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论文类型：期刊论文

发表时间：2018-02-15

发表刊物：BIOORGANIC & MEDICINAL CHEMISTRY

收录刊物：SCIE、PubMed

卷号：26

期号：4

页面范围：931-937

ISSN号：0968-0896

关键字：Pd2+ detection; Near-infrared fluorescence; Water solubility; Naphthofluorescein; Imaging

摘要：Palladium (Pd) is widely used in chemistry, biology, environmental science etc., and Pd2+ is the most plenitudinous oxidation state of the Pd that can exist under physiological conditions or in living cells, which could have adverse effects on both our health and environment. Thus, it is of great significance to monitor the changes of Pd2+. Hence, a novel near-infrared fluorescent probe M-PD has been developed for selective detection of Pd2+ based on naphthofluorescein in this work. The result demonstrated that M-PD exhibited favorable properties for sensing Pd2+ such as excellent water solubility, high selectivity and sensitivity. And the limit of detection was estimated as 10.8 nM, much lower than the threshold in drugs (5-10 ppm) specified by European Directorate for the Quality Control of Medicines. More importantly, detection and recovery experiments of Pd2+ in aspirin aqoeous solution and soil are satisfactory. In addition, M-PD has also been successfully used for near-infrared fluorescence imaging of Pd2+ in living cells, indicating that the probe has better feasibility and application potential in the determination of Pd2+. (C) 2017 Elsevier Ltd. All rights reserved.