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发布时间：2019-03-12

论文类型：期刊论文

发表时间：2017-01-25

发表刊物：TETRAHEDRON LETTERS

收录刊物：Scopus、SCIE

卷号：58

期号：4

页面范围：321-325

ISSN号：0040-4039

关键字：N-Chloramine; Chemical synthesis; Pyridinium salt; Bactericidal activity

摘要：To develop more efficacious antibacterial agents, a new type of cationic N-chloramines that contain a pyridinium moiety and a N-chloramine moiety covalently linked via an alkyl chain were prepared and characterized. Preliminary assays indicated that 1) the compound with a propylidene linker exhibited higher antibacterial activity than the quaternary ammonium counterpart; 2) the chain length of the alkyl linker had major effects on their biocidal properties. Our results may inspire exploration of more pyridinium N-chloramines for antibacterial applications. (C) 2016 Elsevier Ltd. All rights reserved.