张子杰，教授，博士生导师，国家海外高层次青年人才，中国分析测试协会委员。长期从事功能核酸、生物传感、环境监测研究，致力于病原微生物即时检测POCT、小分子新污染物识别监测、以及医工融合等领域。相关成果论文发表在Journal of the American Chemical Society, Angewandte Chemie International Edition, Nano Letters, Nucleic Acids Research等期刊，主持国家自然科学基金、国家重点研发计划等项目。

课题组目前有博士后、博士和硕士生名额，欢迎有学科交叉背景同学加入（包括不限于化学、生物医学、材料、微生物、计算机AI、仪器制造等），团队活跃，待遇优厚，联系zhangzijie@dlut.edu.cn。

工作经历：

2023 - 至今  大连理工大学，环境学院，教授

2019 - 2023  加拿大麦克马斯特大学，生物医学系，博士后（导师：李应福）

2015 - 2019  加拿大滑铁卢大学，化学系，博士（导师：刘珏文）

研究方向：

(1) 核酸分子识别

(2) 生物传感技术

(3) 环境分析监测

代表论文：

27. X. Li, W. Xue, S. Xiao, Z. Li, J. Zhao, R. Zhang, J. Li, Z. Zhang*, Y. Chang*, M. Liu*, Converting One In Vitro Selected DNA Molecule Into Two Bacteria-Responsive DNAzymes by Regulation of Reaction Conditions, Angewandte Chemie International Edition 2026, e7611103, https://doi.org/10.1002/anie.7611103.

26. Z. Zhang*; W. Tian; J. Gu; J. Li; M. Liu; L. Soleymani*; Y. Li*. A general strategy to enhance aptamer affinity by suppressing dissociation through symmetric assembly. Nucleic Acids Research 2026, 54(6), gkag268.

25. Y. Fan; R. Jiang; H. Liu; W. Tian; M. Liu*; Z. Zhang*. Aptamer-and DNAzyme-based biosensors for pathogen detection: diagnostic strategies and clinical applications. Sensors & Diagnostics 2026. https://doi.org/10.1039/D6SD00023A.

24. J. Wu, S. Yang, W. Tian, R. Zhang, Y. Chang, J. Li, Z. Zhang*, M. Liu*. Molecular Engineering of Functional Nucleic Acids for Detection of Biological Contaminants [J]. Chinese Science Bulletin, 2026, https://www.sciengine.com/doi/10.1360/CSB-2025-6026.

23. Y. Wu; S. Liu; Q. Meng; R. Jin; Z. Zhang*; M. Liu*. Discovery of RNA-cleaving DNAzymes: Recent Advancements, New Functions and Practical Applications. Fundamental Research 2026. https://doi.org/10.1016/j.fmre.2026.03.015

22. P. Jia; Y. Chang; S. Li; W. Xue; S. Xiao; Q. Zhang; J. Li; Y. Wang; Z. Zhang*; M. Liu*. Acidic in vitro selection of metal-specific deoxyribozymes. Chemical Science 2026. 17, 5554-5562.

21. S. Xiao; Y. Chang; P. Jia; X. Li; X. Li; X. Li; H. Yuan; J. Li; Z. Zhang*; M. Liu*. Site‐Specific Recognition of Inosine‐Modified RNA by Deoxyribozyme with Distant Cleavage Site. Angewandte Chemie 2025, 137(49), e202513587.

20. R. Zhang*; C. An; J. Li; X. Li; Q. Zhang; Q. Li; S. Li; B. Wang; X. Li; Y. Chang. Z. Zhang; M. Liu*. Integrating Fluorogenic DNAzymes with Photonic Crystals for Bacterial Detection on a Microfluidic Biochip. Analytical Chemistry 2025, 97(31), 16950-16956.

19. Y. Chang*; Y. Liang; H. Song; Q. Zhang; H. Yuan; J. Li; Z. Zhang; M. Liu*. Click DNA ligation with deoxyribozyme. Nucleic Acids Research 2025, 53(18), gkaf991.

18. P. Jia; Q. Meng; Q. Zhang; R. Zhang; Z. Zhang; J. Li; X. Wang; Y. Liu; Y. Chang; M. Liu*. Engineering Acidic Deoxyribozyme with Strongly Cooperative H⁺ Binding for Subcellular Imaging. Analytical Chemistry 2025, 97(17), 9378-9385.

17. R. Amini; J. Ma; Z. Zhang; Q. Wang; J. Gu; L. Soleymani*; Y. Li*. Dimeric DNA Aptamers for the Spike Protein of SARS‐CoV‐2 Derived from a Structured Library with Dual Random Domains. Small Methods 2025, 9(6), 2401600.

16. F. Wang; Q. Meng; Z. Huang; Y. Ren; Z. Zhang; Y. Chang; R. Zhang; Y. Li; J. Li*; M. Liu*. Recent advances in aptamer-based biosensors for viral detection. Biocontaminant 2025, 1(1).

15. P. Sen; Z. Zhang; S. Sakib; J. Gu; W. Li; B. R. Adhikari; A. Motsenyat; J. L'Heureux‐Hache; J. C. Ang; G. L. Soleymani*; Y. Li*. Panesar. High‐Precision Viral Detection Using Electrochemical Kinetic Profiling of Aptamer‐Antigen Recognition in Clinical Samples and Machine Learning. Angewandte Chemie 2024, 136(20), e202400413.

14. J. Li; Z. Zhang; R. Liu; R. Amini; B. J. Salena; Y. Li*. Discovery and translation of functional nucleic acids for clinically diagnosing infectious diseases: Opportunities and challenges. TrAC Trends in Analytical Chemistry 2023, 158, 116886.

13. S. Sakib; Z. Zhang; E. Osman; F. Kanji; F. Bakhshandeh; C. Pattyn; Y. Li*; I. Zhitomirsky; L. Soleymani. Programming synthetic DNA molecules for building and breaking heterostructures between TiO₂ nanomaterials for photoelectrochemical bacterial detection. Nano Today 2023, 49, 101783.

12. Z. Zhang; J. Li; R. Amini; A. Mansfield; J. Gu; J. Xia; J. Brennan; Y. Li*. Comparative Characterization of Diverse DNA Aptamers for Recognition of Spike Proteins of Multiple SARS‐CoV‐2 Variants. Analysis & Sensing 2023, 3, e202300001.

11. P. Sen; Z. Zhang; P. Li; B. R. Adhikari; T. Guo; J. Gu; A. R. MacIntosh; C. van der Kuur; Y. Li*; L. Soleymani*. Integrating water purification with electrochemical aptamer sensing for detecting SARS-CoV-2 in wastewater. ACS Sensors 2023, 8(4), 1558-1567.

10. Z. Zhang; B. R. Adhikari; P. Sen; L. Soleymani*; Y. Li*. Functional nucleic acid-based biosensors for virus detection. Advanced Agrochem 2023, 2(3), 246-257.

9. Z. Zhang; J. Li; J. Gu; R. Amini; H. D. Stacey; J. C. Ang; D. White; C. D. M. Filipe; K. Mossman; M. S. Miller. L. Soleymani*; Y. Li*. A universal DNA aptamer that recognizes spike proteins of diverse SARS‐CoV‐2 variants of concern. Chemistry–A European Journal 2022, 28(15), e202200078.

8. A. Victorious; Z. Zhang; D. Chang; R. Maclachlan; R. Pandey; J. Xia; J. Gu; T. Hoare; L. Soleymani*; Y. Li*. A DNA Barcode‐Based Aptasensor Enables Rapid Testing of Porcine Epidemic Diarrhea Viruses in Swine Saliva Using Electrochemical Readout. Angewandte Chemie 2022, 134(31), e202204252.

7. R. Amini; Z. Zhang; J. Li; J. Gu; J. D. Brennan*; Y. Li*. Aptamers for SARS‐CoV‐2: Isolation, characterization, and diagnostic and therapeutic developments. Analysis & Sensing 2022, 2(5), e202200012.

6. J. Li; Z. Zhang; R. Amini; Y. Li*. One Solution for All: Searching for Universal Aptamers for Constantly Mutating Spike Proteins of SARS‐CoV‐2. ChemMedChem 2022, 17(13), e202200166.

5. Z. Zhang; P. Sen; B. R. Adhikari; Y. Li*; L. Soleymani*. Development of nucleic‐acid‐based electrochemical biosensors for clinical applications. Angewandte Chemie 2022, 134(50), e202212496.

4. J. Li; Z. Zhang; J. Gu; R. Amini; A. G. Mansfield; J. Xia; D. White; H. D. Stacey; J. C. Ang; G. Panesar; Y. Li*. Three on three: universal and high-affinity molecular recognition of the symmetric homotrimeric spike protein of SARS-CoV-2 with a symmetric homotrimeric aptamer. Journal of the American Chemical Society 2022, 144(51), 23465-23473.

3. J. Li; Z. Zhang; Y. Li. Functional nucleic acids for pathogen detection. Scientia Sinica Chimica 2022, 1502-1512.

2. Z. Zhang; R. Pandey; J. Li; J. Gu; D. White; H. D. Stacey; J. C. Ang; C. J. Steinberg; A. Capretta; C. D. M. Filipe. High‐affinity dimeric aptamers enable the rapid electrochemical detection of wild‐type and B.1.1.7 SARS‐CoV‐2 in unprocessed saliva. Angewandte Chemie 2021, 133(45), 24468-24476.

1. J. Li; Z. Zhang; J. Gu; H. D. Stacey; J. C. Ang; A. Capretta; C. D. M. Filipe; K. L. Mossman; C. Balion; B. J. Salena. Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library. Nucleic Acids Research 2021, 49(13), 7267-7279.