论文名称：Targeting Thioredoxin Reductase by Ibrutinib Promotes Apoptosis of SMMC-7721 Cells
论文类型：期刊论文
发表刊物：The Journal of pharmacology and experimental therapeutics
收录刊物：PubMed
卷号：369
期号：2
页面范围：212-222
ISSN号：1521-0103
关键字：cell death,drug targeting,molecular drug targeting
摘要：Ibrutinib (IBT), the first-in-class inhibitor of Bruton's tyrosine kinase (BTK), has demonstrated clinical activity against various B-cell malignancies. Aside from its therapeutic mechanism through BTK inhibition, IBT has other target sites reported for cancer therapy, leading us to investigate whether IBT has unreported targets. Our study revealed that IBT can inhibit SMMC-7721 cells through irreversible inhibition of mammalian thioredoxin reductase enzymes. Further study demonstrated that IBT can cause cellular reactive oxygen species elevation and induce cancer cell apoptosis. The discovery of a new target of IBT sheds light on better understanding its anticancer mechanisms and provides a theoretical foundation for its further use in clinical therapy.Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics.
发表时间：2019-05-01