论文类型：期刊论文
发表刊物：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
收录刊物：PubMed、SCIE
卷号：16
期号：4
页面范围：803-806
ISSN号：0960-894X
关键字：DNA cleavage; hydrolysis; naphthalimide; intercalator; selectivity; RNA
摘要：A strategy of dimethylamino alkyldiimide conjugated with an intercalator of naphthalimide for hydrolysis of DNA was suggested and evaluated. 4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently. (c) 2005 Elsevier Ltd. All rights reserved.