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论文类型：期刊论文

发表时间：2012-07-01

发表刊物：INTERNATIONAL JOURNAL OF BIOMATHEMATICS

收录刊物：SCIE

卷号：5

期号：4

ISSN号：1793-5245

关键字：Batch culture; specific rate of cell growth; nonlinear dynamical system; parameters identification

摘要：The bioconversion of glycerol to 1,3-propanediol is a complex bioprocess. The item of product inhibition in the equation of Specific rate of cell growth is overlapped in [L. Wang, J.X. Ye, E.M. Feng and Z.L. Xiu, An improved model for multistage simulation of glycerol fermentation in batch culture and its parameter identification, Nonlinear Anal. Hybrid Syst. 3(4) (2009) 455-462]. Therefore, in this work, the specific rate of cell growth is modified by the mechanism of multistage simulation of microbial bioconversion and the previous time-dependent model is converted to the autonomous standard form. The properties of the solutions for the nonlinear dynamic system are discussed and the identifiability of the parameters is proved. Finally the feasible optimization algorithm is constructed to find the optimal parameters for the system. Numerical result shows that the improved model with identified parameters can describe the batch culture better, compared with the previous results.