点击次数：

论文类型：期刊论文

发表时间：2019-05-23

发表刊物：Molecular informatics

收录刊物：PubMed

ISSN号：1868-1751

关键字：PPI network analysis,apoptosis,autophagy,bi-functional proteins

摘要：Although autophagy and apoptosis, two main kinds of programmed cell death, constitute distinct cellular processes with often opposing outcomes, there have been shown a complex interplay between them in recent years. This interplay is surely critical to the overall fate of the cell. However, a full-scale identification of those bi-functional proteins involved in both functions is currently beyond reach by existing databases or traditional biological experiments. And that makes the interplay impossible to be well understood. Here we built a large, comprehensiveness apoptosis and autophagy related PPI (protein-protein interaction) network and then used topology clustering to undergo a network analysis workflow. Finally, we concluded a list of 151 apoptosis and autophagy bi-functional proteins from this network. By this way we showed a global view on these bi-functional proteins about their unique characteristics and provided clues of new functions of some proteins which are not focused in present researches.© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.