点击次数：

论文类型：期刊论文

发表时间：2019-05-22

发表刊物：ACS APPLIED MATERIALS & INTERFACES

收录刊物：PubMed、SCIE、EI

卷号：11

期号：20

页面范围：18224-18232

ISSN号：1944-8244

关键字：photodynamic therapy; pi-pi interactions; ROS degradable poly(TPP); quantitative TPP loading; improved singlet oxygen quantum yield

摘要：The natural planar and rigid structures of most of the hydrophobic photosensitizers (PSs) [such as tetraphenyl porphyrin (TPP)] significantly reduce their loading efficiencies in polymeric nanoparticles (NPs) because of the strong pi-pi interaction-induced aggregation. This aggregation-caused quenching will further reduce the quantum yield of singlet oxygen (O-1(2)) generation and weaken the efficiency of photodynamic therapy (PDT). In addition, the small molecular PSs exhibit short tumor retention time and tend to be easily cleared once released. Herein, poly(TPP) NPs, prepared by cross-linking of reactive oxygen species degradable, thioketal linkers and TPP derivatives, followed by coprecipitation, were first developed with quantitative loading efficiency (>99%), uniform NP sizes (without aggregation), increased singlet oxygen quantum yield (Phi(Delta) = 0.79 in dimethyl sulfoxide compared with 0.52 for original TPP), increased in vitro phototoxicity, extended tumor retention time, light-triggered on-demand release, and enhanced in vivo antitumor efficacy, which comprehensively address the multiple issues for most of the PSs in the PDT area.