Release Time:2021-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2021-02-07

Journal: DALTON TRANSACTIONS

Volume: 49

Issue: 37

Page Number: 13044-13051

ISSN: 1477-9226

Abstract: With the rapid evolution of antibiotic resistant bacteria, it has become more and more difficult to treat bacterial infection with traditional antibiotics. Therefore, new strategies with high antibacterial efficiency are urgently needed to combat bacteria effectively. Herein, Fe3O4@copper(II) metal-organic framework Cu-3(BTC)(2) (Cu-BTC) core shell structured magnetic microspheres were prepared via a layer by layer growth process. The as-prepared Fe3O4@Cu-BTC possessed a unique broad-spectrum antibacterial potency against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus). The slowly released copper ions and enhanced reactive oxygen species (ROS) generation by facilitating the effective separation and transfer of photoexcited electron-hole pairs played a role in the antibacterial activity of Fe3O4@Cu-BTC. Copper ions released from Fe3O4@Cu-BTC adhered to the negatively charged bacterial cell, interacted with the bacterial membrane, destroyed the integrity of the membrane which resulted in leakage of bacterial content and then generated ROS to damage DNA, thus leading to cell death. Accordingly, this study provides a competitive strategy for preparing recyclable antibacterial materials that are endowed with targeted antibacterial therapy.