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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连理工大学
学位：硕士
所在单位：化工学院
学科：药物工程. 精细化工. 药物化学
办公地点：大连理工大学西部校区化工实验楼G段311
联系方式：mengqw@dlut.edu.cn
电子邮箱：mengqw@dlut.edu.cn
High-efficiency alpha-benzoyloxylation and hydroxylation of beta-keto amides by phase transfer catalysis
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论文类型：期刊论文
发表时间：2018-07-26
发表刊物：TETRAHEDRON
收录刊物：SCIE
卷号：74
期号：30
页面范围：4126-4133
ISSN号：0040-4020
关键字：alpha-Benzoyloxylation; Phase-transfer catalysis; alpha-Hydroxylation; beta-keto amides; Acyloxy-functionalization
摘要：A facile and efficient protocol for alpha-benzoyloxylation and alpha-hydroxylation of beta-keto amides by phase-transfer catalysis is presented. This methodology provides mild and practical access to a variety of alpha-oxygenated beta-keto amides. Furthermore, alpha-benzoyloxylation products can be easily converted into alpha-hydroxylation compounds, which are useful synthetic precursors of biological targets. (C) 2018 Elsevier Ltd. All rights reserved.