Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2016-04-01

Journal: HUMAN CELL

Included Journals: PubMed、SCIE

Volume: 29

Issue: 2

Page Number: 53-57

ISSN: 1749-0774

Key Words: Hematopoietic stem cells (HSCs); Ex vivo expansion; Multiparameter regulation

Abstract: Hematopoietic stem cells (HSCs) are capable to self-renew with multi-potency which generated much excitement in clinical therapy. However, the main obstacle of HSCs in clinical application was insufficient number of HSCs which were derived from either bone marrow, peripheral blood or umbilical cord blood. This review briefly discusses the indispensable utility of growth factors and cytokines, stromal cells, extracellular matrix, bionic scaffold and microenvironment aiming to control the hematopoiesis in all directions and provide a better and comprehensive understanding for in vitro expansion of hematopoietic stem cells.