栾雨时教授长期从事植物分子生物学、基因工程领域的研究工作，在植物非编码RNA、转录因子的发现及功能鉴定方面独树一帜，尤其是以番茄与致病疫霉为试材进行的植物与微生物分子互作研究，结合大量的生物信息学预测、分析以及先进的分子生物学实验技术，取得了众多突破性的成果。陆续得到 8 项国家自然科学基金（重点及面上）项目的支持，目前正在开展的工作有“番茄抗晚疫病关键调控因子的协同免疫机制研究（执行期2023.01-2027.12）”“番茄SCOOP小肽及其受体MIK2调控植株耐盐性的机制（执行期2025.01-2028.12）”；发表SCI收录论文131 篇，有9篇入选ESI高被引。

任教三十余年，讲授过“生物统计学”“普通生物学”“生命科学概论”“细胞生物学” “作物遗传育种学”“植物保护学”等十余门各类课程；主持过多项本科生及研究生的教改项目；多次获得教学质量优良奖。

近年来指导的博士、硕士研究生有6人、7次获得国家奖学金，有2人获得学业奖学金，有17人次被评为优秀研究生，有1人获得辽宁省优秀硕士学位论文，有1人和7人分别获得大连理工大学优秀博士和硕士学位论文；指导的本科生在进行大学生创新项目期间，多数人经过系统的训练有论文成果发表，有1项成果获得辽宁省生命科学创新创业大赛一等奖。目前正在指导3名博士后、1名博士生、8名硕士生。

欢迎有志于从事相关研究的人员加盟（读研有风险，报名需谨慎）！

 近年来研究团队发表的主要文章如下：

1.         Su Chenglin#, Yang Ruirui#, Lv Ruili, Wang Zhengjie, Zhu Jiaxuan, Zhang Xiaoxiao, Li Huimin, Luan Yushi*. The lncRNA47980-miR5303-FBA41 module affects tomato resistance to Phytophthora infestans by fine-tuning ROS and phytohormones level. Plant Physiology. 2026, https://doi.org/10.1093/plphys/kiag012. (TOP期刊)

2.         Zhu Jiaxuan, Yang Ruirui, Li Yan, Lv Ruili, Li Huimin, Yao Yao, Luan Yushi*. The Papain-Like Cysteine Proteases (PLCP) in Tomato: Identification, Expression Analysis, and Functional Characterization of SlRD19Bunder Salt Stress. Plant Science, 2026, 364: 112974.

3.         Li Yan#, Zhu Jiaxuan#, Lv Ruili, Wang Zhengjie, Li Huimin, Yang Ruirui, Luan Yushi*. Functional analysis of SlCDPK12 and its interacting protein SlACS11 in the regulation of tomato resistance to Phytophthora infestans. Journal of Plant Physiology, 2026, 317: 154689.

4.         Wang Zhicheng#, Lv Ruili#, Hong Yuhui, Su Chenglin, Wang Zhengjie, Zhu Jiaxuan, Yang Ruirui, Wang Ruiming, Li Yan, Meng Jun, Luan Yushi*. Transcription factor KUA1 positively regulates tomato resistance against Phytophthora infestans by fine-tuning reactive oxygen species accumulation. Plant Journal, 2025, 121: e70007. (TOP期刊; 高被引论文)

5.         Yang Ruirui, Su Chenglin, Xue Zhiyuan, Wei Hongbo, Wang Zhengjie, Zhu Jiaxuan, Meng Jun, Luan Yushi*. Combination of PAMP-induced peptide signalling and its regulator SpWRKY65 boosts tomato resistance to Phytophthora infestans. Plant Journal, 2025, 121: e70098. (TOP期刊)

6.         Wei Hongbo#, Yang Ruirui#, Xue Zhiyuan, Zhu Jiaxuan, Zhang Qiang, Luan Yushi*. Molecular traits of Rapid Alkalinization Factor family and functional analysis of SlRALF2 in tomato resistance to Phytophthora infestans. Journal of Agricultural and Food Chemistry. 2025, 73: 3622-3634. (TOP期刊)

7.         Xue Zhiyuan#, Yang Ruirui#, Zhu Jiaxuan, Zhang Xiaoxiao, Pu Yuqi, Luan Yushi*. Functional Characterization of Protease Inhibitor SlPinII5 in Tomato Resistance to Late Blight. Journal of Agricultural and Food Chemistry. 2025, 73, 30836-30847. (TOP期刊)

8.         Zhu Jiaxuan, Li Yan, Yang Ruirui, Xue Zhiyuan, Lv Ruili, Wei Hongbo, Wang Zhengjie, Wang Ruiming, Luan Yushi*. The receptor-like kinase SlLRR-RLK94 as a positive regulator of tomato resistance to Phytophthora infestans. Plant Cell Reports, 2025, 44: 257.

9.         Yang Ruirui#, Xue Zhiyuan#, Zhu Jiaxuan#, Lv Ruili, Li Yan, Zhang Xiaoxiao, Luan Yushi*. The plantacyanin gene family in tomato: genome-wide identification, expression analysis, and regulation of salt stress tolerance. Plant Physiology and Biochemistry, 2025, 229: 110485. (TOP期刊)

10.     Yang Ruirui#, Wei Hongbo#, Zhu Jiaxuan, Xue Zhiyuan, Zeng Siya, Meng Jun, Luan Yushi*. Characterization of PAMP‑induced peptides and mechanistic insights into SlPIP2‑mediated defense in tomato. Plant Cell Reports, 2025, 44: 149.

11.     Wang Ruiming, Wang Zhengjie, Wang Zhicheng, Su Chenglin, Zhu Jiaxuan, Lv Ruili, Yang Ruirui, Luan Yushi*. The basic helix-loop-helix (bHLH) transcription factor bHLH130 negatively regulates tomato resistance to Phytophthora infestans. International Journal of Biological Macromolecules. 2025, 311: 143908. (TOP期刊)

12.     Wang Zhengjie, Lv Ruili, Su Chenglin, Li Yan, Fang Sizhe, Yang Ruirui, Zhu Jiaxuan, Wang Ruiming, Meng Jun, Luan Yushi*. Regulatory Peptide Encoded by the Primary Transcript of miR396a Influences Gene Expression and Root Development in Solanum lycopersicum. Journal of Agricultural and Food Chemistry. 2024, 72 (29): 16390-16402. (TOP期刊)

13.     Zhou Xiaoxu#, Wang Zhengjie#, Su Chenglin, Cui Jun, Meng Jun, Luan Yushi*. Genome-wide analyses of miRNAs in mycorrhizal plants in response to late blight and elucidation of the role of miR319c in tomato resistance. Horticultural Plant Journal. 2024, 10 (6): 1371-1382. (TOP期刊)

14.     Liu Jie#, Zhu Jiaxuan#, Yang Ruirui, Su Chenglin, Wang Zhicheng, Meng Jun, Luan Yushi*. SlLTPg1, a tomato lipid transfer protein, positively regulates in response tobiotic stresses. International Journal of Biological Macromolecules. 2024, 279: 135219. (TOP期刊)

15.     Yang Ruirui, Wang Zhicheng, Zhao Lei, Liu Jie, Meng Jun, Luan Yushi*. The secreted peptide SpPIP1 modulates disease resistance and salt tolerance in tomato. Journal of Agricultural and Food Chemistry. 2023, 71 (32): 12264-12279. (TOP期刊)

16.     Su Chenglin#, Wang Zhengjie#, Cui Jun, Wang Zhicheng, Wang Ruiming, Meng Jun, Luan Yushi*. Sl-lncRNA47980, a positive regulator affects tomato resistance to Phytophthora infestans. International Journal of Biological Macromolecules. 2023, 248: 125824. (TOP期刊)

17.     Wang Zhengjie#, Cui Qi#, Su Chenglin, Zhao Siyuan, Wang Ruiming, Wang Zhicheng, Meng Jun, Luan Yushi*. Unveiling the Secrets of Non-coding RNA-encoded Peptides in Plants: A Comprehensive Review of Mining Methods and Research Progress. International Journal of Biological Macromolecules. 2023, 242: 124952. (TOP期刊)

18.     Hong Yuhui, Zhang Yuanyuan, Cui Jun, Meng Jun, Chen Yinhua, Zhang Chengwei, Yang Jinxiao* and Luan Yushi*. The lncRNA39896–miR166b–HDZs module affects tomato resistance to Phytophthora infestans. Journal of Integrative Plant Biology, 2022, 64: 1979-1993. (TOP期刊; 高被引论文).

19.     Jiang Ning#, Cui Jun#, Hou Xinxin, Yang Guanglei, Xiao Yu, Han Lu, Meng Jun*, Luan Yushi*. Sl-lncRNA15492 interacts with Sl-miR482a and affects Solanum lycopersicum immunity against Phytophthora infestans. Plant Journal, 2020. 103(4): 1561-1574. (TOP期刊)

20.     Zhou Xiaoxu, Cui Jun, Meng Jun, Luan Yushi*. Interactions and links among the noncoding RNAs in plants under stresses. Theoretical and Applied Genetics. 2020, 133(12), 3235-3248. (TOP期刊).

21.     Chen Lei, Meng Jun, He Xiaoli, Zhang Ming, Luan Yushi*. Solanum lycopersicum microRNA1916 targets multiple target genes and negatively regulates the immune response in tomato. Plant Cell and Environment. 2019, 42(4): 1393-1407. (TOP期刊)

22.     Cui Jun, Jiang Ning, Meng Jun*, Yang Guanglei, Liu Weiwei, Zhou Xiaoxu, Ma Ning, Hou Xinxin, Luan Yushi*. LncRNA33732-RESPIRATORY BURST OXIDASE module associated with WRKY1 in tomato- Phytophthora infestans interactions. Plant Journal, 2019, 97(5): 933-946. (TOP期刊; 高被引论文)

23.     Jiang Ning, Cui Jun, Shi Yunsheng, Yang Guanglei, Zhou Xiaoxu, Hou Xinxin, Meng Jun*, Luan Yushi*, Tomato lncRNA23468 functions as a competing endogenous RNA to modulate NBS-LRR genes by decoying miR482b in the tomato-Phytophthora infestans interaction. Horticulture Research. 2019, 6 :28. (TOP期刊).

24.     Cui Jun, Xu Pinsan, Meng Jun*, Li Jingbin, Jiang Ning, Luan Yushi*, Transcriptome signatures of tomato leaf induced by Phytophthora infestans and functional identification of transcription factor SpWRKY3. Theoretical and Applied Genetics. 2018, 131(4): 787-800 (TOP期刊).

25.     Jiang Ning, Meng Jun*, Cui Jun, Sun Guangxin, Luan Yushi*, Function identification of miR482b, a negative regulator during tomato resistance to Phytophthora infestans. Horticulture Research. 2018, 5 :9. (TOP期刊).

26.     Cui Jun, Luan Yushi*, Jiang Ning, Bao Hang, Meng Jun*, Comparative transcriptome analysis between resistant and susceptible tomato allows the identification of lncRNA16397 conferring resistance to Phytophthora infestans by co-expressing glutaredoxin. Plant Journal, 2017, 89(3): 577-589. (TOP期刊; 高被引论文)

27.     张晓艺(本科生)#, 洪雨慧#, 张媛媛, 栾雨时*. Sly-miR166b及其靶基因在番茄抗晚疫病中的作用初探. 园艺学报, 2021, 48 (8): 1595-1604.

授权发明专利：

栾雨时，张媛媛，洪雨慧；发明专利: 番茄抗晚疫病长链非编码RNA-lncRNA40787及其克隆方法与应用方法；专利号：ZL202010984101.2, 2023年11月24日。

栾雨时，洪雨慧，张媛媛；发明专利“番茄抗晚疫病基因Sly-miR166b及其克隆方法与应用方法”，专利号：ZL202010984073.4, 2022年2月22日。

栾雨时, 张敏. 发明专利: 番茄抗晚疫病外显子环状RNA-EcircRNA45及其克隆、检测与应用方法, 专利号：ZL 201810430303.5， 2021年9月10日。

栾雨时, 姜宁, 崔军. 发明专利: 番茄长链非编码RNA-lncRNA23468及其克隆方法与应用方法, 专利号：ZL201810057162.7, 2021年5月18日。

栾雨时, 姜宁, 崔军, 杨广磊. 发明专利：番茄抗晚疫病基因SpNBS-LRR及其克隆方法与应用方法, 专利号：ZL 201710172194.7, 2020年6月2日。

1977.09 - 1979.07

梅河口市第五高中   无   无

1994.09 - 1997.07

东北师范大学   植物学   博士

1985.09 - 1988.07

吉林农业大学   植物学   硕士

1979.09 - 1983.07

吉林农业大学   植物学   学士

1998.07 - 至今

大连理工大学   教师

1988.07 - 1998.06

吉林农业大学   教师

1983.07 - 1985.08

吉林省白山市蔬菜所   技术员

2017.10 - 至今  

中国园艺学会分子育种分会理事

2014.11 - 2022.08  

中国生物化学与分子生物学会农业分会理事

植物基因工程: 探寻、发现并克隆重要的基因；借助过表达、沉默等技术掌握基因的特性及功能；合理、有效地利用功能基因服务于农业生产和人民生活。

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植物与微生物互作: 查明有害（有益）细菌、真菌、病毒等在侵染植物过程中的作用机制，为确保植物健康、快速生长奠定基础。

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非编码RNA调控与功能: 鉴定植物非编码RNA，阐明其功能及作用机制；通过非编码RNA组学的研究，构建并完善相关调控网络；为揭示生命的奥秘添砖加瓦。