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个人信息Personal Information
副教授
博士生导师
硕士生导师
性别：男
毕业院校：中国协和医科大学
学位：博士
所在单位：生物工程学院
学科：生物化工. 微生物学. 微生物与生化药学
办公地点：辽宁省大连市高新园区凌工路2号大连理工大学西部校区生物工程学院309室
联系方式：辽宁省大连市高新园区凌工路2号大连理工大学生物工程学院
电子邮箱：yshdong@dlut.edu.cn
Production of polyketides with anthelmintic activity by the fungus Talaromyces wortmannii using one strain-many compounds (OSMAC) method
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论文类型：期刊论文
发表时间：2016-12-01
发表刊物：PHYTOCHEMISTRY LETTERS
收录刊物：SCIE、Scopus
卷号：18
页面范围：157-161
ISSN号：1874-3900
关键字：Talaromyces wortmannii; Polyketides; OSMAC; Absolute configuration; Anthelmintic activity; NADH-fumarate reductase inhibitor
摘要：Three new polyketides, wortmannilactones I1-I3, were purified from Talaromyces wortmannii using the One Strain Many Compounds (OSMAC) strategy. The polyketides' structures were established using IR, 1D and 2D NMR, and HRESIMS analyses and the absolute configurations were identified by comparison of experimental and calculated ECDs. These polyketides exhibit selective inhibitory activity against NADH-fumarate reductase. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
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