论文名称：Small Molecules to Target the Selenoprotein Thioredoxin Reductase
论文类型：期刊论文
发表刊物：CHEMISTRY-AN ASIAN JOURNAL
收录刊物：SCIE、PubMed、Scopus
卷号：13
期号：23
页面范围：3593-3600
ISSN号：1861-4728
关键字：fluorescent probes; natural products; prodrugs; redox chemistry; selenoproteins
摘要：The selenoprotein thioredoxin reductase (TrxR) enzymes are the only identified proteins that maintain thioredoxin (Trx) proteins in a reduced state under physiological conditions, and consequently play a pivotal role in the regulation of various cellular redox signaling pathways involved in cell differentiation, growth, and death. The elevated expression of TrxR enzymes has been observed in different types of cancer cells, and this overexpression is of pathological significance in maintaining tumor phenotypes, such as uncontrolled proliferation and resistance to apoptosis. Herein, we discuss recent advances in the study of TrxR, including classic assays of TrxR, the emerging chemical tools of TrxR, and small molecules that target TrxR as potential anticancer agents.
发表时间：2018-12-04