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论文类型：期刊论文

发表时间：2007-08-01

发表刊物：BIOORGANIC & MEDICINAL CHEMISTRY

收录刊物：SCIE、PubMed

卷号：15

期号：15

页面范围：5114-5121

ISSN号：0968-0896

关键字：aryl/heteroaryl-imidazonaphthalimides; '4-1' pentacyclic DNA-intercalating agents

摘要：A novel series of '4-1' pentacyclic naphthalimides, where the chromophore consists of a naphthalimide moiety, fused to an imidazole ring containing an unfused aryl or heteroaryl ring, were synthesized and evaluated for in vitro antitumor activity. In general, the new derivatives showed an improved cytotoxic activity over amonafide. DNA binding experiments supported that this class of compounds behaves as effective DNA-intercalating agents. (c) 2007 Elsevier Ltd. All rights reserved.