Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells
Release Time:2019-03-09 Hits:
Indexed by: Journal Article
Date of Publication: 2011-02-21
Journal: ORGANIC & BIOMOLECULAR CHEMISTRY
Included Journals: Scopus、PubMed、EI、SCIE
Volume: 9
Issue: 4
Page Number: 980-983
ISSN: 1477-0520
Abstract: A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by (1)H NMR, mass spectrometry analysis and Gaussian calculations.
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