教授 博士生导师 硕士生导师
主要任职: 医学部党委书记兼常务副部长
性别: 男
毕业院校: 复旦大学
学位: 博士
所在单位: 生物医学工程学院
学科: 生物医学工程
电子邮箱: krqin@dlut.edu.cn
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论文类型: 会议论文
发表时间: 2021-06-04
卷号: 2018-June
页面范围: 142-146
摘要: In this study, two novel hydrodynamics-based radial microarrays are proposed to trap single cells with high trapping efficiency and negligible shear stress. Both microarrays are designed based on a single cell trapping microdevice we designed using a combination of the stagnation point flow and the boundary effect. For each microarray, the efficiency of trapping is evaluated with the flow velocity distribution in the microfluidic channel through two models: an initial model calculates the velocity distribution without cell trapping; in the contrary, a trapping model estimates the velocity distribution when a cell is trapped at the stagnation point. In both models, the flow velocity distribution is obtained using the computational fluid dynamics (CFD) package ANSYS 16.0. We conclude that both microarrays can capture single cells with high trapping success rate and negligible shear stress, which would be effective experimental platforms to study single cell behaviors in response to extracellular stimuli.