Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2016-12-01

Journal: PHYTOCHEMISTRY LETTERS

Included Journals: Scopus、SCIE

Volume: 18

Page Number: 157-161

ISSN: 1874-3900

Key Words: Talaromyces wortmannii; Polyketides; OSMAC; Absolute configuration; Anthelmintic activity; NADH-fumarate reductase inhibitor

Abstract: Three new polyketides, wortmannilactones I1-I3, were purified from Talaromyces wortmannii using the One Strain Many Compounds (OSMAC) strategy. The polyketides' structures were established using IR, 1D and 2D NMR, and HRESIMS analyses and the absolute configurations were identified by comparison of experimental and calculated ECDs. These polyketides exhibit selective inhibitory activity against NADH-fumarate reductase. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.