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论文类型： 期刊论文

发表时间： 2017-01-25

发表刊物： TETRAHEDRON LETTERS

收录刊物： SCIE、Scopus

卷号： 58

期号： 4

页面范围： 321-325

ISSN号： 0040-4039

关键字： N-Chloramine; Chemical synthesis; Pyridinium salt; Bactericidal activity

摘要： To develop more efficacious antibacterial agents, a new type of cationic N-chloramines that contain a pyridinium moiety and a N-chloramine moiety covalently linked via an alkyl chain were prepared and characterized. Preliminary assays indicated that 1) the compound with a propylidene linker exhibited higher antibacterial activity than the quaternary ammonium counterpart; 2) the chain length of the alkyl linker had major effects on their biocidal properties. Our results may inspire exploration of more pyridinium N-chloramines for antibacterial applications. (C) 2016 Elsevier Ltd. All rights reserved.