博士，副教授，硕士生导师、博士生导师。2012年本科毕业于哈尔滨工业大学生物技术专业，指导教师为市政学院王爱杰教授；2013年硕士毕业于香港科技大学化学工程及生物分子工程学专业，指导教师为余宝乐（Po-Lock YUE）教授；2017年博士毕业于京都大学环境工程专业，指导教师为田中宏明（Hiroaki TANAKA）教授和井原贤（Masaru IHARA）助理教授（现高知大学教授）。2017年10月至2020年6月在京都大学流域圈综合环境质量研究中心做博士后。研究方向为环境毒理与健康，围绕生物体内高度保守的膜蛋白（G蛋白偶联受体、转运蛋白、离子通道等）开展以下工作：

(1) 通过计算模拟研究新污染物对膜蛋白的识别和毒理机制。

(2) 基于机器学习，发展靶向膜蛋白的新污染物高通量毒性预测方法；开发膜蛋白的体外毒性测试技术，筛查环境中靶向膜蛋白的新污染物。

(3) 结合体外实验、模型和化学分析，基于生物效应评价化学品环境风险，筛选环境中高风险的新污染物。

(4) 研究化学品对人体慢性疾病(代谢性疾病等)的影响。

论文发表：

1. Han Zhang, Masaru Ihara*, Seiya Hanamoto, Norihide Nakada, Monika D. Jürgens, Andrew C. Johnson, Hiroaki Tanaka*. Quantification of pharmaceutical related biological activity in effluents from wastewater treatment plants in UK and Japan. Environmental Science & Technology, 2018, 52, 20, 11848-11856.

2. Han Zhang, Mariko O. Ihara, Norihide Nakada, Hiroaki Tanaka, Masaru Ihara*. Biological activity-based prioritization of pharmaceuticals in wastewater for Environmental monitoring: G Protein-Coupled Receptor Inhibitors. Environmental Science & Technology, 2020, 54, 1720-1729.

3. Han Zhang, Daisuke Kato, Mariko O. Ihara, Monika D. Jürgens, Andrew C. Johnson, Jingwen Chen, Hiroaki Tanaka, Masaru Ihara*. Biological-activity-based prioritization of antidepressants in wastewater in England and Japan. Environmental Science & Technology, 2023, 57, 6444-6454.

4. Han Zhang, Mingyuan Cao, Mariko O. Ihara, Monika D. Jürgens, Andrew C. Johnson, Jingwen Chen, Hiroaki Tanaka, Masaru Ihara*. Using zebrafish G protein-coupled receptors to obtain a better appreciation of the impact of pharmaceuticals in wastewater to fish. Environmental Science & Technology, 2025, 59, 92-102.

5. Han Zhang, Masaru Ihara*, Jingwen Chen*. Membrane proteins: Targets that should not be overlooked for assessing human and ecological health effects of chemicals. Environmental Science & Technology, 2025, 59, 16830-16838.

6. Yuan Chen, Mingyuan Cao, Yongliang Yang, Han Zhang*, Jingwen Chen*. Zebrafish serotonin transporter inhibition enables identification of neuroactive chemicals: Structural insights into interspecies differences. Environmental Science & Technology, 2026, 60, 23162-23169.

7. Guangxia Yang#, Xiang Liu#, Ruipeng Liu, Ying Liang, Xin He, Xiaochen Xu, Han Zhang*, and Jingwen Chen*. Integrating biological activity with the fish plasma model to prioritize antidepressants of concern in wastewater: A case study in Dalian, China. Environmental Science & Technology, 2026, 60, 23901-23910.