, J. Culpepper, M. Aslam, L. Zhang, K. Johansson, J.Z. Haeggström, J. Xu, M. Olsson, D.M. Townsend, S. Mehrotra, R. Morgenstern, K.D. Tew*. A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression. Journal of Biological Chemistry, 2023, 299(8):104920. 

(6) J. Zhang*# , Z. Ye# , P. Chakraborty, Z. Luo, J. Culpepper, M. Aslam, L. Zhang, K. Johansson, J.Z. Haeggström, J. Xu, M. Olsson, D.M. Townsend, S. Mehrotra, R. Morgenstern, K.D. Tew*. Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma. Pharmacological Research, 2023, 196:106899.

2023年之前论文（列举 <20篇）

[01] Z. Xu, J. Xu, S. Sun, W. Lin, Y. Li, Q. Lu, F. Li, Z. Yang, Y. Lu, W. Liu*, Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma, Redox Biology, 2022, 54:102351. 

[02] Y. Yang#, S. Sun#, W. Xu, Y. Zhang, R. Yang, K. Ma, J. Zhang, J. Xu*, Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin, Antioxidants, 2022, 11:710. 

[03] Y. Zhang#, S. Sun#, W. Xu, R. Yang, Y. Yang, J. Guo, S. Guan, K. Ma, J. Xu*,Thioredoxin reductase inhibitor shikonin promotes cell necroptosis via SecTRAPs generation and oxygen-coupled redox cycling, Free Radical Biology & Medicine,2022, 180:52-62. 

[04] S. Sun, Y. Zhang, W. Xu, R. Yang, Y. Yang, J. Guo, S. Guan, Q. Ma, K. Ma, J. Zhang, J. Xu*, Plumbagin reduction by thioredoxin reductase 1 possesses synergy effects with GLUT1 Inhibitor on KEAP1-mutant NSCLC cells, Biomedicine & Pharmacotherapy, 2022, 146(33):112546. 

[05] S. Sun, Y. Zhang, W. Xu, Y. Zhang, R. Yang, J. Guo, S. Guan, Q. Ma, K. Ma, J. Xu*, Chlorophyllin inhibits mammalian thioredoxin reductase 1 and triggers cancer cell death, Antioxidants, 2021, 10:1733.

[06] S. Sun#, W. Xu#, Y. Zhang, Y. Yang, Q. Ma*, J. Xu*, Menadione inhibits thioredoxin reductase 1 via arylation at the Sec498 residue and enhances both NADPH oxidation and superoxide production in Sec498 to Cys498 substitution. Free Radical Biology & Medicine, 2021, 172:482-489.

[07] S. Sun#, W. Xu#, H. Zhou, Y. Zhang, J. Zhang, X. Li, B. Li, K. Ma, J. Xu*, Efficient purification of selenoprotein thioredoxin reductase 1 by using chelating reagents to protect the affinity resins and rescue the enzyme activities, Process Biochemistry, 2021, 101:256-265. 

[08] J. Xu, Q. Cheng, E.S.J. Arnér*, Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities, Free Radical Biology & Medicine, 2016, 94:110-120. Faculty1000Prime Recommendation 

[09] J. Xu, S. Eriksson, M. Cebula, T. Sandalova, E. Hedström, I. Pader, Q. Cheng, C. Myers, W. Antholine, P. Nagy, U. Hellman, G. Selivanova, Y. Lindqvist, E.S.J. Arnér*, The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death, Cell Death and Disease, 2015, 6:e1616.  Faculty1000Prime Recommendation 

[10] I. Pader#, R. Sengupta#, M. Cebula, J. Xu, J.O. Lundberg, A. Holmgren, K. Johansson, E.S.J. Arnér*, Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase, PNAS, 2014, 111(19):6964-6969.

[11] Y. Shi, F. Nikulenkov, J.Z. Pankau, H. Li, R. Gabdoulline, J. Xu, S. Eriksson, E. Hedström, N. Issaeva, A. Kel, E.S.J. Arnér, G. Selivanova*, ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis, Cell Death & Differentiation, 2014, 21(4):612-623.

[12] S. Iverson, S. Eriksson, J. Xu, P. Justin, T. Emily, T. Mead, E. Mead, M. Capecchi, E.S.J. Arnér, E. Schmidt*, A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage and detoxification, Free Radical Biology & Medicine, 2013, 63:369-380.

[13] R.Engelman, P.W. Shomer, T.Ziv, J. Xu, E.S.J. Arnér,M.Benhar*, Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation, J. Biol. Chem., 2013, 288(16):11312-11324.

[14] M. Dagnell, J. Frijhoff, I. Pader, M. Augsten, B. Boivin, J. Xu, P.K. Mandal, N.K. Tonks, C. Hellberg, M. Conrad, E.S.J. Arnér, A. Ostman*, Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGFβ-receptor tyrosine kinase signaling, PNAS, 2013, 110(33): 13398-13403.

[15] J. Xu, V. Croitoru, D. Rutishauser, Q. Cheng, E.S.J.Arnér*, Wobble decoding by the Escherichia coli selenocysteine insertion machinery, Nucleic Acids Research, 2013, 41(21):9800-9811. 

[16] J. Xu, E.S.J.Arnér*, Pyrroloquinolinequinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase, Biochemical Pharmacology, 2012, 83:815-820.

[17] X. Peng, J. Xu, E.S.J. Arnér*, Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: Effects related to activity and Sec contents of thioredoxin reductase, Biochem. J.,2012, 447(1):167-174.

[18]  S.P.-Nielsen, T.S. Dexheimer, L. Schultz, W.C. Stafford, Q. Cheng, J. Xu, A.Jadhav, E.S.J. Arnér*, A.Simeonov*,Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay, Free Radical Biology & Medicine,2011,50(9):1114-1123.