点击次数：

论文类型：期刊论文

发表时间：2015-02-01

发表刊物：CHEMOSPHERE

收录刊物：PubMed、EI、SCIE

卷号：120

页面范围：592-597

ISSN号：0045-6535

关键字：Sulfonamides; Uptake; Bioconcentration; Depuration; Common carp

摘要：Sulfonamides, a class of the most commonly used antibiotics, are being increasingly released into the aquatic environment and have recently caused considerable concerns. However, knowledge on their fate and ecotoxicological effects upon aquatic organisms is not understood yet. This work investigated mainly the bioconcentration kinetics (uptake/depuration) of sulfadiazine (SDZ) and sulfamethoxazole (SMZ) in common carp (Cyprittus carpio) by exposure in different concentrations under semi-static conditions for 48 d. The uptake rate (k(1)), growth-corrected depuration rate (k(2g)), and biological half-lives (t(1/2)) of two sulfonamides in liver and muscle were determined and they were 0.135-9.84 L kg(-1) d(-1), 0.0361-0.838 d(-1), 8.3-19.2 d, respectively. With exposure concentrations increasing, the uptake rates in liver and muscle decreased obviously but the depuration rates were not closely related with the exposure concentrations. SDZ exhibited higher uptake but lower excretion rates in almost all the liver and muscle than SMZ, resulting in both higher BCFs and half-lives for SDZ. The growth-corrected bioconcentration factors (BCFkg) were measured to be 1.65-165.73 L kg(-1) ww and their averages were in good consistency with the values predicted by previous models within one log unit. The work presented here was the first to model bioconcentration of SMZ and SDZ from water by laboratory-exposed fish. (c) 2014 Elsevier Ltd. All rights reserved.