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发布期刊链接：https://pubs.acs.org/doi/10.1021/acsanm.2c04778

论文类型：期刊论文

发表时间：2022-11-23

发表刊物：ACS Applied Nano Materials

收录刊物：SCI

卷号：5

期号：12

页面范围：18965-18976

ISSN号：2574-0970

关键字：magnesium alloy, polycaprolactone, corrosion resistance, biocompatibility, antibacterial property

摘要：cellent mechanical properties, while potential cytotoxicity with rapid degradation limits their clinical applications. Moreover, it is also important for implants to avoid inflammation caused by bacterial infections in the early stage of implantation. Therefore, copper-doped anhydrous calcium phosphate nanoparticles were fabricated by the hydrothermal method and dispersed in a dicalcium phosphate dihydrate (DCPD)/Polycaprolactone (PCL) composite coating to improve its bacteriostatic properties, corrosion resistance, and biocompatibility in this paper. The impedance of the DCPD/PCL/Cu-doped anhydrous calcium phosphate (Cu-ADCP) composite-coated sample is 1 order of magnitude higher than that of the bare magnesium alloy, and the corrosion current density decreases by 2 orders of magnitude, indicating that the composite coating incorporating nanoparticles can effectively enhance the corrosion resistance. The in vitro cell experiments show its biocompatibility with sustained growth in cellular activity and increased alkaline phosphatase activity. Most importantly, the embedded copper-doped nanoparticles significantly improve the antibacterial properties of the composite coating. Compared with the composite coating with almost no antibacterial ability, the antibacterial rate reached 96 and 98% for Escherichia coli and Staphylococcus aureus, respectively, after the nanoparticles were embedded, making them a promising choice for orthopedic applications.

DOI码：10.1021/acsanm.2c04778

影响因子：5.5