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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连理工大学
学位：硕士
所在单位：化工学院
学科：药物工程. 精细化工. 药物化学
办公地点：大连理工大学西部校区化工实验楼G段311
联系方式：mengqw@dlut.edu.cn
电子邮箱：mengqw@dlut.edu.cn
Diterpenoid Alkaloid Lappaconine Derivative Catalyzed Asymmetric alpha-Hydroxylation of beta-Dicarbonyl Compounds with Hydrogen Peroxide
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论文类型：期刊论文
发表时间：2014-06-01
发表刊物：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
收录刊物：SCIE、Scopus
卷号：2014
期号：16
页面范围：3491-3495
ISSN号：1434-193X
关键字：Alkaloids; Asymmetric catalysis; Hydroxylation; beta-Dicarbonyl compounds; Organocatalysis
摘要：A new framework derived from the commercially available diterpenoid alkaloid lappaconitine was evaluated as a Bronsted base catalyst for the enantioselective alpha-hydroxylation of beta-dicarbonyl compounds by using 30% hydrogen peroxide as a green and highly practical source of oxygen. This protocol allows convenient access to the corresponding alpha-hydroxy-beta-oxo esters, alpha-hydroxy-beta-oxo amides and (-)-kjellmanianone with up to 98% yield and 92% ee.