Research Interests

Ø  Biomedical Optical Imaging for Retina and Eye Research

Structural and functional imaging in health and disease eyes

using Optical Coherence Tomography, Scanning Laser Ophthalmoscopy, and Adaptive Optics

Ø  Instrumentation

Design and develop customized optical imaging instruments with engineering skills (Optical, Electrical, Mechanical, Computer Programming) for biomedical research

Employment

School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology

12.2020-present       Professor

School of Medicine, University of California Davis (UCD)

07.2019-12.2020      Associate Project Scientist

06.2017-06.2019      Assistant Project Scientist

06.2013-05.2017      Postdoctoral Researcher

Department of Biomedical Engineering, National University of Singapore (NUS)

01.2012-05.2013      Postdoctoral Researcher

Education

School of Mechanical Engineering, Xi’an Jiaotong University (XJTU)

09. 2007-09.2011     Ph.D. - Instrumentation Science and Technology

09. 2004-07.2007     Master - Measuring & Testing Technology and Instrument

09. 2000-07.2004     Bachelor - Measurement & Control Technology and Instrument

Publications

 (Journal, ^#equal contribution, ^*Corresponding Author)

1.        L. Zhang, R. Dong, R.J. Zawadzki, P. Zhang^*, "Volumetric data analysis enabled spatially resolved optoretinogram to measure the functional signals in the living retina", Journal of Biophotonics, 2021.

2.        E. Pijewaka, P. Zhang, et al., "Extraction of phase-based optoretinograms (ORG) from serial B-scans acquired over tens of seconds by mouse retinal raster scanning OCT system", Biomedical Optics Express, 2021.

3.        J.B. Miesfeld, N.M. Ghiasvan, …, P. Zhang, et al., "The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell development", Proceedings of the National Academy of Sciences (PNAS), 2020.

4.        P. Zhang, T. Zhang, W. Song, Y. Lu, Y. Jian, "Review of advances in ophthalmic optical imaging technologies from several mouse retinal imaging methods", Chinese Journal of Lasers (中国激光), 2020.

5.        P. Zhang, B. Shibata, G. Peinado, et al., "Measurement of diurnal variation in rod outer segment length in vivo in mice with the OCT optoretinogram", IOVS, 2020.

6.        S.H. Chung, I.N. Mollhoff, … , P. Zhang, et al., "Factors impacting efficacy of AAV-mediated CRISPR-based genome editing for treatment of choroidal neovascularization", Molecular Therapy - Methods & Clinical Development, 2020.

7.        A. Yazdanyar, P. Zhang, C. Dolf, et al., "Effects of intravitreal injection of human CD34+ bone marrow stem cells in a murine model of diabetic retinopathy", Experimental Eye Research, 2020.

8.        P. Zhang, E.B. Miller, S. Manna, et al., "Temporal speckle-averaging of optical coherence tomography volumes for in vivo cellular resolution neuronal and vascular retinal imaging", Neurophotonics, 2019.

9.        E.B. Miller, P. Zhang, K. Ching, et al., "In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury", Proceedings of the National Academy of Sciences (PNAS), 2019.

10.     A.M. Miltner, Y. M. Ayon, S. K. Cheema, P. Zhang, et al., "A novel reporter mouse uncovers endogenous Brn3b expression", International Journal of Molecular Science, 2019.

11.     D. Wahl^#, P. Zhang^#, J. Mocci, et al., "Adaptive optics in the mouse eye: wavefront sensing based vs. image-guided aberration correction", Biomedical Optics Express, 2019.

12.     R.K. Meleppat, P. Zhang, M. Ju, et al., "Directional optical coherence tomography reveals melanin concentration dependent scattering properties of retinal pigment epithelium", Journal of Biomedical Optics, 2019.

13.     P. Zhang, S.K. Manna, E. B. Miller, et al., "Aperture phase modulation with adaptive optics: a novel approach for speckle reduction and structure extraction in optical coherence tomography", Biomedical Optics Express, 2019.

14.     M. Goswami, X. Wang, P. Zhang, et al., "Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacy in vivo", Biomedical Optics Express, 2019.

15.     P. Zhang, J. Mocci, D. Wahl, et al., "Effect of a contact lens for in vivo mouse retinal imaging: effective focal length changes and monochromatic aberrations", Experimental Eye Research, 2018.

16.     X. Wang, E.B. Miller, M. Goswami, P. Zhang, et al. "Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130", Journal of Neuroinflammation, 2017.

17.     P. Zhang, R.J. Zawadzki, M. Goswami, P.T. Nguyen, et al., "In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors". Proceedings of the National Academy of Sciences (PNAS), 2017.

18.     P. Zhang, M. Goswami, R.J. Zawadzki, et al., "The photosensitivity of rhodopsin bleaching and light-induced increases of fundus reflectance in mice measured in vivo with scanning laser ophthalmoscopy", Investigative Ophthalmology & Visual Science, 2016.

19.     E. Moisseiev, Z. Smit-McBride, S. Oltjen, P. Zhang, et al., "Intravitreal administration of human bone marrow CD34+ stem cells in a murine model of retinal degeneration intravitreal human CD34+ cells on retinal degeneration", Investigative Ophthalmology & Visual Science, 2016.

20.     P. Zhang, M. Goswami, A. Zam, et al., "Effect of scanning beam size on the lateral resolution of mouse retinal imaging with SLO", Optics letters, 2015.

21.     P. Zhang, A. Zam, Y. Jian, et al., "In vivo wide-field multispectral scanning laser ophthalmoscopy–optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature", Journal of biomedical optics, 2015.

22.     S. Bonora, Y. Jian, P. Zhang, et al.,"Wavefront correction and high-resolution in vivo OCT imaging with an objective integrated multi-actuator adaptive lens", Optics Express, 2015.

23.     R.J. Zawadzki, P. Zhang, et al., "Adaptive-optics SLO imaging combined with phase-variance OCT and widefield SLO enables precise 3D localization of fluorescent microglia", Biomedical Optics Express, 2015.

24.     E. S. Levine, A. Zam, P. Zhang, et al., "Rapid light-induced activation of retinal microglia in mice lacking Arrestin-1", Vision research, 2014.

25.     C.S. Lim, F.J. Parra-Velandia, N. Chen, P. Zhang, et al.,"Optical coherence tomography as a tool for characterization of complex biological surfaces", Journal of microscopy, 2014.

26.     P. Zhang^#, K. Mehta^#, S. Rehman, et al., "Imaging single chiral nanoparticles in turbid media using circular-polarization optical coherence microscopy", Scientific reports, 2014.

27.     P. Zhang, H. Zhao, J. Huang, et al., "Suppression of stitching edge artifacts with weighting technique", Optical Engineering, 2014.

28.     K.B. Mehta^#, P. Zhang^#, E.L. Yeo, J.C. Kah, et al., "Dark-field circular depolarization optical coherence microscopy", Biomedical Optics Express, 2013.

29.     A. Tian, S. Wu, B. Liu, P. Zhang, "Global optimization algorithm of sub-aperture stitching weight coefficients", Acta Photonica Sinica (光子学报), 42(8), 2013.

30.     S. Wu, A. Tian, B. Liu, P. Zhang, "System error correcting method in sub-aperture stitching", Journal of Applied Optics (应用光学), 2013.

31.     P. Zhang^*, H. Zhao, B. Liu, et al., "Simple method for the implementation of sub-aperture stitching interferometry", Optical Engineering, 2011.

32.     P. Zhang^*, H. Zhao, X. Zhou, et al., "Sub-aperture stitching interferometry using stereovision positioning technique", Optics Express, 2010.

33.     P. Zhang^*, H. Zhao, X. Zhou, et al., "Work-piece localization in sub-aperture stitching test based on stereo vision", Optics and Precision Engineering (光学精密工程), 2010.

34.     L. Zhang, H. Zhao, W. Dong, N. Cao, P. Zhang, "Design of an optical system consisting of a special telecentric lens for individual cells side scattering measurement", Optical Engineering, 2010.

(Selected Conference Paper)

1.        P. Zhang, D.J. Wahl, J. Mocci, et al., "Adaptive optics with combined optical coherence tomography and scanning laser ophthalmoscopy for in vivo mouse retina imaging", SPIE Photonics West, BiOS 2018.

2.        P. Zhang, Goswami M, E.N. Pugh, et al., "Fluorescent scanning laser ophthalmoscopy for cellular resolution in vivo mouse retinal imaging: benefits and drawbacks of implementing adaptive optics", SPIE Photonics West, BiOS 2016.

3.        P. Zhang, A. Zam, Y. Jian, et al., "Multispectral scanning laser ophthalmoscopy combined with optical coherence tomography for simultaneous in vivo mouse retinal imaging", SPIE Photonics West, BiOS 2015.

4.        P. Zhang, A. Zam, E.N. Pugh, et al., "Evaluation of state-of-the-art imaging systems for in vivo monitoring of retinal structure in mice: current capabilities and limitations", SPIE Photonics West, BIOS 2014.

5.        P. Zhang^*, H. Zhao, T. Jiang, et al., "New approach to workpiece localization in subaperture stitching interferometric testing", SPIE Europe Optical Metrology, 2009.

(Book Chapter)

1.        M.E. Burns, E.S. Levine, E.B. Miller, A. Zam, P. Zhang, et al. "New developments in murine imaging for assessing photoreceptor degeneration in vivo", in "Retinal degenerative diseases", Springer International Publishing, 2016.

Academic service:

ü  Associate Editor - Frontiers in Neurology | Neuro-Opthamology (SCI)

ü  Member of SPIE - The International Society for Optics and Photonics

ü  Member of ARVO - The Association for Research in Vision and Ophthalmology

ü  Member of COS - Chinese Optical Society

ü  Member of CSOE - Chinese Society for Optical Engineering

ü  Serve as reviewer for journals including the following:

²  Optics Express

²  Biomedical Optics Express

²  Optics Letters

²  IOVS

²  Light: Science & Application

²  Scientific Reports

²  Journal of Biophotonics

²  Applied Optics

²  Optical Engineering

²  Review of Scientific Instruments

²  Journal of Medical Imaging

²  Biotechniques

²  Journal of Experimental Neuroscience

²  Neurophotonics

Attended Conferences

Ø  ARVO (Orlando, Denver, Seattle, Hawaii)                                          2014-2016, 2018, 2019

Ø  SPIE Photonic West, BiOS (San Francisco)                               2014-2016, 2018-2019, 2021

Ø  Focus on Microscopy (Singapore, Netherlands)                                                  2012, 2013

Ø  SPIE Europe Optical Metrology (Munich, Germany)                                                     2009