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Date:2026-01-10

Links to Published Journals:https://pubs.acs.org/doi/10.1021/acsanm.2c04778

Indexed by:Journal Article

Date of Publication:2022-11-23

Journal:ACS Applied Nano Materials

Included Journals:SCI

Volume:5

Issue:12

Page Number:18965-18976

ISSN:2574-0970

Key Words:magnesium alloy, polycaprolactone, corrosion resistance, biocompatibility, antibacterial property

Abstract:cellent mechanical properties, while potential cytotoxicity with rapid degradation limits their clinical applications. Moreover, it is also important for implants to avoid inflammation caused by bacterial infections in the early stage of implantation. Therefore, copper-doped anhydrous calcium phosphate nanoparticles were fabricated by the hydrothermal method and dispersed in a dicalcium phosphate dihydrate (DCPD)/Polycaprolactone (PCL) composite coating to improve its bacteriostatic properties, corrosion resistance, and biocompatibility in this paper. The impedance of the DCPD/PCL/Cu-doped anhydrous calcium phosphate (Cu-ADCP) composite-coated sample is 1 order of magnitude higher than that of the bare magnesium alloy, and the corrosion current density decreases by 2 orders of magnitude, indicating that the composite coating incorporating nanoparticles can effectively enhance the corrosion resistance. The in vitro cell experiments show its biocompatibility with sustained growth in cellular activity and increased alkaline phosphatase activity. Most importantly, the embedded copper-doped nanoparticles significantly improve the antibacterial properties of the composite coating. Compared with the composite coating with almost no antibacterial ability, the antibacterial rate reached 96 and 98% for Escherichia coli and Staphylococcus aureus, respectively, after the nanoparticles were embedded, making them a promising choice for orthopedic applications.

DOI Number:10.1021/acsanm.2c04778

Impact Factor:5.5