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论文类型：期刊论文

发表时间：2014-06-15

发表刊物：JOURNAL OF HAZARDOUS MATERIALS

收录刊物：Scopus、PubMed、EI、SCIE

卷号：274

页面范围：16-23

ISSN号：0304-3894

关键字：OH-PBDEs; Bioconcentration; Distribution; Common carp

摘要：Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) have attracted wide concerns due to their toxicities and universal presence in wildlife and humans. The relatively high K-ow values of OH-PBDEs imply these compounds may have a significant bioaccumulation potential, but so far, the existing data provide little information regarding the kinetics of uptake and depuration in any organisms. Here we exposed common carps separately to two OH-PBDEs, 2'-OH-BDE68 and 4-OH-BDE90, for 30 days (d) in a flow-through system, followed by a 60-d depuration period in clean water to investigate compound-specific bioaccumulation and tissue distribution. Two OH-PBDEs could accumulate in common carp, and the high concentration was observed in liver or kidney. The uptake rates (k(1)) of two OH-PBDEs ranged from 0.15 to 21.3 d(-1) in fish, and the elimination rates (k(2)) ranged from 0.027 to 0.075 d(-1), which leaded to their BCF values in 4.8-299.2 ranges. Half-lives ranged from 9.2 d to 25.6 d. The exposure concentration significantly affected BCF values but didn't change their relative compositions in liver, kidney and muscle after a long exposure time. To our knowledge, this is the first study to systematically assess uptake, depuration kinetics and tissue distribution for OH-PBDEs via a controlled experimental animal model. (C) 2014 Elsevier B.V. All rights reserved.