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Indexed by:期刊论文

Date of Publication:2021-02-07

Journal:CHEMICAL ENGINEERING JOURNAL

Volume:390

ISSN No.:1385-8947

Key Words:Electrospun fibrous mat; Metal-organic framework; Antibacterial activity; Proteomic; Wound dressing

Abstract:The fabrication of functional wound dressings to control skin bacterial infection is of vital importance. In this work, a silver (I) metal-organic framework Ag-2[HBTC][im] (1) and polylactic acid composite fibrous mat (1-PLA) with efficient antimicrobial capability was prepared via an electrospinning process. 1 possesses three-dimensional framework assembled from rod-shaped molecular building blocks which consist of Ag (I) ions, 1,3,5-benzenetricarboxylate (HBTC) and imidazole (im) ligand. The as-prepared 1-PLA shows unique broadspectrum antibiosis potency against Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus) and Mycobacterium smegmatis (M. smegmatis). Proteomic investigations enable to gain insight on the antimicrobial mechanism of 1-PLA composite indicating that the dissipation of proton motive force, destroying of energy metabolism, decreasing or losing of transport system may be associated with the antibacterial action. Furthermore, in vivo experiments indicate that the 1-PLA electrospun fibrous mat can significantly accelerate the healing rate of infection wounds in rats. This study demonstrated the electrospun fibrous mat with efficient on-demand antibacterial properties is promising for practical application in anti-infective therapy.