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任恒千，大连理工大学生物工程学院教授，2019年在美国伊利诺伊大学香槟分校化学与生物分子工程系获得博士学位；2019-2023年在美国伊利诺伊大学香槟分校卡尔乌斯基因组生物学研究所从事博士后研究；2024年5月起到大连理工大学生物工程学院工作。主要从事合成生物学工具开发及活性多肽化合物生物合成方面的研究。以第一作者身份在Nature Chemistry、Nature Communications、ACS Chemical Biology、Biotechnology and Bioengineering等国际知名学术期刊发表多篇论文。

研究方向：

主要从事活性多肽化合物生物合成方向的研究。结合生物信息学与合成生物学技术，实现天然多肽子的大规模发现、活性鉴定及合成机制解析；同时综合分子模拟、定向进化、高通量筛选等手段，促进活性多肽分子的性能优化及生物制造。

教育经历：

·         2013—2019 美国伊利诺伊大学香槟分校 化学与生物分子工程系 博士

  指导教师：Prof. Huimin Zhao

·         2009—2013 天津大学 化学工程与工艺 学士

工作经历：

·         2024-至今      教授，大连理工大学生物工程学院

·         2019—2023   博士后，美国伊利诺伊大学香槟分校 卡尔乌斯基因组生物学研究所

  合作导师：Prof. Huimin Zhao

论文成果：

1. Hengqian Ren#, Chunshuai Huang#, Yuwei Pan, Shravan R. Dommaraju, Haiyang Cui, Maolin Li, Mayuresh G. Gadgil, Douglas A. Mitchell and Huimin Zhao*. “Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides.” Nature Chemistry (2024) doi: 10.1038/s41557-024-01491-3.

2. Hengqian Ren#, Shravan R. Dommaraju#, Chunshuai Huang, Haiyang Cui, Yuwei Pan, Marko Nesic, Lingyang Zhu, David Sarlah, Douglas A. Mitchell* and Huimin Zhao*. “Genome mining unveils a class of ribosomal peptides with two amino termini.” Nature Communications 14.1 (2023): 1624.

3. Chunshuai Huang, Haiyang Cui, Hengqian Ren and Huimin Zhao*. “Genetic and computational insights into the bipentaromycin biosynthesis.” JACS Au 3.1 (2023): 195-203.

4. Richard S. Ayikpoe#, Chengyou Shi#, Alexander J. Battiste#, Sara M. Eslami, Sangeetha Ramesh, Max A. Simon, Ian R. Bothwell, Hyunji Lee, Andrew J. Rice, Hengqian Ren, Qiqi Tian, Lonnie A. Harris, Raymond Sarksian, Autumn M. Frerk, Timothy W. Precord, Wilfred A. van der Donk*, Douglas A. Mitchell* and Huimin Zhao*. “A scalable platform to discover antimicrobials of ribosomal origin.” Nature Communications 13.1 (2022): 1-15.

5. Hengqian Ren, Chengyou Shi, Ian R. Bothwell, Wilfred A. van der Donk* and Huimin Zhao*. “Discovery and characterization of a class IV lanthipeptide with a non-overlapping ring pattern.” ACS Chemical Biology 15.6 (2020): 1642-1649.

6. Hengqian Ren, Chengyou Shi and Huimin Zhao*. “Computational tools for discovering and engineering natural product biosynthetic pathways.” iScience 23.1 (2020): 100795.

7. Bin Wang#, Hengqian Ren#, Qiqi Tian and Huimin Zhao*. “Activation of silent biosynthetic gene clusters for discovery of novel natural products using synthetic biology tools.” Comprehensive Natural Products III (2020): 113-135.

8. Hengqian Ren, Subhanip Biswas, Sherri Ho, Wilfred A. van der Donk* and Huimin Zhao*. “Rapid discovery of glycocins through pathway refactoring in Escherichia coli.” ACS Chemical Biology 13.10 (2018): 2966-2972.

9. Yajie Wang#, Hengqian Ren# and Huimin Zhao*. “Expanding the boundary of biocatalysis: Design and optimization of in vitro tandem catalytic reactions for biochemical production.” Critical Reviews in Biochemistry and Molecular Biology 53.2 (2018): 115-129.

10. Hengqian Ren, Pingfan Hu and Huimin Zhao*. "A plug‐and‐play pathway refactoring workflow for natural product research in Escherichia coli and Saccharomyces cerevisiae." Biotechnology and Bioengineering 114.8 (2017): 1847-1854.

11. Hengqian Ren#, Bin Wang# and Huimin Zhao*. "Breaking the silence: New strategies for discovering novel natural products." Current Opinion in Biotechnology 48 (2017): 21-27.

12. Hengqian Ren and Huimin Zhao*. "SynV and SynX: A story more than DNA synthesis." Science China Life Sciences 60.5 (2017): 558-560.

13. Carl A. Denard, Hengqian Ren and Huimin Zhao*. "Improving and repurposing biocatalysts via directed evolution." Current Opinion in Chemical Biology 25 (2015): 55-64.

#为共同第一作者；*为通讯作者

会议报告：

1. Hengqian Ren, Chunshuai Huang, Yuwei Pan, Haiyang Cui and Huimin Zhao. “Ribosomal peptides containing fatty acyl moieties synthesized by noncannonical KASIII enzymes.” AIChE Annual Meeting, Phoenix, AZ, November 2022.

2. Hengqian Ren, Shravan R. Dommaraju, Chunshuai Huang, Haiyang Cui, Yuwei Pan, Marko Nesic, Lingyang Zhu, David Sarlah, Douglas A. Mitchell and Huimin Zhao. “Genome Mining Unveils Class of Ribosomal Peptides with Two Amino Termini.” AIChE Annual Meeting, Phoenix, AZ, November 2022

3. Hengqian Ren, Chengyou Shi, Wilfred A. van der Donk and Huimin Zhao. “Discovery and characterization of a class IV lanthipeptide with a novel ring topology.”  AIChE Annual Meeting, Orlando, FL, November 2019..4

4. Hengqian Ren, Subhanip Biswas, Sherri Ho, Wilfred A. van der Donk and Huimin Zhao. “Rapid discovery of lanthipeptides and glycocins through pathway refactoring in Escherichia coli.” AIChE Annual Meeting, Pittsburgh, PA, October 2018.

5. Hengqian Renand Huimin Zhao. “A plug-and-play pathway refactoring workflow for natural product discovery in Escherichia coli and Saccharomyces cerevisiae.” AIChE Annual Meeting, San Francisco, CA, November 2016.

学术兼职：

·         担任Frontiers in Microbiology、 Frontiers in Bioengineering and Biotechnology杂志的评审编辑·         担任ACS Synthetic Biology、Microbial Cell Factories、Biotechnology for Biofuels and Bioproducts、Journal of Applied Microbiology等10余部期刊审稿人