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发布时间：2019-03-13

论文类型：期刊论文

发表时间：2016-04-01

发表刊物：HUMAN CELL

收录刊物：PubMed、SCIE

卷号：29

期号：2

页面范围：53-57

ISSN号：1749-0774

关键字：Hematopoietic stem cells (HSCs); Ex vivo expansion; Multiparameter regulation

摘要：Hematopoietic stem cells (HSCs) are capable to self-renew with multi-potency which generated much excitement in clinical therapy. However, the main obstacle of HSCs in clinical application was insufficient number of HSCs which were derived from either bone marrow, peripheral blood or umbilical cord blood. This review briefly discusses the indispensable utility of growth factors and cytokines, stromal cells, extracellular matrix, bionic scaffold and microenvironment aiming to control the hematopoiesis in all directions and provide a better and comprehensive understanding for in vitro expansion of hematopoietic stem cells.