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Date of Publication:2009-01-01

Journal:过程工程学报

Issue:1

Page Number:95-100

ISSN No.:1009-606X

Abstract:The fed-batch fermentation of 2,3-butanediol by Klebsiella pneumoniae from Dioscorea zingiberensis was investigated. The concentration and productivity of target products, organic acid metabolism and glucose metabolic flux distributions during the fermentation were analyzed. The results showed that organic acids in Dioscorea zingiberensis could promote metabolic flux in tricarboxylic acids cycle and acetic acid production pathway and decrease the butane diacid production pathway, thus, 2,3-butanediol production was increased. 80.20 g/L of 2,3-butanediol, 86.19 g/L of 2,3-butanediol and acetoin, corresponding to 1.54 g/(L��h) of productivity, were obtained using the hydrolyzate of Dioscorea zingiberensis as substrate and feeding glucose during fed-batch fermentation, which increased 8.50%, 7.38% and 7.69%, respectively, compared with that using glucose as sole substrate.

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