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发布时间：2019-03-11

论文类型：会议论文

发表时间：2010-06-26

收录刊物：Scopus、CPCI-S、EI

卷号：675-677

页面范围：369-372

关键字：Hydrophilicity/hydrophobicity; Poly(dl-lactic-co-glycolic acid); Drug release; Degradation

摘要：Hydrophilic ciprofloxacin hydrochloride and hydrophobic sirolimus were used as model drugs, and poly(dl-lactic-co-glycolic acid) 50/50 (PLGA 50/50) was used as the drug carrier to investigate the effects of hydrophilicity/hydrophobicity of a drug on its release properties from PLGA films. The results showed that ciprofloxacin hydrochloride induced faster release curves than sirolimus, and it also promoted the weight loss of films, while sirolimus inhibited the weight loss of films. However, both drugs inhibited the degradation of biodegradable carrier.