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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连理工大学
学位：硕士
所在单位：化工学院
学科：药物工程. 精细化工. 药物化学
办公地点：大连理工大学西部校区化工实验楼G段311
联系方式：mengqw@dlut.edu.cn
电子邮箱：mengqw@dlut.edu.cn
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Asymmetric Direct alpha-Hydroxylation of beta-Oxo Esters Catalyzed by Chiral Quaternary Ammonium Salts Derived from Cinchona Alkaloids
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论文类型：期刊论文
发表时间：2012-11-02
发表刊物：JOURNAL OF ORGANIC CHEMISTRY
收录刊物：SCIE、EI、PubMed、Scopus
卷号：77
期号：21
页面范围：9601-9608
ISSN号：0022-3263
摘要：Cinchona alkaloid-derived chiral quaternary ammonium organocatalysts were developed. The catalyst with a bulky 1-adamantoyl group at the C-9 position promoted the enantioselective alpha-hydroxylation of beta-oxo esters and resulted in the corresponding products in 35-95% yields and 58-90% ee. The reaction was successfully scaled to a gram-quantity scale with a similar yield without loss of enantioselectivity.