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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连理工大学
学位：硕士
所在单位：化工学院
学科：药物工程. 精细化工. 药物化学
办公地点：大连理工大学西部校区化工实验楼G段311
联系方式：mengqw@dlut.edu.cn
电子邮箱：mengqw@dlut.edu.cn
Enantioselective alpha-Benzoyloxylation of beta-Keto Esters by N-Oxide Phase-Transfer Catalysts
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论文类型：期刊论文
发表时间：2018-02-16
发表刊物：JOURNAL OF ORGANIC CHEMISTRY
收录刊物：SCIE、EI、PubMed
卷号：83
期号：4
页面范围：2263-2273
ISSN号：0022-3263
摘要：An efficient and enantioselective alpha-benzoyloxylation of beta-keto esters has been achieved by phase-transfer catalysis. This simple catalytic procedure is applicable to a range of beta-keto esters with cinchona-derived N-oxide asymmetric phase-transfer catalysts and gives the corresponding products in good enantiopurity (up to 95% ee) and yield (up to 99%). This simple and effective oxyfunctionalization is a useful synthetic strategy for introducing an oxygen-containing functional group at the a position of beta-dicarbonyl compounds.