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个人信息Personal Information
特聘研究员A岗
博士生导师
硕士生导师
性别：男
毕业院校：东京大学
学位：博士
所在单位：化学学院
办公地点：化学楼118b
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Photocatalytic Generation of pi-allyltitanium Complexes via Radical Intermediates
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论文类型：期刊论文
发表时间：2021-04-09
发表刊物：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷号：60
期号：3
页面范围：1561-1566
ISSN号：1433-7851
关键字：allylic compounds; dienes; photocatalysis; radicals; titanium
摘要：The addition of pi-allylmetal complexes to carbonyls is the most important route to homoallylic alcohols. This study reports the first photocatalytic generation of pi-allyltitanium complexes by a radical strategy. This novel strategy enables the three-component allylation of carbonyls with 1,3-butadiene, providing rapid access to valuable homoallylic alcohols (over 60 examples). The exceptional regio- and diastereoselectivity provided by dual photoredox/Ti catalysis is comparable to that of the Cr-catalyzed Nozaki-Hiyama-Kishi allylation reaction.