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个人信息Personal Information
副教授
博士生导师
硕士生导师
性别：女
毕业院校：美国伊利诺伊大学香槟
学位：博士
所在单位：化工学院
学科：高分子材料. 高分子化学与物理
办公地点：西部校区化工实验楼A207
联系方式：nzheng@dlut.edu.cn
电子邮箱：nzheng@dlut.edu.cn
Iridium-Catalyzed Highly Regioselective Azide-Ynamide Cycloaddition to Access 5-Amido Fully Substituted 1,2,3-Triazoles under Mild, Air, Aqueous, and Bioorthogonal Conditions
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论文类型：期刊论文
发表时间：2017-11-17
发表刊物：ORGANIC LETTERS
收录刊物：SCIE、PubMed
卷号：19
期号：22
页面范围：6200-6203
ISSN号：1523-7060
摘要：A highly regioselective method to access 5-amido fully Substituted 1,2,3-triazoles by iridium-catalyzed-azide-ynamide cycloaddition under mild, air, aqueous, and bioorthogonal conditions is reported. The excellent regioselectivities may derive from, the strong coordination between the carbonyl Oxygen of ynamide and the pi-acidic iridium. Since the iridium ion is insensitive to oxygen/water and exhibits low cytotoxicity, it could catalyze this reaction in both organic and biological environments efficiently. Preparation in gram-scale and application in carbohydrates highlight this method.