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论文类型：期刊论文

发表时间：2012-03-01

发表刊物：JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS

收录刊物：SCIE、EI

卷号：236

期号：9

页面范围：2268-2276

ISSN号：0377-0427

关键字：Batch culture; Nonlinear dynamical system; Global sensitivity analysis; Parameter identification; Gradient-based algorithm

摘要：A nonlinear dynamical system was established in our preceding work to describe the batch and continuous bioconversions of glycerol to 1,3-propanediol by Klebsiella pneumoniae. The purpose of this article is to analyze the sensitivity of kinetic parameters of the dynamical system and identify their values from experiment. A global sensitivity analysis approach is constructed by combining the local technique with the Monte Carlo method. With only those parameters of higher sensitivity as design variables, we propose a parameter identification model and solve it by a gradient-based simulated annealing algorithm. Numerical results show that our methods are feasible and efficient. (C) 2011 Elsevier B.V. All rights reserved.