点击次数：

论文类型： 期刊论文

发表时间： 2013-12-01

发表刊物： JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

收录刊物： SCIE、EI、Scopus

卷号： 135

期号： 12

ISSN号： 0148-0731

关键字： dynamic biochemical signal; transport; steady flow; shallow Y-shaped microfluidic channel; Taylor-Aris dispersion; molecular diffusion

摘要： Dynamic biochemical signal control is important in in vitro cell studies. This work analyzes the transportation of dynamic biochemical signals in steady and mixing flow in a shallow, Y-shaped microfluidic channel. The characteristics of transportation of different signals are investigated, and the combined effect of transverse diffusion and longitudinal dispersion is studied. A method is presented to control the widths of two steady flows in the mixing channel from two inlets. The transfer function and the cutoff frequency of the mixing channel as a transmission system are presented by analytically solving the governing equations for the time-dependent Taylor-Aris dispersion and molecular diffusion. The amplitude and phase spectra show that the mixing Y-shaped microfluidic channel acts as a low-pass filter due to the longitudinal dispersion. With transverse molecular diffusion, the magnitudes of the output dynamic signal are reduced compared to those without transverse molecular diffusion. The inverse problem of signal transportation for signal control is also solved and analyzed.