李广哲，教授、博士生导师；

中国化学会、日本化学会、日本药学会、日本癌分子靶向治疗学会会员；

邮箱：liguangzhe@dlut.edu.cn

【个人经历】

• 2002.09－2006.07  大连理工大学制药工程，工学学士

• 2006.09－2009.07  大连理工大学药物工程，理学硕士

• 2009.10－2013.03  日本东北大学药学研究科，药学博士

• 2013.04－2014.04  日本东北大学药学研究科，助教

• 2014.05－2015.09  东京工业大学化学生命科学研究所，助教

• 2015.12－2021.12　大连理工大学化工学院药学系，副教授

• 2022.01－至今　　大连理工大学化工学院药学系，教授

• 2016.10－至今　　大连理工大学化工学院药学系教工党支部书记兼副系主任

【研究内容】

面向人民生命健康，围绕恶性肿瘤等重大疾病治疗的新靶点、新药物和新方法开展应用基础研究：

1. 分子靶向抗肿瘤药物的研究：HIF-1 抑制剂、热休克蛋白HSP90、HSP60 抑制剂等；

2. 用于光动力、声动力治疗的光敏剂、声敏剂的设计与开发；

3. BNCT 治疗中含硼药物的设计与开发；

4.药物活性分子导向的绿色有机合成新方法的开发。

【代表性研究成果】

18. Wang, L.; Li, G.*; Cao, L.; Shao, K.; Li, Y.; Zhang, X.; Zhao, J.; Zhao, W.* A novel water-soluble chlorin-based photosensitizer for low-fluence photodynamic therapy. ACS Pharmacol. Transl. Sci., 2022, 2, 110-117.

17. Li, G.*; Yu, G.; Wang, C.; Morita,T.; Zhang, X.; Nakamura, H.* Copper(i)-catalysed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with phosphites. Org. Biomol. Chem., 2022, 20, 113-116.

16. Wang, L.; Li, G.*; Cao, L.; Dong, Y.; Wang, Y.; Wang, S.; Li, Y.; Guo, X.; Zhang, Y.; Sun, F.; Du, X.; Su, J.; Li, Q.; Peng X.; Shao, K.*; Zhao, W.* An Ultrasound-Driven Immune Boosting Molecular Machine for Systemic Tumor Suppression. Sci. Adv., 2021, 7, eabj4796.

15. Li, G.*; Shao, Y.; Pan Y.; Li, Y.; Wang, Y.; Wang, L.; Wang, X.; Shao, K.; Wang, S.; Liu, N.; Zhang, J.; Zhao, W.; Nakamura, H. Total synthesis and biological evaluation of 7-Hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy. Bioorg. Med. Chem. Lett., 2021, 50, 128338.

14. Wang, S.; Wang, X.; Shao, Y.; Shao, K.; Wang, Y.; Guo, X.; Dong, H.; Zhao, W.; Li, Y.; Li, G.* Synthesis and evaluation of 3-(phenylethynyl)-1,1′-biphenyl-2-carboxylate derivatives as new HIF-1 inhibitors. Bioorg. Chem., 2021, 116, 105298.

13. Li, G.*; Wang, C.; Li, Y.; Shao, K.; Yu, G.; Wang, S.; Guo, X.; Zhao, W.; Nakamura, H. Zinc(ii)-catalyzed intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines with diverse carbon pronucleophiles: facile access to functionalized tetrahydroquinolines. Chem. Commun., 2020, 7333-7336.

12. Dong, Y.; Li, G.*; Wang, L.; Cao, L.; Li, Y.; Zhao, W.* Anti-tumor evaluation of a novel methoxyphenyl substituted chlorin photosensitizer for photodynamic therapy. J. Photoch. Photobio. B, 2020, 211, 112015.

11. Li, G.*; Dong, H.; Ma, Y.; Shao, K.; Li, Y.; Wu, X.; Wang, S.; Shao, Y.; Zhao, W. Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors. Bioorg. Med. Chem. Lett., 2019, 29, 2327-2331.

10. Wang, S.; Liu, L.; Guo, X.; Li, G.*; Wang, X.; Dong, H.; Li, Y.; Zhao, W. Synthesis of novel natural product-like diaryl acetylenes as hypoxia inducible factor-1 inhibitors and antiproliferative agents. RSC Adv., 2019, 9, 13878-13886.

9. Li, Y.; Li, G.*; Dong, Y.; Ma, X.; Dong, H.; Wu, Q.; Zhao, W.* Orobanone analogues from acid-promoted aromatization rearrangement of curcumol inhibit hypoxia-inducible factor-1 (HIF-1) in cell-based reporter assays. Bioorg. Chem., 2019, 85, 357-363.

8. Li, G.; Shao, K.; SokkeUmeshappa C. Recent progress in blood-brain barrier transportation research. In : Gao H, Gao X(Eds.), Brain Targeted Drug Delivery System, Elsevier, 2019, 33-51.

7. Li, G.; Ban, H.; Nakamura, H. Design of Carborane‐Based Hypoxia‐Inducible Factor Inhibitors. In: Evamarie H, Clara V T (Eds.), Boron‐Based Compounds: Potential and Emerging Applications in Medicine, Wiley, 2018, 35-59. 

6. Li, G.; Nakamura, H.* Synthesis of 2-Indolyltetrahydroquinolines by Zinc(II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N-Propargylanilines with Indoles. Angew. Chem. Int. Ed., 2016, 55, 6758-6761.

5. Li, G.; Azuma, S.; Sato, S.; Minegishi, H.; Nakamura, H.* ortho-Carboranylphenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity and heat shock protein (HSP) 60 chaperon activity. Bioorg. Med. Chem. Lett., 2015, 25, 2624-2628.

4. Li, G.; Azuma, S.; Minegishi, H.; Nakamura, H. Synthesis and biological evaluation of meta-carborane-containing phenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity. J. Organomet. Chem., 2015, 798, 189-195.

3. Li, G.; Arisawa, M.; Yamaguchi, M.* Rhodium-catalyzed synthesis of unsymmetrical di(aryl/heteroaryl) methanes using aryl/heteroarylmethyl ketones via CO-C bond cleavage. Chem. Commun., 2014, 50, 4328-4330.

2. Li, G.; Arisawa, M.; Yamaguchi, M.* Rhodium-Catalyzed Synthesis and Reactions of N-Acylphthalimides. Asian J. Org. Chem., 2013, 2, 983-988.

1. Arisawa, M.*; Li, G.; Yamaguchi, M.* Rhodium-catalyzed synthesis of 2,3-diaryl-1,4-diketones via oxidative coupling of benzyl ketones using α-thioketone oxidizing reagent. Tetrahedron Lett., 2013, 54, 1298-1301.

【个人奖励】

• 2016 年，入选大连理工大学“星海学者”人才培育计划“星海骨干”

• 2018 年，入选大连理工大学“星海学者”人才培育计划“星海优青”

• 2016 年，大连理工大学青年教师讲课竞赛二等奖

• 2019 年，全国高等学校药学类专业青年教师教学能力大赛 一等奖

• 2019 年，全国高等学校药学类专业青年教师微课教学大赛 特等奖

2022 年招收药学（学硕），药物工程（学硕），生物与医药（专硕）硕士研究生，

欢迎制药工程、药学、化学、化工、生物工程、生物学等相关专业的考生报考！