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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：医学部
学科：化学生物学. 药理学. 细胞生物学
办公地点：Chemical complex building,D513
联系方式：zczhang@dlut.edu.cn 13942696903
电子邮箱：zczhang@dlut.edu.cn
The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells
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论文类型：期刊论文
发表时间：2012-10-28
发表刊物：CANCER LETTERS
收录刊物：SCIE、Scopus
卷号：323
期号：2
页面范围：180-187
ISSN号：0304-3835
关键字：Autophagy; ER stress; BH3 mimetic; Bcl-2
摘要：Previous results showed that a novel BH3 mimetic S1 could induce cell death in a wide range of cancer types in vitro through Bax/Bak-dependent apoptosis. We demonstrated that in addition to mitochondrial pathway apoptosis, endoplasmic reticulum (ER) stress-associated apoptosis was also induced by Si. Moreover, S1 can induce autophagy in U251 cells, which may occur through ER stress and disruption of the association of Bcl-2 and Beclin 1. Inhibition of autophagy by the autophagic inhibitors 3-methyladenine (3-MA) or chloroquine (CQ) increased S1-induced apoptosis. In conclusion, autophagy plays an important role in S1-induced U251 cell death. (c) 2012 Elsevier Ireland Ltd. All rights reserved.