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论文类型： 期刊论文

发表时间： 2019-10-24

发表刊物： CHEMISTRYSELECT

收录刊物： SCIE

卷号： 4

期号： 39

页面范围： 11455-11459

ISSN号： 2365-6549

关键字： Sulfobetaine N-chloramines; Chemical synthesis; Antibacterial activity

摘要： A series of sulfobetaine N-chloramines, covalently combining an N-chloramine unit and a sulfobetaine unit with varied intercharge linkers, were chemically synthesized. Preliminary antibacterial tests showed that the antibacterial activity decreased as the methylene linker increases from -(CH2)(2)- to -(CH2)(8)- except the linker of -(CH2)(6)-, which exerted remarkable bactericidal efficacy unusually. In addition, the analogue with the linker of -(CH2)(10)- displayed the highest bactericidal efficacy among all synthetic N-chloramines, probably due to its neutral zwitterionic characteristic on structure. Our research provided highly efficacious antibacterial agents together with the vital references to design novel ionic N-chloramine biocides.