祖国，外科学博士，副主任医师，大连理工大学医学部硕士研究生导师，辽宁省“百千万人才工程”千层次人选；“大连市青年五四奖章”获得者；大连市高层次人才青年才俊。

主要从事重症患者肠缺血再灌注损伤保护和损伤后的修复再生的基础及临床转化研究，以及胃肠道肿瘤的早期诊断和外科治疗。主持国家自然科学基金1项，辽宁省博士启动基金1项，大连市高层次人才课题1项，参与国家自然科学基金2项。目前以第一作者及通讯作者发表SCI论文20余篇。目前是International Journal of Gastroenterology、Acta Materia Medica、Traditional Medicine Research青年编委等。

主持和参与的科研项目：

1、miR-142-3p靶向调控FoxM1/ Nurr1通路在肠缺血再灌注损伤后再生中的作用及机制研究（项目编号：81700465，国家自然科学基金青年基金项目，20万，主持）。

2、Nurr1/p21通路在肠缺血再灌注损伤修复中的作用机制及miR-381-3p的调控（项目编号：81671954，国家自然科学基金面上项目，57万，参与）。

3、Sirt1 调控peroxiredoxin6在肠缺血再灌注所致肠黏膜屏障损伤中的保护作用及机制研究（项目编号：81501699，国家自然科学基金青年基金项目，18万，参与)。

4、骨髓间充质干细胞通过Foxm1/Nurr1通路促进小肠缺血再灌注损伤后的再生（项目编号：2019-BS-059，辽宁省自然科学基金博士启动基金，3万，主持)。

5、表没食子儿茶素没食子酸酯通过Nurr1/p21通路促进肠缺血再灌注损伤后的再生（项目编号：2018RQ27，大连市高层次人才计划青年之星项目，10万，主持）。

论文成果：

1. Zirui Jia, Yuhang Wang, Jiacheng Gao, Mingcan Zheng, Puxu Wang, Guo Zu. miR-379-5p inhibition enhances intestinal epithelial proliferation and barrier function recovery after ischemia/reperfusion by targeting EIF4G2. Shock. 2023.(in press)

2.Gao J, Wang Y, Jia Z, Xue J, Zhou T, Zu G. (-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1. Pharm Biol. 2023;61(1):1310-1317.

3. Jia Z, Gao J, Wang Y, Zhou T, Zhang X, Zu G. Clinicopathological and prognostic value of lysyl oxidase expression in gastric cancer: a systematic review, meta-analysis and bioinformatic analysis. Sci Rep. 2022;12(1):16786.

4. Wang Y, Jia Z, Gao J, Zhou T, Zhang X and Zu G. Clinicopathological and Prognostic Value of USP22 Expression in Gastric Cancer: A Systematic Review and Meta-Analysis and Database Validation. Front. Surg. 2022; 9:920595.

5.Jia Z, Wang Y, Gao J, Zu G. Lack of relationship between PROX1 expression and clinicopathological parameters and prognosis in gastric cancer patients: a meta-analysis and TCGA analysis. BMC Gastroenterol. 2022 Mar 27;22(1):142.

6.Guo Zu, Jiacheng Gao, Tingting Zhou. The clinicopathological and prognostic significance of SOX9 expression in gastric carcer: meta-analysis and TCGA analysis. Front. Oncol. 2021;11:668946.

7.Zhang X, Xue J, Yang H, Zhou T, Zu G. TNFAIP6 promotes invasion and metastasis of gastric cancer and indicates poor prognosis of patients. Tissue Cell. 2021;68:101455.

8.Cao X, Xue J, Yang H, Han X, Zu G. Association of Clinical Parameters and Prognosis with the Pretreatment Systemic Immune-inflammation Index (SII) in Patients with Gastric Cancer. J Coll Physicians Surg Pak. 2021 Jan;31(1):83-88.

9.Xue J, Yang H, Huang S, Zhou T, Zhang X, Zu G. Comparison of the overall survival of proximal and distal gastric cancer after gastrectomy: a systematic review and meta-analysis. World J Surg Oncol. 2021 Jan 19;19(1):17.

10.Guo Zu, Jing Guo, Tingting Zhou, Ningwei Che, Xiangwen Zhang. The transcription factor FoxM1 activates Nurr1 to promote intestinal regeneration after ischemia/reperfusion injury. Experimental & Molecular Medicine. 2019 Nov 8;51(11): 1-12.

11.Zu G, Jiang K, Zhou T, Che N, Zhang X. Two-dimensional versus three- dimensional laparoscopic gastrectomy in surgical efficacy for gastric cancer: a systematic review and meta-analysis. Clin Transl Oncol. 2020 Jan;22(1):122-129.

12.Zu G, Zhou T, Che N, Zhang X. Salvianolic Acid A Protects Against Oxidative Stress and Apoptosis Induced by Intestinal Ischemia-Reperfusion Injury Through Activation of Nrf2/HO-1 Pathways. Cell Physiol Biochem. 2018;49(6):2320-2332.

13.Zhang X, Zhou T, Li W, Zhang T, Che N, Zu G. Clinicopathological and prognostic significance of C/EBP homologous protein (CHOP) in advanced gastric cancer. Pathol Res Pract. 2018 Aug;214(8):1105-1109.

14.Liu B, Han Y, Jiang L, Jiang D, Li W, Zhang T, Zu G, Zhang X. Clinicopathological and prognostic significance of the RUNX3 expression in gastric cancer: a systematic review and meta-analysis. Int J Surg. 2018 Mar 22;53:122-128.

15.Jiang D, Jiang L, Liu B, Huang H, Li W, Zhang T, Zu G, Zhang X. Clinicopathological and prognostic significance of FoxM1 in gastric cancer: A meta-analysis. Int J Surg. 2017 Dec;48:38-44.

16.Jiang L, Yang L, Huang H, Liu BY, Zu G. Prognostic and clinical significance of claudin-1 in colorectal cancer: A systemic review and meta-analysis. Int J Surg. 2017 Mar;39:214-220.

17.Zu G, Zhang T, Li W, Sun Y, Zhang X. Impact of clinicopathological parameters on survival after multiorgan resection among patients with T4 gastric carcinoma: a systematic review and meta-analysis. Clin Transl Oncol. 2017 Jun;19(6):750-760.

18.Zu G, Guo J, Che N, Zhou T, Zhang X. Protective effects of ginsenoside Rg1 on intestinal ischemia/reperfusion injury-induced oxidative stress and apoptosis via activation of the Wnt/β-catenin pathway. Sci Rep. 2016 Dec 2;6:38480.

19.Zu G, Yao J, Ji A, Ning S, Luo F, Li Z, Feng D, Rui Y, Li Y, Wang G, Tian X. Nurr1 promotes intestinal regeneration after ischemia/reperfusion injury by inhibiting the expression of p21 (Waf1/Cip1). J Mol Med (Berl). 2017 Jan;95(1):83-95.

20.Zu G, Ji A, Zhou T, Che N. Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta-analysis. Int J Surg. 2016 Feb;26:32-7.