尹磊，药学副教授，美国亚利桑那大学药学博士后，中国药理学会药物代谢专委会青年委员，中国分析药理学委员会青年委员，中国医药生物技术协会药物分析技术分会青年委员，中国药理学会会员，通化市抗击新冠疫情及核酸检测荣誉市民，吉林省优秀青年人才。Acta Pharmaceutica Sinica B、Chemical Engineer Journal、Journal of Chromatograph A、Journal of Chromatograph B、Journal of Separation Science、Biomedicine & Pharmacotherapy、Current Analytical Chemistry等SCI杂志审稿人，主要从事小分子药物、蛋白多肽类药物、PEG修饰纳米制剂、高分子聚合物及药用辅料的精准分析及药物代谢动力学研究、非靶向及靶向性代谢组学研究、临床血药浓度监测、食品及环境农药残留分析等。熟悉小分子药物、蛋白多肽类药物、高分子聚合物的一维液相色谱串联质谱方法及二维液相色谱串联质谱方法的开发，迄今共建立了体内药物浓度分析新方法100余项，在Acta Pharmaceutica Sinica B、Trends in Analytical Chemistry、Journal of Pharmaceutical Analysis、Anal Chim Acta、Talanta、Journal of Chromatography A、Analyst、Analytical and Bioanalytical Chemistry、Drug Metab Dispos等国际主流杂志发表论文90余篇，申请发明专利5项，近十年来，主持国家自然科学基金青年基金1项，省优秀青年人才基金1项，省面上项目1项，大连市科技创新基金1项，中央高校基本科研业务费资助引进人才科研专题1项，中央高校基本科研业务费医工交叉课题1项，企业横向课题2项，参与国家自然科学基金重点项目2项，面上项目4项，国家科技重大专项1项。

作为负责人主持科技项目包括：

（1）国家自然科学基金青年基金项目：基于CID In-Quadrupole 的阿霉素及多尺度PEG化阿霉素比较药代动力学研究（编号：81603182，执行年限：2017/01-2019/12）。

（2）吉林省优秀青年人才基金项目:基于LC-SWATH技术的PEG修饰多柔比星纳米胶束体内多形态成分的精准分析（编号：20190103082JH，执行年限：2019/01-2020/12）。

（3）中央高校基本科研业务费资助引进人才科研专题：基于质谱技术的纳米制剂药代动力学研究（编号：DUT21RC(3)057，执行年限：2021/06-2022/12）。

（4）辽宁省自然基金面上项目：多柔比星智能纳米药物的多组分时空协同调控与跨尺度药代动力学研究（编号：2025-MS-023，执行年限：2025/07-2027/6）。

（5）医工交叉联合基金项目：纳米药物多组分精准分析体系的构建及应用（编号：DUT23YG228，执行年限：2023/01-2024/12）。

（6）大连市科技创新基金：基于微创干式微采样和质谱技术的49种药物的血药浓度监测试剂盒开发及其在精准医疗中的应用（编号：ZX20220749，执行年限：2022/01-2023/12）。

以主要参与人参加科技项目包括：

（1）国家自然科学基金重点项目: 药物载体递送系统体内时空命运研究（编号：82030107，执行年限2021-01至2025-12）。

（2）国家自然科学基金重点项目：桥接细胞与整体的纳米药代动力学研究（编号：81430087，执行年限：2015/01-2019/12）。

（3）国家科技重大专项：药物一致性评价关键技术与标准研究（编号：2017ZX09101001，2017/07-2020/07）。

（4）国家自然科学基金面上项目: 基于质谱新技术的PEG-PLA紫杉醇纳米胶束体内多形态成分的精准分析(编号：81872831，执行年限：2019/01-2022/12)。

（5）国家自然科学基金面上项目: 基于连续可变窗口采集技术的泊洛沙姆聚合物LC-HR-MS/MS 分析方法研究与应用(编号：81773692，执行年限：2018/01-2021/12)。

（6）国家自然科学基金面上项目: 新型硒类化合物对晚期前列腺癌的治疗作用及其分子机制的研究 (编号：81272851，执行年限：2014/01-2017/12)。

（7）国家自然科学基金面上项目：几种药物分子的晶型设计构筑及其构动关系（编号：21371024，执行年限：2013/11-2017/12）。

参与横向课题（负责分析方法开发、生物样品测试、数据处理）：

原人参二醇人体药代动力学研究；头孢替坦二钠人体药代动力学研究；落新妇苷大鼠药代动力学研究；苦碟子注射液比格犬药代动力学研究；灯盏花乙素人体药代动力学研究，异丙肌酐片人体药代动力学研究；卡前列腺素甲酯比格犬药代动力学研究；前列腺素E1比格犬药代动力学研究；抗癫痫药临床血药浓度监测液相色谱串联质谱检测试剂盒的研发；甲氨喋呤临床血药浓度监测液相色谱串联质谱检测试剂盒的研发；激素血药浓度监测液相色谱串联质谱检测试剂盒的研发；维生素A、D、E、K血药浓度监测液相色谱串联质谱检测试剂盒的研发。

代表性论文：

1.LuyaoYu, Yingxia Guo, Tonghe Liu, Yunlong Sheng, Meichen Liu, Ning Zhang, Jiye Tian, Chunpeng Feng, Meiyun Shi, Lei Yin. In vivo fate mapping of a paclitaxel-loaded polymeric micelle and its components. 2026. https://doi.org/10.1016/j.apsb.2026.02.013. 中科院1区TOP, 通讯作者

2.Tong Xin, Luyao Yu, Wenying Zhang, Yingxia Guo, Chuya Wang, Zhong Li, Jiansong You, Hongyu Xue*, Meiyun Shi*, Lei Yin*. Greenness evaluation metric for analytical methods and software. Journal of Pharmaceutical Analysis. 2025 Jul;15(7):101202.中科院1区TOP，HOT paper, ESI高被引，通讯作者

3. Lei Yin, Luyao Yu, Yingxia Guo, Chuya Wang, Yuncheng Ge, Xinyue Zheng, Ning Zhang, Jiansong You, Yong Zhang, Meiyun Shi. Green analytical chemistry metrics for evaluating the greenness of analytical procedures. Journal of Pharmaceutical Analysis. 2024, 14(11), 101013. 中科院1区TOP，ESI高被引

4. Meiyun Shi, Ning Zhang, Chunpeng Feng, Jiye Tian, Yufeng Guo, Meichen Liu, Hongyu Xue, Jiansong You, Yong Zhang, Lei Yin*. Development of a UHPLC-MS/MS assay for determination of polypropylene glycol 4 K polymers coupled with micro-solid phase extraction and selection of [M + NH₄]⁺ adduct strategy to enhance sensitivity. J. Anal. Test. 2025, 9:272–278.中科院1区TOP，通讯作者

5. Meiyun Shi, Xinyue Zheng, Ning Zhang, Yufeng Guo, Meichen Liu, Lei Yin*. Overview of sixteen green analytical chemistry metrics for evaluation of the greenness of analytical methods. TrAC Trends in Analytical Chemistry.2023,166, 117211. 中科院1区TOP, , ESI高被引，通讯作者

6. Xinyue Zhou, Jiale Liu, Jiansong You, Meiyun Shi, Lei Yin*. Application of CRISPR-Based Biosensors in Analytical Chemistry. Journal of Analysis and Testing. https://doi.org/10.1007/s41664-025-00398-3. 中科院1区TOP, 通讯作者

7. Wenhai Lin^#, Lei Yin^#, Tingting Sun, Tingting Wang, Zhigang Xie*, Jingkai Gu*, Xiabin Jing. The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines. Biomacromolecules. 2018, 19(5):1625-1634.并列一作，中科院1区TOP

发表论文：

93. Shuang Feng, Yue Deng, Ziluo Zhang, Jiye Tian, Jiarui Zhang, Jiale Liu, Xinyue Zhou, Yalin Xi, Lei Yin, Meiyun Shi. Elucidating the in vivo fate of PEG600: A rapid and oligomer-resolved analytical platform using UPC²-MS/MS with ammonium adducts. Microchemical Journal. 2026, 221, 116943. 中科院2区, 通讯作者

92. Jiye Tian, Hongwei Zheng, Yongshan Ai, Tong Xin, Zihan Tang, Hongyu Xue, Lei Yin, Meiyun Shi. Environmental suitability assessment index (ESAI): an integrated metric and software for comprehensive greenness assessment of analytical methods. Microchemical Journal. 2026, 224, 117668. 中科院2区, 通讯作者

91. Chunpeng Feng, Yufeng Guo, Yunlong Sheng, Meichen Liu, Jiale Liu, Yue Deng, Shuang Feng, Yalin Xi, Meiyun Shi, Lei Yin. Ultra-selective ultra high performance liquid chromatography-triple-stage mass spectrometry assay for quantification of pyraclostrobin in zebrafish liver tissues via multistage fragmentation to enhance sensitivity. Journal of Separation Science , 2026; 49:e70385.通讯作者

90. Xiaoyan Zhang, Shuang Feng, Ziluo Zhang, Chuya Wang, Yongshan Ai , Yalin Xi, Lei Yin, Meiyun Shi. Unraveling excretion behavior of polyethylene glycol 1000 with 13–26 subunits in rats by UHPLC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis. 2026, 272, 117353. 通讯作者

89. Meichen Liu, Yalin Yu, Yifei Jing, Yingxia Guo, Chuya Wang, Hongyu Xue, Hong Liu, Lei Yin, Meiyun Shi. Comprehensive pharmacokinetic and tissue distribution study of α, ω-dipropionic acid polyethylene glycol (PA-PEG₁₂-PA) in rats using a validated UPLC-MS/MS method. Journal of Pharmaceutical and Biomedical Analysis. 2026, 272, 117382 通讯作者

88. Yue Deng, Shuang Feng, Xiaoyan Zhang, Jiarui Zhang, Jiale Liu, Xinyue Zhou, Shimeng Fu, Yong Zhang, Lei Yin, Meiyun Shi. High-throughput and green UPCC-MS/MS assay for simultaneous quantification of 20 oligomers of PEG1K coupled with ammonium adduct and post-column infusion strategies to enhance sensitivity. Journal of Chromatography A. 2026, 1770, 466726. 中科院2区TOP, 通讯作者

87. Jiye Tian, Jiarui Zhang, Zihan Tang, Chunpeng Feng, Yue Deng, Jiale Liu, Shuang Feng, Xinyue Zhou, Lei Yin, Meiyun Shi. Unveiling polymerization-dependent pharmacokinetics and dual oxidative metabolism of polyethylene glycol 600 oligomers in rats via ultra-high-performance liquid chromatography coupled to tandem mass spectrometry. Drug Metabolism and Disposition. 2026, 54, 100244. 中科院2区, 通讯作者

86. LuyaoYu, Yingxia Guo, Tonghe Liu, Yunlong Sheng, Meichen Liu, Ning Zhang, Jiye Tian, Chunpeng Feng, Meiyun Shi, Lei Yin. In vivo fate mapping of a paclitaxel-loaded polymeric micelle and its components. 2026. https://doi.org/10.1016/j.apsb.2026.02.013. 中科院1区TOP, 通讯作者

85. Jiarui Zhang, Jiale Liu, Jintian Lai, Yue Deng, Shuang Feng, Xinyue Zhou, Meiyun Shi, Lei Yin. High‑throughput UPC²‑MS/MS for elucidating the molecular‑weight‑dependent excretion kinetics of PEG polymers with 10–17 subunits. Analytical and Bioanalytical Chemistry. https://doi.org/10.1007/s00216-026-06434-0. 中科院2区, 通讯作者

84. Xinyue Zhou, Jiale Liu, Jiansong You, Meiyun Shi, Lei Yin. Application of CRISPR-Based Biosensors in Analytical Chemistry. Journal of Analysis and Testing. https://doi.org/10.1007/s41664-025-00398-3. 中科院1区TOP, 通讯作者

83. Yufeng Guo, Yuncheng Ge, Lei Yin, Meiyun Shi, Qiang Ma. Integrating ambient ionization with miniature mass spectrometry to advance green analytical chemistry: An overview. Green Analytical Chemistry. 2025, 13, 100257.

82. Xinyue Zhou, Jiale Liu, Jiansong You, Meiyun Shi, Lei Yin. Application of CRISPR-Based Biosensors in Analytical Chemistry. Journal of Analysis and Testing

https://doi.org/10.1007/s41664-025-00398-3. 中科院1区TOP, 通讯作者

81. Yingxia Guo, Jiaxin Zhang, Runran Mei, Zihan Tang, Meichen Liu, Xixian Weng, Meiyun Shi, Lei Yin. Unraveling the plasma dynamics, oxidative metabolism and excretion behavior of M-PEG₆-OH by UPLC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis. 2025, 266, 117083. 通讯作者

80. Ning Zhang, Yingxia Guo, Yijin Wang, Luyao Yu, Chunpeng Feng, Jiye Tian, Lei Yin, Meiyun Shi. Development of a bioanalytical method for quantification of methoxy-polyethylene glycol propionic acid polymer based on ultra-high performance liquid chromatography tandem mass spectrometry technique and micro-solid phase extraction to enhance sensitivity and greenness. Journal of Chromatography A. 2025, 1757, 466163. 中科院2区TOP, 通讯作者

79. Shuang Feng, Jiarui Zhang, Jiansong You, Meiyun Shi, Lei Yin. Application of magnetic nanomaterials in sample pretreatment. Microchemical Journal, 2025, 214, 114052. 中科院2区, 通讯作者

78. Yingxia Guo, Meichen Liu, Yajie Cheng, Jiye Tian, Chunpeng Feng, Qingbin Wang, Xuan Zhao, Lei Yin. Unraveling the cytotoxicity and cellular pharmacokinetic of mPEG₅-NH₂ polymers by UHPLC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 2025, 259, 116767. 通讯作者

77. Huaqiang Li, Feifei Wu, Yuxian Ding, Guozhou Long, Lei Yin. High‑throughput quantification of butachlor by DART‑MS/MS coupled with micro‑solid‑phase extraction and dual fragmentation to enhance selectivity and sensitivity. Analytical and Bioanalytical Chemistry, 2025, 417:4605–4615. 中科院2区, 通讯作者

76. Meichen Liu, Yingxia Guo, Ziyi Niu, Yufeng Guo, Shuang Feng, Xiaoyan Zhang, Jiansong You, Lei Yin, Hongyu Xue, Meiyun Shi. Ultra-sensitive quantification of fipronil in zebrafish tissues via UPLC-MS³. Journal of Chromatography B, 2025, 1259, 124625. 通讯作者

75. Jiarui Zhang, Shuang Feng, Yalin Xi, Meiyun Shi, Lei Yin. Advances in magnetic nanomaterials for biomedical sample pretreatment: synthesis, functionalization, and applications in magnetic solid-phase extraction. Advances in Sample Preparation. 2025, 15, 100208. 中科院2区, 通讯作者

74. Luyao Yu, Meichen Liu, Ziyi Niu, Jiarui Zhang, Yue Deng, Xinyue Zhou, Jiansong You, Hongyu Xue, Lei Yin, Meiyun Shi. Unveiling polymerization degree dependent pharmacokinetics and dualmetabolic pathways of polypropylene glycol oligomers in rats via UPLC-MS/MS. Bioanalysis of monodisperse HO‑PEG₈‑OH polymers in MCF‑7 cells by UHPLC‑MS/MS coupled with μ‑SPE to improve greenness and sensitivity. Analytical and Bioanalytical Chemistry. 2025. 417:4383–4394. 中科院2区, 通讯作者

73. Chunpeng Feng, Yue Deng, Yunlong Sheng, Jiye Tian, Chuya Wang, Yalin Yu, Zihan Tang, Meiyun Shi,* Lei Yin*. Unveiling polymerization degree dependent pharmacokinetics and dualmetabolic pathways of polypropylene glycol oligomers in rats via UPLC-MS/MS. Microchemical Journal. 2025. 218, 115451. 中科院2区, 通讯作者

72.Meichen Liu, Yingxia Guo, Jinhe Liu, Zihan Tang, Yufeng Guo, Xintao Liu. Deshan Zhou, Lei Yin, Meiyun Shi. Rapid and sensitive quantitation of fipronil and its metabolites fipronil sulfone, fipronil sulfide, and fipronil desulfinyl in zebrafish tissues by UHPLC-MS/MS. Journal of Separation Science, 2025; 48:e70326. 通讯作者

71.Xiaoqian Chen, Luyao Yu, Yingxia Guo, Jiansong You, Meiyun Shi*, Yalin Xi*, Lei Yin*. High throughput analysis of vancomycin in human plasma by UHPLC-MS/MS. J Pharm Biomed Anal. 2025 Jun 15:258:116729.通讯作者

70.Di Lu, Keke Zhang, Chen Cheng, Danni Wu, Lei Yin, Quan Luo, Meiyun Shi, Honglei Ma, Xuefeng Lu.Structural basis of the bifunctionality of Marinobacter salinexigens ZYF650T glucosylglycerol phosphorylase in glucosylglycerol catabolism. J Biol Chem. 2025 Feb;301(2):108127. doi: 10.1016/j.jbc.2024.108127.

69.Yingxia Guo, Meichen Liu, Yajie Cheng, Jiye Tian, Chunpeng Feng, Qingbin Wang, Xuan Zhao*, Lei Yin*. Unraveling the cytotoxicity and cellular pharmacokinetic of mPEG5-NH2 polymers by UHPLC-MS/MS. J Pharm Biomed Anal. 2025 Jul 15:259:116767.通讯作者

68.Jiye Tian, Chunpeng Feng, Hongyu Xue, Jiansong You, Meiyun Shi*, Lei Yin*. Development of a UPLC-MS/MS assay for determination of PA-PEG8-PA polymers in rat plasma coupled with [M - H]- to enhance sensitivity. Anal Methods. 2025 Mar 27;17(13):2676-2685. doi: 10.1039/d4ay02050b.通讯作者

67. Meiyun Shi, Ning Zhang, Chunpeng Feng, Jiye Tian, Yufeng Guo, Meichen Liu, Hongyu Xue, Jiansong You, Yong Zhang, Lei Yin*. Development of a UHPLC-MS/MS assay for determination of polypropylene glycol 4 K polymers coupled with micro-solid phase extraction and selection of [M + NH₄]⁺ adduct strategy to enhance sensitivity. J. Anal. Test. 2025, 9:272–278.中科院1区TOP，通讯作者

66. Chunpeng Feng, Jiye Tian, Qisheng Fang, Yajie Cheng, Yue Deng, JiaRui Zhang, Shuang Feng, Qingbin Wang, Hecheng Wang*, Xuan Zhao*, Lei Yin*. Development and validation of a high-throughput and green ultra-performance convergence chromatography-tandem mass spectrometry assay for quantification of methoxy-polyethylene glycol propionic acid polymers. Analytical and Bioanalytical Chemistry (2025) 417:3091–3102. JCR:Q1 (CHEMISTRY, ANALYTICAL) 通讯作者，中科院分析化学2区TOP

65. Tong Xin, Luyao Yu, Wenying Zhang, Yingxia Guo, Chuya Wang, Zhong Li, Jiansong You, Hongyu Xue*, Meiyun Shi*, Lei Yin*. Greenness evaluation metric for analytical methods and software. Journal of Pharmaceutical Analysis. 2025 Jul;15(7):101202.中科院1区TOP，HOT paper, ESI高被引，通讯作者

64. Yingxia Guo, Meichen Liu, Jiye Tian, Chunpeng Feng, Qingbin Wang, Xuan Zhao, Lei Yin. Unraveling the in vivo pharmacokinetic behavior of mPEG5-NH2 polymer in rats by UHPLC-MS/MS assay. J Chromatogr B Analyt Technol Biomed Life Sci. 2025 Jan 10:1252:124460. 通讯作者

63.Yuncheng Ge, Ning Zhang, Xinyue Zheng, Luyao Yu, Yajun Liu, Hongyu Xue, Jing Zhao, Jiansong You, Meiyun Shi, Lei Yin. Ultra-high-performance liquid chromatography with tandem mass spectrometry method for cellular toxicity and pharmacokinetic study of PEG1K polymers. J Sep Sci. 2024, 47(2):e2300802. 通讯作者

62.Wenhai Lin, Lei Yin, Xin Wang, Chaonan Li, Wei Zhang, Qing Pei, Huixuan Qi, Tingting Sun, Zhigang Xie, Jingkai Gu.Quantitatively analyzing the dissociation and release of disulfide-containing organic nanoparticles. J Mater Chem B. 2024, 12(37):9289-9295.共同一作

61.Di Lu, Xinyue Zheng, Hongyu Xue, Jiansong You, Lei Yin, Meiyun Shi. Determination of acetochlor by UPLC-MS3 in cells and its application to a cellular pharmacokinetic study. Analytical Biochemistry.2024, 688, 115476. 通讯作者

60.Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin. Unraveling the cytotoxicity and cellular uptake of low, medium and high molecular weight polyethylene glycol polymers in MCF-7 cells by green UPLC-MS/MS methods.Journal of Pharmaceutical and Biomedical Analysis.2024, 238, 115868. 通讯作者

59.Yingxia Guo, Jiaxin Zhang, Chuya Wang, Meichen Liu, Jiansong You, Lei Yin, Meiyun Shi. Green pretreatment of lignocellulosic biomasses via deep eutectic solvents. Sustainable Chemistry and Pharmacy. 2024, 39, 101569. 中科院2区, 通讯作者

58.Luyao Yu, Xiaoqian Chen, Yingxia Guo, Jiansong You, Meiyun Shi, Yalin Xi, Lei Yin. Quantification of tricyclic glycopeptide in human plasma by UHPLC-MS3 coupled with counter-extraction follow by protein precipitation to enhance sensitivity. Journal of Chromatography B.2024, 1247, 124343. 通讯作者

57.Lei Yin, Luyao Yu, Yingxia Guo, Chuya Wang, Yuncheng Ge, Xinyue Zheng, Ning Zhang, Jiansong You, Yong Zhang, Meiyun Shi.Green analytical chemistry metrics for evaluating the greenness of analytical procedures. Journal of Pharmaceutical Analysis. 2024, 14(11), 101013. 中科院1区TOP, ESI高被引

56. Meiyun Shi, Xinyue Zheng, Ning Zhang, Yufeng Guo, Meichen Liu, Lei Yin. Overview of sixteen green analytical chemistry metrics for evaluation of the greenness of analytical methods. TrAC Trends in Analytical Chemistry.2023,166, 117211. 中科院1区TOP, ESI高被引，通讯作者

55.Meiyun Shi, Xinyue Zheng, Hui Jiang, Yuncheng Ge, Ning Zhang, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin. Unraveling the in vivo biological fate of mPEG2000-PDLLA2500-COOH diblock copolymers by LC-MS/MS based on CID in source technique. Anal Chim Acta. 2023, 1267:341375.  JCR Q1 (CHEMISTRY, ANALYTICAL), 中科院2区TOP, 通讯作者

54. Meiyun Shi#, Lei Yin#, Yantong Sun, Can Wang, Lanlan Cai, Tinglan Zhang, Xiaotong Zhou, J Paul Fawcett, Xiaoli Gao, Jingkai Gu. Pharmacokinetic Study of Conjugated Equine Estrogens in Healthy Chinese Postmenopausal Women Using a Parallel Two-Column LC-MS/MS Method. Clin Pharmacokinet. 2022 Nov;61(11):1571-1583. JCR:Q1（PHARMACOLOGY & PHARMACY）并列一作,中科院药学1区TOP

53.Lei Yin, Tianming Ren, Shiying Zhao, Meiyun Shi, Jingkai Gu. Comparative pharmacokinetic study of PEGylated gemcitabine and gemcitabine in rats by LC-MS/MS coupled with pre-column derivatization and MSALL technique. Talanta. 2020,01;206:120184. SCI：000488416200009, JCR:Q1（CHEMISTRY, ANALYTICAL）, 中科院2区TOP

52.Wenhai Lin#, Lei Yin#, Tingting Sun, Tingting Wang, Zhigang Xie*, Jingkai Gu*, Xiabin Jing. The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines. Biomacromolecules. 2018, 19(5):1625-1634. SCI：000432476800025, JCR:Q1（CHEMISTRY）, Q1（POLYMER SCIENCE）并列一作，中科院高分子科学1区

51. Meiyun Shi, Qiuhong Jiang, Di Lu, Xinyue Zheng, Xujian Duan, Xiangyi Xu, Yajun Liu, Hongyu Xue, Lei Yin. Quantitative analysis of polypropylene glycol polymers by liquid chromatography tandem mass spectrometry based on collision induced dissociation technique. J Chromatogr A. 2022, 1676:463214. JCR:Q1（CHEMISTRY, ANALYTICAL）通讯作者，中科院分析化学2区TOP

50. Xiangyi Xu, Xuanxi Jiang, Meiyun Shi, Lei Yin. Mass spectrometry-based techniques for single-cell analysis. Analyst. 2023, 148(16):3690-3707. 中科院分析化学2区，通讯作者

49. Lei Yin, Aiyun Xu, Yumeng Zhao, Jingkai Gu. Bioanalytical assays for pharmacokinetic and biodistribution study of Antibody-Drug Conjugates. Drug Metab Dispos, 2023, 51(10):1324-1331.中科院药学2区

48. Lei Yin, Zhi Zhang, Yingze Liu, Yin Gao, Jingkai Gu. Recent advances in single-cell analysis by mass spectrometry. Analyst. 2019,02;144(3):824-845. SCI：000457394400007,  JCR:Q1（CHEMISTRY, ANALYTICAL）中科院分析化学2区

47. Meiyun Shi, Xujian Duan, Xinyue Zheng, Di Lu, Yuncheng Ge, Ning Zhang, Yajun Liu, Jiansong You, Hongyu Xue, Lei Yin. Quantification of human serum albumin by combining chymotrypsin/trypsin digestion coupled with LC-MS/MS technique. Analytical Biochemistry. 2023, 680:115316. 通讯作者

46. Xujian Duan, Di Lu, Xinyue Zheng, Qiuhong Jiang, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin, Meiyun Shi. Development and validation of an LC-MS/MS assay with multiple stage fragmentation for the quantification of alachlor in McF-7 cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2023, 1214:123550. 并列通讯作者

45. Xinyue Zheng, Xujian Duan, Di Lu, Qiuhong Jiang, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin, Meiyun Shi. Cellular toxicity and pharmacokinetic study of butachlor by ultra-performance liquid chromatography-tandem mass spectrometry based on tandem mass spectrometry cubed technique. J Sep Sci. 2023 Jan;46(1):e2200725.通讯作者. 

44. 崔雨琪#，雷芳彬#，张霖茜，尤建嵩，尹磊，史美云。聚合物纳米药物制剂生物分析方法及药动学研究进展. 药学学报, Acta Pharmaceutica Sinica 2023, 58(4): 844−851. 通讯作者

43. 刘一#，张煜杰#，王梓榆，尤建嵩，尹磊，史美云。脂质体纳米药物制剂的生物分析方法及药代动力学研究进展，药学学报，Acta Pharmaceutica Sinica 2023, 58(4): 834−843. 通讯作者

42. Yin Lei, Su Chong, Ren Tianming, Meng Xiangjun, Shi Meiyun, Paul Fawcett J, Zhang Mengliang, Hu Wei, Gu Jingkai*. MSAll strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra. Analyst. 2017,11, 142(22):4279-4288. SCI：000414485800012,  JCR:Q1（CHEMISTRY, ANALYTICAL）中科院分析化学2区

41. Meiyun Shi, Qiuhong Jiang, Qiushi Lyu, Zhengting Yuan, Lili Deng, Lei Yin. A LC-MS3 strategy to determine lamotrigine by Q-Q-trap tandem mass spectrometry coupled with triple stage fragmentation to enhance sensitivity and selectivity. Anal Methods. 2021 Oct 8;13(38):4478-4484.通讯作者

40. Lei Yin, Junfeng Yang, Xiangjun Meng, Bo Yang, Chong Su, Zhichao Yang, Mi Zheng, Limei Zhao, Jingkai Gu* and Guijie Xin*, An LC-MS/MS method to determine PABA and DIP, Analytical Methods, 2016,01; 8, 1013-1020. 

39. Meiyun Shi, Xinyue Zheng, Di Lu, Xujian Duan, Yongqi Wang, Yajun Liu, Hongyu Xue, Lei Yin. Ultrafast and high-throughput quantitative analysis of carbamazepine in human plasma by direct analysis in real time tandem mass spectrometry coupled with solid phase extraction to eliminate matrix effects. J Pharm Biomed Anal. 2022 May 30;214:114751.  通讯作者

38. Wenbo Ren#, Lei Yin#, Gaixia Zhang, Taiyu Zhai, Jing Huang. Comparison of LC-MS3 and LC-MRM Method for quantifying voriconazole and its application in therapeutic drug monitoring of human plasma. Molecules. 2022 Aug 31;27(17):5609. JCR Q2（CHEMISTRY, MULTIDISCIPLINARY）中科院化学2区, 并列一作

37. Lei Yin, Yiling Pang, Lin Shan, Jingkai Gu. The in vivo pharmacokinetics of block copolymers containing polyethylene glycol used in nanocarrier drug delivery systems. Drug Metab Dispos. 2022, 50(6):827-836.中科院药学2区

36. Lei Yin, Zhengchao Ji, Haiwei Cao, Yanyan Li, Jing Huang. Comparison of LC-MS3 and LC-MRM strategy for quantification of methotrexate in human plasma and its application in therapeutic drug monitoring. J Pharm Biomed Anal. 2021 Oct 25;205:114345. 中科院分析化学2区

35. Dongxiao Ma, Zhengchao Ji, Haiwei Cao, Jing Huang, Lei Zeng, Lei Yin. LC-MS3 Strategy for Quantification of Carbamazepine in Human Plasma and Its Application in Therapeutic Drug Monitoring. Molecules. 2022 Feb 11;27(4):1224.  中科院化学2区, 通讯作者

34. Zhengchao Ji#, Lei Yin#, Yanyan Li, Xiaoquan Yang, Lin Lin, Lingling Liu, Yi Jiang, Jing Huang. Development and validation of a liquid chromatography-tandem mass spectrometry method with triple-stage fragmentation to determine levetiracetam in epileptic patient serum and its application in therapeutic drug monitoring. J Sep Sci. 2021 Dec;44(23):4255-4263.并列一作. 

33. Haiwei Cao#, Lei Yin#, Haihuan Cao, Haiyang Guo, Wenbo Ren, Yanyan Li, Jing Huang. A sensitive and selective HPLC-MS3 method for therapeutic drug monitoring of meropenem and its validation by comparison with HPLC-MS2 methods. J Sep Sci. 2022 May;45(10):1683-1692.并列一作. 

32. Lei Yin, Yixuan Feng, Jin Tong, Zhiqiong Guo, Yuyao Zhang, Qi Zhang, Yantong Sun, Fawcett JP, Jingkai Gu. Ultrahigh-throughput absolute quantitative analysis of linezolid in human plasma by direct analysis in real time mass spectrometry without chromatographic separation and its application to a pharmacokinetic study. Anal Bioanal Chem. 2019,08;411(20):5139-5148. SCI：000475515600013,中科院分析化学2区

31. Lei Yin, Meiyun Shi, Tingting Wang, Miaomin Zhang, Xiaojun Zhao, Ying Zhang, Jingkai Gu*, A Parallel-Column LC–MS/MS Method for High-Throughput Analysis of Eight Antiepileptic Drugs in Clinical Therapeutic Drug Monitoring, Chromatographia, 2017,01,137-143. 

30. Lei Yin#, Tingting Wang#,Meiyun Shi#,Ying Zhang,Xiaojun Zhao,Yan Yang*, Jingkai Gu*, Simultaneous determination of ten antiepileptic drugs in human plasma by liquid chromatography and tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in therapeutic drug monitoring, J. Sep. Sci. 2016,03;39(5):964-72. 

29. Lei Yin, Xiangjun Meng, Xiaotong Zhou, Tinglan Zhang, Heping Sun, Zhichao Yang，Bo Yang, Ning Xiao, J. Paul Fawcett, Yan Yang, Jingkai Gu*, Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography–tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study, Journal of Chromatography B, 2015.08; 998, 8–14. SCI：000359957100002

28. Lei Yin, Meiyun Shi,Yantong Sun, Xiaocheng Sun, Huan Meng, J.Paul Fawcett, Yan Yang*, Jingkai Gua*. A liquid chromatography–tandem mass spectrometric method for the simultaneous quantitation of five components of Ixeris sonchifoliain (Bge.) Hance in rat plasma and its application to a pharmacokinetic study. Journal of Chromatography B, 2013,06; 931,12–16. SCI：000321593900003

27. Lei Yin, Yun-hui Zhang, Sen Zhao, Long-mei Cheng, Mei-yun Shi, Yan Yang*, Yan-tong Sun*, Xi-dong Liu, J.Paul Fawcett. Rapid quantification of astilbin in rat plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. Chemical Research in Chinese Universities. 2013,12; 29,1078-1082. SCI：000329095200012

26. Shi Meiyun, Zhao Xiaojun, Wang Tingting, Yin Lei, Li Yanyan. A LC-MS-MS assay for simultaneous determination of two glycopeptides and two small molecule compounds in human plasma. J Chromatogr Sci. 2018, 10; 1;56(9):828-834. 通讯作者.

25. Meiyun Shi, Mengyao Xu, Lei Yin*, Pharmacokinetic, bioavailability and tissue distribution study of astilbin in rats. J Pharm Pharmacol. 2020 Aug;72(8):1061-1071. 通讯作者. 

24. Shi M, Jiang H, Yin L, Liu Y, Xu M. Development of an UPLC-MS/MS method coupled with in-source CID for quantitative analysis of PEG-PLA copolymer and its application to a pharmacokinetic study in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Sep 1;1125:121716. 

23. Wang T, Yin L, Wang H, Fawcett JP, Gu J. Development and application of a high-throughput liquid chromatography-tandem mass spectrometric method for the simultaneous determination of thymosin α1 and its recombinant human form in plasma and urine. J Pharm Biomed Anal. 2019, 170:16-21. 

22. Xiaojiao Li, Yantong Sun, Lei Yin, Xueju Zhang, YanYang, J. paul Fawcettc, Yimin Cui, and Jingkai Gu. Quantitation of bivalirudin, a novel anticoagulant peptide, in human plasma by LC-MS/MS: method development, validation and application to pharmacokinetics. Journal of Pharmaceutical Analysis, 2013, 3(1):1-8. 中科院药学1区TOP

21. Yunhui Zhang, Yantong Sun, Guoqing Li, Lei Yin, et al. Determination of Prostaglandin E1 in dog plasma using liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. Journal of Chromatography B, 2013, 937:97–102. 

20. Xiangyong Cui, Mengliang Zhang , Xin Guan, Lei Yin, Yantong Sun, J. Paul Fawcett , Jingkai Gu. LC–MS–MS determination of troxerutin in plasma and its application to a pharmacokinetic study. Chromatographia , 2011, 73:165–169. 

19. Su Chong, Sun Hui, Yang Hong, Yin Lei, Zhang Jiwen, Fawcett JP, Gu Jingkai. A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study. Anal Bioanal Chem. 2017, 409(28):6559-6565. 中科院分析化学2区

18. Lu Huan, Su Chong, Yin Lei, Gu Liqiang, Gu Jingkai, Chen Xiaohui. Liquid chromatography-tandem mass spectrometry method for simultaneous determination of valproic acid and its ene-metabolites in epilepsy patient plasma. Journal of Pharmaceutical Analysis, 2016, 6(2):112-116.中科院药学1区TOP

17. Chen H, Zhang Q, Li X, Zhang H, Sun Y, Yin L, Liu C, Cao Y, Gu J, Ding Y. Single and multiple-dose pharmacokinetics and tolerability of limaprost in healthy Chinese subjects. Clin Drug Investig. 2015, 35(3):151-7. 

16. Feng B, Zhu H, Guan J, Zhao L, Gu J, Yin L, Fawcett JP, Liu W. A rapid and sensitive UFLC-MS/MS method for the simultaneous determination of gentiopicroside and swertiamarin in rat plasma and its application in pharmacokinetics. J Pharm Pharmacol. 2014, 66(10):1369-76.

15. Shi Meiyun, Lei Yin, CAI Lanlan, WANG Can，LIU Xidong，ZHAO Sen，SUN Yantong，FAWCETT J. Paul，ZHAO Limei，YANG Yan(*)，GU Jingkai(*)，LC-MS/MS Method for the Quantitation of Cefotetan in Human Plasma and Its Application to Pharmacokinetic Study，Chemical Research in Chinese Universities, 2014, 30(6):900-904.

14.姜翠,吴瑞红,王晓美,尹磊,尹沛源,迟秀梅,顾景凯,潘煜,许国旺.丙型肝炎自发清除者的血清代谢组学研究. 中华传染病杂志，2013, 31(2)：32-37

13. 张荣，顾景凯，尹磊，陈灵，王朝霞HPLC-MS/MS法检测吉林省427例儿童血浆25(OH)D的水平[J]. 中国妇幼保健，2013,28(2),320-322.

12. LC-Triple TOFTM 快速筛查血浆样本中2500种毒物药物。2012，第十届全国药物与化学异物代谢学术会议暨第三届ISSX/CSSX联合学术会议青年论坛优秀论文。

11. 液相色谱高分辨率质谱法快速鉴定大鼠体内川丁特罗的代谢产物. 2012，第十届全国药物与化学异物代谢学术会议。

10. 黄芩素及其四种主要代谢产物人体药代动力学分析方法研究. 第十届全国药物与化学异物代谢学术会议。

9. Yang C, Song W, Zhang D, Yu H, Yin L, Shen N, Deng M, Tang Z, Gu J, Chen X. Poly (l-glutamic acid)-g-methoxy poly (ethylene glycol)-gemcitabine conjugate improves the anticancer efficacy of gemcitabine. Int J Pharm. 2018 Oct 25;550(1-2):79-88. 2018 Aug 20. JCR: Q1 (PHARMACOLOGY & PHARMACY).

8. Liang C, Sun H, Meng X, Yin L, Fawcett JP, Yu H, Liu T, Gu J. Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry. Acta Pharm Sin B. 2018, 8(2):228-234. 中科院药学1区TOP.

7. Wang D, Li W, Zou Q, Yin L, Du Y, Gu J, Suo J. Serum metabolomic profiling of human gastric cancer and its relationship with the prognosis. Oncotarget. 2017 Sep 28;8(66):110000-110015. 

6. Daguang Wang, Wei Li, Lei Yin, Yechao Du, Shaopeng Zhang, Jian Suo. Association of serum levels of deoxyribose-1-phosphate and S-lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study. ONCOLOGY LETTERS 19: 2231-2242, 2020.

5. Xin Guan, Lei Yin, Yan Yang, Xiang-Jun Meng, De-Li Wang, Yan-Tong Sun. Quantitation of lovastatin and its hydroxy acid in human plasma by high-performance liquid chromatography-tandem mass spectrometry, Journal of Liquid Chromatography & Related Technologies,2018, 41:10, 668-675.

4. Zhi Zhang, Yuyao Zhang, Shiwen Song, Lei Yin, Dong Sun, Jingkai Gu. Recent advances in the bioanalytical methods of polyethylene glycols and pegylated pharmaceuticals, J Sep Sci. 2020 Feb 20. 

3. Leonardi A, Kovalchuk N, Yin L, Endres L, Evke S, Nevins S, Martin S, Dedon PC, Melendez JA, Van Winkle L, Zhang QY, Ding X, Begley TJ. The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene. Epigenetics. 2020 Apr 17:1-18. 

2. Man Yang, Chenyao Li, Yajing Li, Chen Cheng, Meiyun Shi, Lei Yin, Hongyu Xue, Yajun Liu. Design, synthesis, biological evaluation and molecular docking study of 2,4-diarylimidazoles and 2,4-bis(benzyloxy)-5-arylpyrimidines as novel HSP90 N-terminal inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2551-2565. 

1. Jacklyn Kelty, Nataliia Kovalchuk, Eric Uwimana, Lei Yin, Xinxin Ding , Laura Van Winkle. In vitro airway models from mice, rhesus macaques, and humans maintain species differences in xenobiotic metabolism and cellular responses to naphthalene. Am J Physiol Lung Cell Mol Physiol. 2022 Sep 1;323(3):L308-L328. JCR: Q1(PHYSIOLOGY).

申请专利具体如下：

1. 一种生物样本中PEG 化药物的定量测定方法,（ZL 201610031386.1）

2. 一种生物样本中PEG 含量的测定方法,（ZL 201510356323.9）

3. 一种PEG及PEG化药物的分析检测方法及其应用（ZL 201710706546.2）