Title of Paper:Synthesis and characterization of biodegradable-cum-crosslinkable well-defined polyesters via chain-growth polycondensation in solid-liquid phase

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Date of Publication:2011-05-01

Journal:POLYMER DEGRADATION AND STABILITY

Included Journals:Scopus、SCIE、EI

Volume:96

Issue:5

Page Number:1029-1038

ISSN No.:0141-3910

Key Words:Aliphatic polyesters; Chain-growth polycondensation; Biodegradable; Thermal crosslinking

Abstract:Well-defined aliphatic polyesters, polyglycolide (PGA), polylactide (PLA) and their copolymers (PLGA) were prepared by chain-growth polycondensation of potassium 2-bromocarboxylates in solid liquid phase. The polymerization proceeded in a living fashion without any side reactions. The degrees of polymerization (D(p)) of polyesters was in agreement with the feed ratio of monomer to initiator. The polymer, which was only composed of heptamer, octamer and nonamer, possessed a narrow molecular weight distribution. Furthermore, the end groups of polymers, such as allyl and phenyl units, were directly yielded during the polymerization for the further modifying and crosslinking. The synthesized polyesters with allyl end groups were successfully crosslinked, and the products possessed biodegradability in phosphate buffer solution at 37 degrees C. (C) 2010 Elsevier Ltd. All rights reserved.