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个人信息Personal Information
副教授
博士生导师
硕士生导师
性别：男
毕业院校：中国协和医科大学
学位：博士
所在单位：生物工程学院
学科：生物化工. 微生物学. 微生物与生化药学
办公地点：辽宁省大连市高新园区凌工路2号大连理工大学西部校区生物工程学院309室
联系方式：辽宁省大连市高新园区凌工路2号大连理工大学生物工程学院
电子邮箱：yshdong@dlut.edu.cn
Wortmannilactones I-L, new NADH-fumarate reductase inhibitors, induced by adding suberoylanilide hydroxamic acid to the culture medium of Talaromyces wortmannii
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论文类型：期刊论文
发表时间：2016-11-01
发表刊物：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
收录刊物：SCIE、PubMed、Scopus
卷号：26
期号：21
页面范围：5328-5333
ISSN号：0960-894X
关键字：Wortmannilactones; Talaromyces wortmannii; Epigenome manipulation; Suberoylanilide hydroxamic acid; NADH-fumarate reductase
摘要：With the aim of finding more potential inhibitors against NADH-fumarate reductase (specific target for treating helminthiasis and cancer) from natural resources, Talaromyces wortmannii was treated with the epigenome regulatory agent suberoylanilide hydroxamic acid, which resulted in the isolation of four new wortmannilactones derivatives (wortmannilactones 1-L, 1-4). The structures of these new compounds were elucidated based on IR, HRESIMS and NMR spectroscopic data analyses. These four new compounds showed potent inhibitory activity against NADH-fumarate reductase with the IC50 values ranging from 0.84 to 1.35 mu M. (C) 2016 Elsevier Ltd. All rights reserved.