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论文类型： 期刊论文

发表时间： 2013-07-01

发表刊物： MATHEMATICAL BIOSCIENCES

收录刊物： SCIE、EI、PubMed、Scopus

卷号： 244

期号： 1

页面范围： 47-57

ISSN号： 0025-5564

关键字： Intracellular calcium ion concentration; Electrical stimulation; Calcium ion channels; Fibroblasts; Dynamic model

摘要： Regulation of intracellular calcium ion concentration ([Ca2+](in)) in fibroblasts induced by exogenous electrical stimulation could be applied to control gene expressions selectively which in turn modulate the function of the fibroblasts. Regarding the mechanism for electric-field-induced Ca2+ influx via voltage-gated Ca2+ channels and/or stretch-activated cation channels in the fibroblasts, a dynamic mathematical model is proposed to quantify the [Ca2+](in) dynamics in response to direct current or alternating current electric fields. Simulation results demonstrate that the changes in [Ca2+](in) predicted by our dynamic model are consistent with the experimental data in the literature. The proposed dynamic model could provide not only more insights into the electric-field-induced intracellular Ca2+ response but also a quantitative way to regulate the [Ca2+](in) dynamics by controlling the external electrical stimulation. (c) 2013 Elsevier Inc. All rights reserved.