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论文类型： 期刊论文

发表时间： 2014-06-21

发表刊物： JOURNAL OF THEORETICAL BIOLOGY

收录刊物： SCIE、PubMed、Scopus

卷号： 351

页面范围： 58-66

ISSN号： 0022-5193

关键字： Human spermatozoa; Calcium signaling; Progesterone; Mathematical modeling

摘要： Calcium ion is a secondary messenger of mammalian spermatozoa. The dynamic change of its concentration plays a vital role in the process of sperm motility, capacitation, acrosome and fertilization. Progesterone released by the cumulus cells, as a potent stimulator of fertilization, can activate the calcium channels on the plasma membrane, which in turn triggers the dynamic change of intracellular calcium concentration. In this paper, a mathematical model of calcium dynamic response in mammalian spermatozoa induced by progesterone is proposed and numerical simulation of the dynamic model is conducted. The results show that the dynamic response of calcium concentration predicted by the model is in accordance with experimental evidence. The proposed dynamic model can be used to explain the phenomena observed in the experiments and predict new phenomena to be revealed by experimental investigations, which will provide the basis to quantitatively investigate the fluid mechanics and biochemistry for the sperm motility induced by progesterone. (C) 2014 Elsevier Ltd. All rights reserved.