叶智识博士 特聘研究员 硕士和博士生导师
大连理工大学-化工与环境生命学部-张大煜学院
欢迎对相关研究领域感兴趣的博士后，博士生，硕士生，本科生以及访问学生加入本课题组。
联系邮箱：yzhsh1984@dlut.edu.cn

2017年9月-至今：大连理工大学，化工与环境生命学部-张大煜学院
2013年8月-2017年8月：美国普渡大学-博士后，导师：代明骥 教授
2010年9月-2013年7月：中科院大连化学物理研究所-博士，导师：周永贵 研究员

从事过渡金属催化和有机合成研究。在过渡金属催化的有机合成方法学、不对称催化及杂环合成等领域开展了多项创新性研究，取得了多项创新成果。在 Chem. Soc. Rev., Nat. Commun., Angew. Chem. Int. Ed., J. Am. Chem. Soc., ACS Catal., Org. Lett.等国际权威期刊上发表文章36篇，总引用次数1266次， H-因子为21 (截止2017年10月)。 获得辽宁省自然科学一等奖（第四完成人）、中国科学院院长优秀奖和浙江省优秀硕士毕业论文。

代表论文：

1. Zhishi Ye, Sarju Adhikari, Yu Xia, Mingji Dai.* Expedient Syntheses of N-Heterocycles via Intermolecular Amphoteric Diamination of Allenes. Nat. Commun. 2018, 9, 721.

2. Zhi-Shi Ye, Ran-Ning Guo, Xian-Feng Cai, Mu-Wang Chen, Lei Shi, and Yong-Gui Zhou.* Enantioselective Iridium-Catalyzed Hydrogenation of 1- and 3-Substituted Isoquinolinium Salts. Angew. Chem. Int. Ed. 2013, 52, 3685-3689.

3. Zhi-Shi Ye, Mu-Wang Chen, Qing-An Chen, Lei Shi, Ying Duan, and Yong-Gui Zhou.* Ir-Catalyzed Asymmetric Hydrogenation of Pyridinium Salts. Angew. Chem. Int. Ed. 2012, 51, 10181-10184.

4. Zhishi Ye, Guanglei Lv, Wenhui Wang, Manli Zhang, and Jiang Cheng.* Rhodium-Catalyzed Cascade Reaction: Aryl Addition/Intramolecular Esterification to Access 3-Aryl and 3-Alkenyl Phthalides. Angew. Chem. Int. Ed. 2010, 49, 3671-3674.

5. Zhishi Ye, Xinpei Cai, Jiawei Li, and Mingji Dai.* Catalytic Cyclopropanol Ring Opening for Divergent Syntheses of γ-Butyrolactones and δ-Ketoesters Containing All-Carbon Quaternary Centers. ACS Catal. 2018, 8, DOI: 10.1021/acscatal.8b00711.

6. Zhishi Ye, Kristen E. Gettys, Xingyu Shen, and Mingji Dai.* Copper-Catalyzed Cyclopropanol Ring Opening Csp3-Csp3 Cross Couplings with (Fluoro)Alkyl Halides. Org. Lett. 2015, 17, 6074-6077.

7. Zhishi Ye, Tarsis F. Brust, Val J. Watts,* and Mingji Dai.* Palladium-Catalyzed Regio- and Stereoselective γ-Arylation of Tertiary Allylic Amines: Identification of Potent Adenylyl Cyclase Inhibitors. Org. Lett. 2015, 17, 892–895.

8. Zhishi Ye, and Mingji Dai.* An Umpolung Strategy for the Synthesis of β-Aminoketones via Copper-Catalyzed Electrophilic Amination of Cyclopropanols. Org. Lett. 2015, 17, 2190–2193.

9. Yong Li†, Zhishi Ye†, Tabitha M. Bellman, Teng Chi, and Mingji Dai.* Efficient Synthesis of β-CF₃/SCF₃-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols. Org. Lett. 2015, 17, 2186–2189. (†These authors contributed equally)

10. Zhishi Ye, Wenhui Wang, Fang Luo, Shouhui Zhang, and Jiang Cheng.* Rhodium-Catalyzed ortho-Benzoxylation of sp2 C-H Bond. Org. Lett. 2009, 11, 3974-3977.

11. Zhishi Ye, Pengcheng Qian, Guanglei Lv, Fang Luo, and Jiang Cheng.* Palladium-Catalyzed Cascade Aryl Addition/Intramolecular Lactonization of Phthalaldehyde to Access 3-Aryl- and Alkenylphthalides. J. Org. Chem. 2010, 75, 6043-6045.

12. Zhishi Ye, Lei Shi,* and Yong-Gui Zhou. Asymmetric Hydrogenation of Aromatic Carbocyclic Rings and Thiophenes. Synlett 2014, 25, 928-931.

13.Zhishi Ye, Miaochang Liu, Baoda Lin, Huayue Wu, Jinchang Ding, and Jiang Cheng.* Palladium-Catalyzed Cross-Coupling Reaction of Aryl Trimethoxysilanes with Terminal Alkynes. Tetrahedron Lett. 2009, 50, 530-532.

14. Zhishi Ye, Fan Chen, Fang Luo, Wenhui Wang, Baoda Lin, Xiaofei Jia, and Jiang Cheng.* Palladium-Catalyzed Mizoroki-Heck-Type Reaction of Aryl Trimethoxysilanes. Synlett 2009, 2198-2200.

15.Zhishi Ye, Kristen E. Gettys, and Mingji Dai.* Opportunities and Challenges for Direct C–H Functionalization of Piperazines. Beilstein J. Org. Chem. 2016, 12, 702–715.

16. Qing-An Chen, Zhi-Shi Ye, Ying Duan and Yong-Gui Zhou* Homogeneous palladium-catalyzed asymmetric hydrogenation. Chem. Soc. Rev. 2013, 42, 497-511. 

17. Lei Shi, Zhi-Shi Ye, Liang-Liang Cao, Ran-Ning Guo, Yue Hu, Yong-Gui Zhou.* Enantioselective Iridium-Catalyzed Hydrogenation of 3,4-Disubstituted Isoquinolines. Angew. Chem. Int. Ed. 2012, 51, 8286-8289. 

18. Duo-Sheng Wang, Zhi-Shi Ye, Qing-An Chen and Yong-Gui Zhou,* Chang-Bin Yu, Hong-Jun Fan,* and Ying Duan. Enantioselective Partial Hydrogenation of Simple Pyrroles: A Facile Access to Chiral 1-Pyrrolines. J. Am. Chem. Soc. 2011, 133, 8866-8869. 

19. Qing-An Chen, Kai Gao, Ying Duan, Zhi-Shi Ye, Lei Shi, Yan Yang and Yong-Gui Zhou.* Dihydrophenanthridine: A New and Easily Regenerable NAD(P)H Model for Biomimetic Asymmetric Hydrogenation. J. Am. Chem. Soc. 2012, 134, 2442-2448. 

20. Tarsis F. Brust, Doungkamol Alongkronrusmee, Monica Soto-Velasquez, Tanya A. Baldwin, Zhishi Ye, Mingji Dai, Carmen W. Dessauer, Richard M. van Rijn, and Val J. Watts.* Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci. Signal. 2017, 10, 5381-5391. 

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